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Severe insulin-resistant diabetes (SIRD) – mechanisms and pathways

Leaders of work package 5: Ola Hansson and Eva Degerman

SIRD is a novel form of diabetes representing the most insulin resistant (both hepatic and peripheral) form, with most features of the metabolic syndrome but also hepatic steatosis. 

In this work-package we explore mechanisms and pathways relevant to insulin resistance in various organs and tissues, such as liver, adipose tissue, kidney, skeletal muscle, heart, brain, inner ear. 

Objectives

  • To identify targetable mechanisms and pathways underlying initiation and progression of SIRD.
  • To identify common pathways of insulin resistance in various target organs.

Selected publications

 

 

Contact

Ola Hansson
Work Package Leader
Associate Professor of functional genomics
+46 (0)725 21 46 43
+46 (0)40 39 12 28
ola [dot] hansson [at] med [dot] lu [dot] se

Eva Degerman
Work Package Leader
Professor of experimental diabetes research
+46 (0)70 885 83 62
+46 (0)46 222 85 83
eva [dot] degerman [at] med [dot] lu [dot] se