Severe insulin-resistant diabetes (SIRD) – mechanisms and pathways

SIRD is a novel form of diabetes representing the most insulin resistant (both hepatic and peripheral) form, with most features of the metabolic syndrome but also hepatic steatosis. 

In this work-package we explore mechanisms and pathways relevant to insulin resistance in various organs and tissues, such as liver, adipose tissue, kidney, skeletal muscle, heart, brain, inner ear. 

Objectives

• To identify targetable mechanisms and pathways underlying initiation and progression of SIRD.
• To identify common pathways of insulin resistance in various target organs.

Selected publications

• Title: Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance
  Reference: Biochemical Society Transaction, 51 (1), 287-301 (2023)
• Title: Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice
  Reference: Nutritional Neuroscience, 26 (11), 1090-1102 (2023)
• Title: Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes
  Reference: Acta Oto-Laryngologica, 143 (2), 127-133 (2023)
• Title: Expansion of the Inguinal Adipose Tissue Depot Correlates With Systemic Insulin Resistance in C57BL/6J Mice
  Reference: Frontiers in Cell and Developmental Biology, 10, 942374 (2022)
• Title: High-throughput muscle fiber typing from RNA sequencing data
  Reference: Skeletal Muscle, 12:16 (2022)