Severe insulin-resistant diabetes (SIRD) – mechanisms and pathways
Leaders of work package 5: Ola Hansson and Eva Degerman
SIRD is a novel form of diabetes representing the most insulin resistant (both hepatic and peripheral) form, with most features of the metabolic syndrome but also hepatic steatosis.
In this work-package we explore mechanisms and pathways relevant to insulin resistance in various organs and tissues, such as liver, adipose tissue, kidney, skeletal muscle, heart, brain, inner ear.
Objectives
- To identify targetable mechanisms and pathways underlying initiation and progression of SIRD.
- To identify common pathways of insulin resistance in various target organs.
Selected publications
- Title: Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance
Reference: Biochemical Society Transaction, 51 (1), 287-301 (2023) - Title: Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice
Reference: Nutritional Neuroscience, 26 (11), 1090-1102 (2023) - Title: Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes
Reference: Acta Oto-Laryngologica, 143 (2), 127-133 (2023) - Title: Expansion of the Inguinal Adipose Tissue Depot Correlates With Systemic Insulin Resistance in C57BL/6J Mice
Reference: Frontiers in Cell and Developmental Biology, 10, 942374 (2022) - Title: High-throughput muscle fiber typing from RNA sequencing data
Reference: Skeletal Muscle, 12:16 (2022)
Contact
Ola Hansson
Work Package Leader
Associate Professor of functional genomics
+46 (0)725 21 46 43
+46 (0)40 39 12 28
ola [dot] hansson [at] med [dot] lu [dot] se
Eva Degerman
Work Package Leader
Professor of experimental diabetes research
+46 (0)70 885 83 62
+46 (0)46 222 85 83
eva [dot] degerman [at] med [dot] lu [dot] se