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A growing number of publications are based on results from the Human Tissue Laboratory.

Lundquist I, Mohammed Al-Amily I, Meidute Abaraviciene S, Salehi A. Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System. PLoS One. 2016 Nov 7;11(11)   



Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. Diabetologia. 2016 Oct 29.

PMID:    27796421


Radenkovic M, Uvebrant K, Skog O, Sarmiento L, Avartsson J, Storm P, Vikman P, Bertilsson PA, Fex M, Korsgren O, Cilio CM. Characterization of resident lymphocytes in human pancreatic islets. Clin Exp Immunol. 2016 Oct 26.

PMID: 27783386


Dunér P, Al-Amily IM, Soni A, Asplund O, Safi F, Storm P, Groop L, Amisten S, Salehi A. Adhesion G-protein coupled receptor G1 (ADGRG1/GPR56) and pancreatic β-cell function. J Clin Endocrinol Metab. 2016 Sep 16

PMID: 27636017


Nagaraj V, Kazim AS, Helgeson J, Lewold C, Barik S, Buda P, Reinbothe TM, Wennmalm S, Zhang E, Renström E. Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol. Mol Endocrinol. 2016 Oct;30(10):1059-1069.

PMID: 27533789


Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N. Diabetologia. 2016 Sep;59(9):1928-37.

PMID: 27338624


Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 May 19;12(5)

PMID: 27195491


Tuomi T, Nagorny CL, Singh P, Bennet H, Yu Q, Alenkvist I, Isomaa B, Östman B, Söderström J, Pesonen AK, Martikainen S, Räikkönen K, Forsén T, Hakaste L, Almgren P, Storm P, Asplund O, Shcherbina L, Fex M, Fadista J, Tengholm A, Wierup N, Groop L, Mulder H. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. Cell Metab. 2016 Jun 14;23(6):1067-77.

PMID: 27185156


Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk. Epigenetics. 2016 Jul 2;11(7):482-8.

PMID: 27148772


Bacos K, Gillberg L2, Volkov P, Olsson AH, Hansen T, Pedersen O, Gjesing A4, Eiberg H, Tuomi T, Almgren P, Groop L, Eliasson L, Vaag A, Dayeh T, Ling C. Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. Nat Commun. 2016 Mar 31;7:11089.

PMID: 27029739


Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet. 2016 May;48(5):519-27

PMID:  26998692


Ganic E, Singh T, Luan C, Fadista J, Johansson JK, Cyphert HA, Bennet H, Storm P, Prost G, Ahlenius H, Renström E, Stein R, Groop L, Fex M, Artner I. MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.

PMID: 26904947


Zhou Y, Oskolkov N, Shcherbina L, Ratti J, Kock KH, Su J, Martin B, Oskolkova MZ, Göransson O, Bacon J, Li W, Bucciarelli S, Cilio C, Brazma A, Thatcher B, Rung J, Wierup N, Renström E, Groop L, Hansson O. HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets. Mol Cell Endocrinol. 2016 Jul 15;430:138-45

PMID: 26845344


Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH. Thrombin stimulates insulin secretion via protease-activated receptor-3Islets. 2015;7(4):e1118195

PMID: 26742564


Ottosson-Laakso E, Tuomi T, Forsén B, Gullström M, Groop PH, Groop L, Vikman P. Influence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time. PLoS One. 2016 Jan 6;11(1):e0146114

PMID: 26735923


Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans. Diabetologia. 2016 Apr;59(4):744-54

PMID: 26733006


Berclaz C, Schmidt-Christensen A, Szlag D, Extermann J, Hansen L, Bouwens A, Villiger M, Goulley J, Schuit F, Grapin-Botton A, Lasser T, Holmberg D. Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging. Diabetologia. 2016 Mar;59(3):550-9.

PMID: 26613896


Ganic E, Johansson JK, Bennet H, Fex M, Artner I. Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes. Biochem Biophys Res Commun. 2015 Dec 25;468(4):629-35.

