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Wathik Alsalim

Physician

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Effect of single-dose DPP-4 inhibitor sitagliptin on β-cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug-naïve, well-controlled type 2 diabetes subjects

Author

  • Wathik Alsalim
  • Olga Göransson
  • Richard D. Carr
  • Roberto Bizzotto
  • Andrea Tura
  • Giovanni Pacini
  • Andrea Mari
  • Bo Ahrén

Summary, in English

To explore the effects of a single dose of the DPP-4 inhibitor sitagliptin on glucose-standardized insulin secretion and β-cell glucose sensitivity after meal ingestion, 12 healthy and 12 drug-naïve, well-controlled type 2 diabetes (T2D) subjects (mean HbA1c 43mmol/mol, 6.2%) received sitagliptin (100mg) or placebo before a meal (525kcal). β-cell function was measured as the insulin secretory rate at a standardized glucose concentration and the β-cell glucose sensitivity (the slope between glucose and insulin secretory rate). Incretin levels were also monitored. Sitagliptin increased standardized insulin secretion, in both healthy and T2D subjects, compared to placebo, but without increasing β-cell glucose sensitivity. Sitagliptin also increased active glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) and reduced total (reflecting the secretion) GIP, but not total GLP-1 levels. We conclude that a single dose of DPP-4 inhibition induces dissociated effects on different aspects of β-cell function and incretin hormones after meal ingestion in both healthy and well-controlled T2D subjects.

Department/s

  • Medicine, Lund
  • Diabetes
  • Protein Phosphorylation
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2018-04

Language

English

Pages

1080-1085

Publication/Series

Diabetes, Obesity and Metabolism

Volume

20

Issue

4

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Keywords

  • Beta cell function
  • DPP-4 inhibitor
  • Incretins
  • Insulin secretion
  • Sitagliptin
  • Type 2 diabetes

Status

Published

Research group

  • Diabetes
  • Protein Phosphorylation

ISBN/ISSN/Other

  • ISSN: 1462-8902