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Mild age-related diabetes (MARD) – mechanisms and pathways

Leaders of work package 7: Jan Nilsson and Olle Melander

This work package focuses on diabetes-driven cardiovascular disease (CVD). The mild age-related diabetes (MARD) cluster, together with the mild obesity-related diabetes (MOD) and the severe insulin-resistant diabetes (SIRD) has the highest risk of developing CVD.

Central to the studies in this work package are a number of well-characterised cohorts, extensively phenotyped for CVD relevant parameters and with long follow-up, including the Malmö Diet Cancer study (MDC), the Malmö Offspring Study (MOS), the Carotid Plaque Imaging Project (CPIP), the SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT-CVD), the Malmö part of the Swedish CardioPulmunary BioImage Study (SCAPIS), and the Malmö AMI in the elderly (MAMI-Y) studies. 

Among other activities, we focus on the role of immune responses against modified self-antigens and on developing therapies targeting these immune processes. We also work on developing imaging techniques and identifying biomarkers that can identify subjects with high-risk for CVD and vascular injury.


  • To identify targetable mechanisms and pathways underlying initiation and progression of MARD and CVD.

Selected publications




Jan Nilsson
Work Package Leader
Professor Emeritus of experimental cardiovascular research
+46 (0)73 339 12 30
+46 (0)40 39 12 30
jan [dot] nilsson [at] med [dot] lu [dot] se

Olle Melander
Work Package Leader
Professor of internal medicine 
+46 (0)704 54 68 20
+46 (0)40 39 12 09
olle [dot] melander [at] med [dot] lu [dot] se