PMID: 26546820


Bennet H, Balhuizen A, Medina A, Dekker Nitert M, Ottosson Laakso E, Essén S, Spégel P, Storm P, Krus U, Wierup N, Fex M. Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes. Peptides. 2015 Sep;71:113-20

PMID: 26206285


Nagaraj V, King B, Storm P, Vikman P, Ottosson-Laakso E, Blom AM, Renström E. Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion. Biochem Biophys Res Commun. 2015 May 8;460(3):518-24.

PMID: 25797618


Taneera J, Fadista J, Ahlqvist E, Atac D, Ottosson-Laakso E, Wollheim CB, Groop L.

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia. Hum Mol Genet. 2015 Apr 1;24(7):1945-55.

PMID: 25489054


Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O. TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet. 2014 Dec 15;23(24):6419-31

PMID: 25015099

Hall E, Volkov P, Dayeh T, Esguerra JL, Salö S, Eliasson L, Rönn T, Bacos K, Ling C. Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets. Genome Biol. 2014 Dec 3;15(12):522.



Olsson AH, Volkov P, Bacos K, Dayeh T, Hall E, Nilsson EA, Ladenvall C, Rönn T, Ling C. Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet. 2014 Nov 6;10(11)

PMID: 25375650


Taneera J, Storm P, Groop L. Downregulation of type II diabetes mellitus and maturity onset diabetes of young pathways in human pancreatic islets from hyperglycemic donors. J Diabetes Res. 2014;2014:237535. 2014 Oct

PMID: 25379510


Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9

PMID: 25201977


Hall E, Volkov P, Dayeh T, Bacos K, Rönn T, Nitert MD, Ling C1. Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets. BMC Med. 2014 Jun 23;12:103.

PMID: 24953961


Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, Spégel P, Metodiev MD, Larsson NG, Eliasson L, Wierup N, Mulder H. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet. 2014 Jun 10.

      PMID:  24916378



Edlund A, Esguerra JL, Wendt A, Flodström-Tullberg M, Eliasson L. CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med. 2014 May 28;12(1):87

PMID: 24885604


Krus U, King BC, Nagaraj V, Gandasi NR, Sjölander J, Buda P, Garcia-Vaz E, Gomez MF, Ottosson-Laakso E, Storm P, Fex M, Vikman P, Zhang E, Barg S, Blom AM, Renström E. The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events. Cell Metab. 2014 May 6;19(5):883-90.

PMID: 24726385


Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V. A central role for GRB10 in regulation of islet function in man. PLoS Genet. 2014 Apr 3;10(4)

PMID: 24699409


Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C. Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet. 2014 Mar 6;10(3):e1004160.

PMID: 24603685


Sarmiento L, Frisk G, Anagandula M, Cabrera-Rode E, Roivainen M, Cilio CM.

Expression of innate immunity genes and damage of primary human pancreatic islets by epidemic strains of Echovirus: implication for post-virus islet autoimmunity. PLoS One. 2013 Nov 1;8(11):e77850

PMID: 24223733


Kanatsuna N, Taneera J, Vaziri-Sani F, Wierup N, Larsson HE, Delli A, Skärstrand H, Balhuizen A, Bennet H, Steiner DF, Törn C, Fex M, Lernmark Å Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. J Biol Chem. 2013 Oct 4;288(40):29013-23

PMID: 23935095


Taneera J, Fadista J, Ahlqvist E, Zhang M, Wierup N, Renström E, Groop L. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

Mol Cell Endocrinol. 2013 Aug 15;375(1-2):35-42

PMID:  23707792


Jonsson A, Ladenvall C, Ahluwalia TS, Kravic J, Krus U, Taneera J, Isomaa B, Tuomi T, Renström E, Groop L, Lyssenko V. Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans.

Diabetes. 2013 Aug;62(8):2978-83.

