Cecilia Holm’s group
The overall purpose of our research is to develop novel strategies for the prevention and treatment of diabetes and related metabolic disorders.
Our group works mainly in two different areas. The first area involves the identification and evaluation of a new generation of probiotic bacterial strains that can be used to promote metabolic health. Bacterial strains with potentially beneficial properties are screened in different cell lines and primary cells, after which the most promising strains are evaluated further in animal models and eventually in clinical trials. This project is performed in collaboration with Probi AB.
The second area involves the elucidation of mechanisms underlying the development of brain insulin resistance and cognitive dysfunction, with special focus on the enzyme hormone-sensitive lipase. Mouse models with genetic or pharmacological inhibition of hormone-sensitive lipase are studied using a battery of metabolic and behavioral tests. Experiments are also performed in isolated primary cells, for example neurons and adipocytes. This project is performed in collaboration with João Duarte's group Diabetes and brain function at Lund University Diabetes Centre.
- To identify novel probiotic strains with the ability to promote metabolic health.
- To elucidate the role of brain hormone-sensitive lipase in the development of metabolic and neurodegenerative disorders.
Our research will contribute to the development of a new generation of probiotic strains that can be used to preserve metabolic health. Furthermore, understanding the role of hormone-sensitive lipase in the brain could form the basis for novel concepts for pharmacological treatment of diabetes and neurodegenerative diseases.
Current major grants
- Direktör Albert Påhlsson’s Foundation 2023-2024
Professor of molecular cell biology
+46 (0)70 637 04 85
+46 (0)46 222 85 81
cecilia [dot] holm [at] med [dot] lu [dot] se