Yang de Marinis
Epigenetics and genome engineering lab
Yang de Marinis, Principle Investigator
Pradeep Bompada, PhD student cadidate
Judit Tomènech Omella, PhD student candidate
Hyperglycamia is the culprit of diabetic complications in various tissues, owning to the complex genetic and epigenetic interactions triggered by glucose, which is the focus of our research. Specifically, we are investigating:
- The underlying glucose-associated epigeentic mechanisms of diabetic kidney dissease and cardiovascular risks.
- Function annotations of single-nucleaotide polymorphism (SNP) risk variants associated with type 2 diabetes.
- Genome engingeering in human induced pluripotent stem cells.
- Detailed investigations on function of candidate mitochondrial genes and proinflammatory genes associated with diabetes and obesity.
To facilitate our investigations, we apply cutting edge technologies that cover genome-wide chromatin immunoprecipitation sequencing, genome editing by CRISPR/Cas9, and various cell biology and molecular genetic methods.
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