PMID: 23557703


Hall E, Dayeh T, Kirkpatrick CL, Wollheim CB, Dekker Nitert M, Ling C. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. BMC Med Genet. 2013 Jul 23;14:76.

PMID:  23879380


Dayeh TA, Olsson AH, Volkov P, Almgren P, Rönn T, Ling C. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. Diabetologia. 2013 May;56(5):1036-46.

PMID: 23462794


Reinbothe TM, Alkayyali S, Ahlqvist E, Tuomi T, Isomaa B, Lyssenko V, Renström E. The human L-type calcium channel Ca(v)1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.

Diabetologia. 2013 Feb;56(2):340-9. doi: 10.1007/s00125-012-2758-z. Epub 2012 Nov 15.

PMID:  23229155


Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH. Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009.

PMID: 23140642


Travers ME, Mackay DJ, Dekker Nitert M, Morris AP, Lindgren CM, Berry A, Johnson PR, Hanley N, Groop LC, McCarthy MI, Gloyn AL. Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets. Diabetes. 2013 Mar;62(3):987-92. doi: 10.2337/db12-0819. Epub 2012 Nov 8.

      PMID:  23139357


Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V. Effect of a common variant of the PCSK2 gene on reduced insulin secretion. Diabetologia. 2012 Dec;55(12):3245-51. doi: 10.1007/s00125-012-2728-5. Epub 2012 Sep 26.

      PMID:  23011353


Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, Eliasson L. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

Mol Cell Endocrinol. 2012 Nov 25;364(1-2):36-45. doi: 10.1016/j.mce.2012.08.009. Epub 2012 Aug 23.

PMID: 22939844


Asad S, Nikamo P, Gyllenberg A, Bennet H, Hansson O, Wierup N; Diabetes Incidence in Sweden Study Group, Carlsson A, Forsander G, Ivarsson SA, Larsson H, Lernmark Å, Lindblad B, Ludvigsson J, Marcus C, Rønningen KS, Nerup J, Pociot F, Luthman H, Fex M, Kockum I. HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13.

PLoS One. 2012;7(5):e35439. doi: 10.1371/journal.pone.0035439. Epub 2012 May 1.

PMID: 22563461


Yang BT, Dayeh TA, Volkov PA, Kirkpatrick CL, Malmgren S, Jing X, Renström E, Wollheim CB, Nitert MD, Ling C. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol. 2012 Jul;26(7):1203-12. doi: 10.1210/me.2012-1004. Epub 2012 May 8.

PMID: 22570331


Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, Ahlqvist E, Jonsson A, Lyssenko V, Vikman P, Hansson O, Parikh H, Korsgren O, Soni A, Krus U, Zhang E, Jing XJ, Esguerra JL, Wollheim CB, Salehi A, Rosengren A, Renström E, Groop L. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.  Cell Metab. 2012 Jul 3;16(1):122-34. doi: 10.1016/j.cmet.2012.06.006.

     PMID: 22768844



Taneera J, Jin Z, Jin Y, Muhammed SJ, Zhang E, Lang S, Salehi A, Korsgren O, Renström E, Groop L, Birnir B. γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.

 Diabetologia. 2012 Jul;55(7):1985-94. doi: 10.1007/s00125-012-2548-7. Epub 2012 Apr 27.

      PMID: 22538358


Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, Walker JN, Barrett A, Johnson PR, Lyssenko V, McCarthy MI, Groop L, Salehi A, Gloyn AL, Renström E, Rorsman P, Eliasson L. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

Diabetes. 2012 Jul;61(7):1726-33. doi: 10.2337/db11-1516. Epub 2012 Apr 9.

PMID: 22492527


Stamenkovic JA, Olsson AH, Nagorny CL, Malmgren S, Dekker-Nitert M, Ling C, Mulder H. Regulation of core clock genes in human islets.

