The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Mild obesity-related diabetes (MOD) – mechanisms and pathways

Leaders for work package 6: Nils Wierup, Cecilia Holm, and Olga Göransson

The mild obesity-related diabetes (MOD) cluster includes the most obese but not the most insulin resistant individuals. Obesity is a common risk factor for type 2 diabetes and its complications. This work package explores the differences between metabolically healthy and unhealthy obesity and focuses on elucidating the mechanisms underlying type 2 diabetes improvement or remission after gastric bypass surgery. The role of Salt‐inducible kinases (SIK) and genetic variations of SIK isoforms as potential drivers of obesity and insulin resistance are also explored.


  • To identify targetable mechanisms and pathways underlying initiation and progression of MOD.

Selected publications


Nils Wierup
Work Package Leader
Professor of neuroendocrine cell biology
+46 (0)703 78 66 24
nils [dot] wierup [at] med [dot] lu [dot] se

Cecilia Holm
Work Package Leader
Professor of molecular cell biology
+46 (0)70 637 04 85
+ 46 (0)46 222 85 81
cecilia [dot] holm [at] med [dot] lu [dot] se

Olga Göransson
Work Package Leader
Professor of molecular nutrition
+46 (0)702 78 69 19
+46 (0)46 222 95 52
olga [dot] goransson [at] med [dot] lu [dot] se