Manca Mohar, Masters Student
Master´s Thesis project: Role of apolipoprotein A-I an the regulation if insulin secretion from pancreatic beta cells.
The aim of this thesis is to explain the biological mechanism by which ApoA-I improves insulin secretion and islet function in an INS1E cell culture model. The project focuses on the determination of ApoA-I action in different steps of glucose stimulated insulin secretion (GSIS) signal transduction pathway. The following will be explored:
1. Assess if ApoA-I affects the ATP/ADP ratio which is necessary for GSIS.
2. Determine the effect of ApoA-I on mitochondrial metabolism.
3. Further explore the insulin exocytosis process in response to ApoA-I.