Metabolism. 2012 Feb 1. [Epub ahead of print]

PMID: 22304835


Riva M, Nitert MD, Voss U, Sathanoori R, Lindqvist A, Ling C, Wierup N. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.

Cell Tissue Res. 2011 Dec;346(3):393-405. Epub 2011 Nov 23.

PMID: 22108805


Olsson AH, Yang BT, Hall E, Taneera J, Salehi A, Dekker Nitert M, Ling C. Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes.

Eur J Endocrinol. 2011 Oct;165(4):589-95. Epub 2011 Jul 20.



Ahlqvist E, Turrini F, Lang ST, Taneera J, Zhou Y, Almgren P, Hansson O, Isomaa B, Tuomi T, Eriksson K, Eriksson JG, Lyssenko V, Groop L. A common variant upstream of the PAX6 gene influences islet function in man.

Diabetologia. 2011 Sep 16. [Epub ahead of print]



Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad S, Poulsen P, Vaag A, Laakso M, Gomez MF, Groop L. Pleiotropic effects of GIP on islet function involve osteopontin.

Diabetes. 2011 Sep;60(9):2424-33. Epub 2011 Aug 1.



Spégel P, Malmgren S, Sharoyko VV, Newsholme P, Koeck T, Mulder H. Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.Biochem J. 2011 Apr 1;435(1):277-84.



Bolmeson C, Esguerra JL, Salehi A, Speidel D, Eliasson L, Cilio CM. Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.

 Biochem Biophys Res Commun. 2011 Jan 7;404(1):16-22. Epub 2010 Nov 19.



Koeck T, Olsson AH, Nitert MD, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG, Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H, Ling C. A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetesCell Metab. 2011 Jan 5;13(1):80-91



Yang BT, Dayeh TA, Kirkpatrick CL, Taneera J, Kumar R, Groop L, Wollheim CB, Nitert MD, Ling C. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.Diabetologia. 2011 Feb;54(2):360-7. Epub 2010 Nov 23.

PMID: 21104225


Heimann E, Jones HA, Resjö S, Manganiello VC, Stenson L, Degerman E. Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.

PLoS One. 2010 Dec 1;5(12):e14191

PMID: 21152070


Yang BT, Dayeh TA, Kirkpatrick CL, Taneera J, Kumar R, Groop L, Wollheim CB, Nitert MD, Ling C. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.

Diabetologia. 2010 Nov 23.

PMID: 21104225


Bolmeson C, Esguerra JL, Salehi A, Speidel D, Eliasson L, Cilio CM. Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects.

Biochem Biophys Res Commun. 2010 Nov 19.

PMID: 21094635


Ringström C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF, Friis-Hansen L, Wierup N. Apelin is a novel islet peptide.

Regul Pept. 2010 Jun 8;162(1-3):44-51.

PMID: 20346374


De Marinis YZ, Zhang E, Amisten S, Taneera J, Renström E, Rorsman P, Eliasson L. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

Diabetologia. 2010 Apr;53(4):717-2

PMID: 20020096


Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, Renström E. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.

Science. 2010 Jan 8;327(5962):217-20.

PMID: 19965390


Malmgren S, Nicholls DG, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H, Sharoyko VV. Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

J Biol Chem. 2009 Nov 20;284(47):32395-404.

PMID: 19797055


Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL. Tissue-specific alternative splicing of TCF7L2.

Hum Mol Genet. 2009 Oct 15;18(20):3795-804.

PMID: 19602480


Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, Nilsson P, Groop L, Lyssenko V. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.

Diabetes. 2009 Oct;58(10):2409-13.

PMID: 19584308  


Osmark P, Hansson O, Jonsson A, Rönn T, Groop L, Renström E. Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

Diabetologia. 2009 May;52(5):850-4.

PMID: 19247628


Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Nat Genet. 2009 Jan;41(1):82-8. Epub 2008 Dec 7.

PMID: 19060908