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Yang

Yang de Marinis

Associate professor

Yang

Association between SARS-CoV-2 and exposure risks in health care workers and university employees – a cross-sectional study

Author

  • David Nygren
  • Jonas Norén
  • Yang De Marinis
  • Anna Holmberg
  • Carl-Johan Fraenkel
  • Magnus Rasmussen

Summary, in English

Background

In health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.
Methods

In this cross-sectional study, we investigated association between questionnaire answers on potential exposure situations and SARS-CoV-2-positivity. Health care workers with and without COVID-19-patient contact at nine units at Skåne University Hospitals in Malmö and Lund, Sweden and university employees from Lund University, Sweden were enrolled. To limit impact of health care worker to health care worker transmission, units with known outbreaks were excluded. A SARS-CoV-2-positive case was defined by a previous positive PCR or anti-SARS-CoV-2 IgG in the ZetaGene COVID-19 Antibody Test.
Results

SARS-CoV-2-positivity was detected in 11/51 (22%) health care workers in COVID-19-units, 10/220 (5%) in non-COVID-19-units and 11/192 (6%) University employees (p = .001, Fischer’s exact). In health care workers, SARS-CoV-2-positivity was associated with work in a designated COVID-19-unit (OR 5.7 (95CI 2.1–16)) and caring for COVID-19-patients during the majority of shifts (OR 5.4 (95CI 2.0–15)). In all participants, SARS-CoV-2-positivity was associated with a confirmed COVID-19 case (OR 10 (95CI 2.0–45)) in the household.
Conclusion

Our study confirmed previous findings of elevated risk of acquiring SARS-CoV-2 in health care workers in COVID-19-units, despite exclusion of units with known outbreaks. Interestingly, health care workers in non-COVID-19-units had similar risk as University employees. Further measures to improve the safety of health care workers might be needed.

Department/s

  • Translational infection medicine
  • Infection Medicine (BMC)
  • Genomics, Diabetes and Endocrinology
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Health care related infections in seriously and critically ill patients

Publishing year

2021

Language

English

Publication/Series

Infectious Diseases

Document type

Journal article

Publisher

Informa Healthcare

Topic

  • Infectious Medicine

Status

Epub

Research group

  • Translational infection medicine
  • Genomics, Diabetes and Endocrinology
  • Health care related infections in seriously and critically ill patients

ISBN/ISSN/Other

  • ISSN: 1651-1980