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Kate Louise Möller Herum

Current position

Guest researcher, Biotech Research & Innovation Centre (BRIC), University of Copenhagen
Kate [dot] Herum [at] bric [dot] ku [dot] dk

Thesis title

Syndecan-4 in cardia fibroblasts - Role in regulation of extracellular matrix and myocardial stiffness

Lists of papers included

1) K.M. Herum, I.G. Lunde, B. Skrbic, G. Florholmen, D. Behmen, I. Sjaastad, C.R. Carlson, M.F. Gomez & G. Christensen. Syndecan-4 Signaling via NFAT Regulates Cardiac Myofibroblast Differentiation and Extracellular Matrix Production J Mol Cell Cardiol 2013 Jan;54:73-81.


Editorial comment:  A.M. Samarel: “Syndecan-4: A component of the mechanosensory apparatus of cardiac fibroblasts”. J Mol Cell Cardiol. 2013 Mar;56:19-21.


2) K.M. Herum, I.G. Lunde, B. Skrbic, W. Louch, A. Hasic, S. Boye, A. Unger, S.-H. Brorson, I. Sjaastad, T. Tonnessen, W.A. Linde, M.F. Gomez & G. Christensen. Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart. Cardiovasc Res 2015; 106(2):217-26. Shared last authorship.


Editorial comment: A. Yabluchanskiy, Y. Ma, M.L. Lindsey "Syndecan-4: a novel regulator of collagen synthesis and deptosition in the pressure-overloaded myocardium". Cardiovasc Res 2015 May1:106(2):178-9



3) M.E. Starn, K.M. Herum, Z.A. Rana, B. Skrbic, E.T. Askevold, C.P. Dahl, M. Vistnes, A. Hasic, H. Kvaloy, I. Sjaastad, C.R. Carlson, T. Tönnessen, L. Gullestad, G. Christenssen, I.G. Lunde. Innate immune signalling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart. FEBS J. 2013; 280:2228-2247.


Date of dissertation

12 March 2015


Geir Christensen and Maria F. Gomez