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Molecular endocrinology

Cecilia Holm’s group

Our research

The overall purpose of our research is to develop novel strategies for the prevention and treatment of diabetes and related metabolic disorders.

Our group works mainly in two different areas. The first area involves the identification and evaluation of a new generation of probiotic bacterial strains that can be used to promote metabolic health. Bacterial strains with potentially beneficial properties are screened in different cell lines and primary cells, after which the most promising strains are evaluated further in animal models and eventually in clinical trials. This project is performed in collaboration with Probi AB.

The second area involves the elucidation of mechanisms underlying the development of brain insulin resistance and cognitive dysfunction, with special focus on the enzyme hormone-sensitive lipase. Mouse models with genetic or pharmacological inhibition of hormone-sensitive lipase are studied using a battery of metabolic and behavioral tests. Experiments are also performed in isolated primary cells, for example neurons and adipocytes. This project is performed in collaboration with João Duarte's group Diabetes and brain function at Lund University Diabetes Centre.

Link to a web page with more information about João Duarte's group Diabetes and brain function

Aims

  • To identify novel probiotic strains with the ability to promote metabolic health. 
  • To elucidate the role of brain hormone-sensitive lipase in the development of metabolic and neurodegenerative disorders.

Impact

Our research will contribute to the development of a new generation of probiotic strains that can be used to preserve metabolic health. Furthermore, understanding the role of hormone-sensitive lipase in the brain could form the basis for novel concepts for pharmacological treatment of diabetes and neurodegenerative diseases. 

Research output

Link to a list of research output by the group in Lund University’s research portal

Team members

Link to a list of team members in Lund University's research portal
 

Current major grants

  • Strategic mobility grant from the Swedish Foundation for Strategic Research 2021-2022
  • Direktör Albert Påhlsson’s Foundation 2022
Photo of Cecilia Holm.

Cecilia Holm

Cecilia Holm
Prinicipal investigator
Professor of molecular cell biology
+46 70 637 04 85
+46 46 222 85 81
cecilia [dot] holm [at] med [dot] lu [dot] se

Cecilia Holm’s profile in Lund University’s research portal

Affiliations

EXODIAB: Excellence of Diabetes Research in Sweden 

Link to EXODIAB’s page in Lund University’s research portal