The Celiac disease Prediction in Skåne is a spin-off investigation for celiac disease using the DiPiS cohort. It tested to what extent the tissue transglutaminase autoantibodies (tTG IgG or IgA) predict celiac disease (CD). It also tested whether environmental factors other than gluten may initiate the disease process. The genetic factor with the highest risk for celiac disease is HLA-DQ 2/2 homozygocity. As HLA was used as the primary risk factor in DiPiS (HLA-DQ 2, 8, or both), children with the DQ2/2 gentotype were also included in the DiPis cohort to be studied in CiPiS.
It is reported from the CiPiS investigation of children at three years of age that only children with DQ2, 8, or both had developed tTG IgG or IgA. None of more than 3000 children without DQ 2, 8, or both had these autoantibodies while 3% of children with these HLA types were tTG autoantibody positive. These children were found to have a very high risk for celiac disease.
CiPiS is supported by grants from the Skåne County Council for Research & Development , Öresund Diabetes Academy