Valeriya Lyssenko

Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes

Olena Fedotkina, Andrea Luk, Ruchi Jain, Rashmi B Prasad, Dmitry Shungin, et al.
(2022) Acta Ophthalmologica, 100
Journal article

Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes

Olena Fedotkina, Ruchi Jain, Rashmi B Prasad, Andrea Luk, Marta García-Ramírez, et al.
(2022) Frontiers in Neuroscience, 16 p.858049-858049
Journal article

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

S. Ramdas, A. Poveda, A. Kurbasic, V. Lyssenko, P.W. Franks, et al.
(2022) American Journal of Human Genetics, 109 p.1366-1387
Journal article

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

A. Mahajan, V. Lyssenko, L. Groop, Andrew P. Morris
(2022) Nature Genetics, 54 p.560-572
Journal article

A saturated map of common genetic variants associated with human height

L. Yengo, G. Hindy, A. Kurbasic, V. Lyssenko, A. Poveda, et al.
(2022) Nature , p.704-712
Journal article

Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

George Hindy, Leif Groop, Valeriya Lyssenko, Olle Melander, Peter M Nilsson, et al.
(2022) American Journal of Human Genetics, 109 p.81-96
Journal article

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

S. Kanoni, A. Poveda, A. Kurbasic, V. Lyssenko, P.W. Franks, et al.
(2022) Genome Biology, 23
Journal article

Reduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes : the PROLONG study

Türküler Özgümüş, Oksana Sulaieva, Leon Eyrich Jessen, Ruchi Jain, Henrik Falhammar, et al.
(2021) Scientific Reports, 11
Journal article

Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes : an IMIRHAPSODY Study

Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetes, 70 p.2683-2693
Journal article

Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications : The DOLCE Study From Northern Ukraine

Olena Fedotkina, Oksana Sulaieva, Turkuler Ozgumus, Liubov Cherviakova, Nadiya Khalimon, et al.
(2021) Frontiers in Genetics, 12
Journal article

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables : an IMI-RHAPSODY study

Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetologia, 64 p.1982-1989
Journal article

The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Alaitz Poveda, Azra Kurbasic, Valeriya Lyssenko, Paul Franks, et al.
(2021) Nature, 600 p.675-679
Journal article

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Vasiliki Lagou, Ulrika Krus, Leif Groop, Tiinamaija Tuomi, Valeriya Lyssenko, et al.
(2021) Nature Communications, 12
Journal article

The trans-ancestral genomic architecture of glycemic traits

J. Chen, Valeriya Lyssenko, Paul Franks, Sölve Elmståhl, Leif Groop, et al.
(2021) Nature Genetics, 53 p.840-860
Journal article

Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells

Türküler Özgümüs, Oksana Sulaieva, Ruchi Jain, Isabella Artner, Valeriya Lyssenko
(2021) Frontiers in cell and developmental biology, 9 p.1-11
Journal article

A diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease

John Molvin, Amra Jujic, Peter M Nilsson, Margret Leosdottir, Ulf Lindblad, et al.
(2020) ESC Heart Failure, 7 p.345-353
Journal article

Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms

Magdalena Keindl, Olena Fedotkina, Elsa du Plessis, Ruchi Jain, Brith Bergum, et al.
(2020) Frontiers in Endocrinology, 11
Journal article

Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Ruchi Jain, Türküler Özgümüş, Troels Mygind Jensen, Elsa du Plessis, Magdalena Keindl, et al.
(2020) Scientific Reports, 10
Journal article

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, et al.
(2019) Diabetes, 68 p.441-456
Journal article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Jason Flannick, Valeriya Lyssenko, Leif Groop, Peter Nilsson, Michael Boehnke
(2019) Nature, 570 p.71-76
Journal article

Characteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project

Maximilian Tremmel, Valeriya Lyssenko, Bengt Zöller, Gunnar Engström, Martin Magnusson, et al.
(2018) Obesity Medicine, 11 p.6-12
Journal article

Perinatal starvation increases risk for diabetic retinopathy in adulthood

Olena Fedotkina, Rashmi Prasad, Ruchi Jain, Liubov Cherviakova, Nadiya Khalimon, et al.
(2018)
Conference paper: abstract

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
(2018) Diabetes, 67 p.1414-1427
Journal article

A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes

Weihua Meng, Kaanan P. Shah, Samuela Pollack, Iiro Toppila, Harry L. Hebert, et al.
(2018) Acta Ophthalmologica, 96 p.811-819
Journal article

Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study

Kasper Olesen, Troels Mygind Jensen, Lars Jorge Diaz, Anne Cathrine Laustrup Møller, Ingrid Willaing, et al.
(2017) Journal of Clinical and Translational Endocrinology, 8 p.1-5
Journal article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Robert A. Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, et al.
(2017) Diabetes, 66 p.2888-2902
Journal article

Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
(2017) Scientific Data, 4
Journal article

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J. Strawbridge, et al.
(2017) PLoS Medicine, 14
Journal article

The genetic landscape of renal complications in type 1 diabetes

Niina Sandholm, Natalie Van Zuydam, Emma Ahlqvist, Thorhildur Juliusdottir, Harshal A. Deshmukh, et al.
(2017) Journal of the American Society of Nephrology, 28 p.557-574
Journal article

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Janina S. Ried, Janina M. Jeff, Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny Van Dongen, et al.
(2016) Nature Communications, 7
Journal article

Impact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

Peter L. Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, et al.
(2016) Endocrine Connections, 5 p.53-60
Journal article

Personalized therapy by phenotype and genotype

Valeriya Lyssenko, Cristina Bianchi, Stefano Del Prato
(2016) Diabetes Care, 39 p.127-136
Journal article

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
(2016) Diabetologia, 59 p.1928-1937
Journal article

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes : An association analysis of polymorphisms and bone in young and elderly women

Gaurav Garg, Fiona E. McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, et al.
(2016) Bone Reports, 4 p.23-27
Journal article

From association to function : MTNR1B

Amélie Bonnefond, Valeriya Lyssenko
(2016) The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation , p.403-421
Book chapter

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.

Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, et al.
(2016) PLoS ONE, 11
Journal article

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
(2016) Diabetes, 65 p.239-254
Journal article

Atrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.

Amra Jujic, Peter Nilsson, Margaretha Persson, Jens Juul Holst, Signe Sørensen Torekov, et al.
(2016) The Journal of clinical endocrinology and metabolism, 101 p.1372-1380
Journal article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

James Dooley, Lei Tian, Susann Schonefeldt, Viviane Delghingaro-Augusto, Josselyn E Garcia-Perez, et al.
(2016) Nature Genetics, 48 p.519-527
Journal article

The genetic architecture of type 2 diabetes

Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, Jasmina Kravic, Paul Franks, et al.
(2016) Nature, 536 p.41-47
Journal article

New genetic loci link adipose and insulin biology to body fat distribution.

Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, et al.
(2015) Nature, 518 p.187-378
Journal article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, et al.
(2015) PLoS Genetics, 11
Journal article

The impact of low-frequency and rare variants on lipid levels.

Ida Surakka, Momoko Horikoshi, Reedik Mägi, Antti-Pekka Sarin, Anubha Mahajan, et al.
(2015) Nature Genetics, 47 p.589-597
Journal article

Genetic studies of body mass index yield new insights for obesity biology.

Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, et al.
(2015) Nature, 518 p.197-401
Journal article

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, et al.
(2015) PLoS Genetics, 11
Journal article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, et al.
(2015) Nature Genetics, 47 p.1415-1415
Journal article

Using genetic variants to assess the relationship between circulating lipids and type 2 diabetes.

Tove Fall, Weijia Xie, Wenny Poon, Hanieh Yaghootkar, Reedik Mägi, et al.
(2015) Diabetes, 64 p.2676-2684
Journal article

Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts

Akram Alyass, Peter Almgren, Mikael Åkerlund, Jonathan Dushoff, Bo Isomaa, et al.
(2015) Diabetologia, 58 p.87-97
Journal article

Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.

Tove Fall, Sara Hägg, Alexander Ploner, Reedik Mägi, Krista Fischer, et al.
(2015) Diabetes, 64 p.1841-1852
Journal article

Genetics of type 2 diabetes : It matters from which parent we inherit the risk

Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
(2015) Review of Diabetic Studies, 12 p.233-242
Journal article review

Variation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans

Jennifer N. Todd, Wenny Poon, Valeriya Lyssenko, Leif Groop, Brendan Nichols, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.688-696
Journal article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below, Kyle J. Gaulton, et al.
(2014) Nature Genetics, 46 p.234-234
Journal article

A Central Role for GRB10 in Regulation of Islet Function in Man.

Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal article

Genetics of diabetes complications.

Sami Alkayyali, Valeriya Lyssenko
(2014) Mammalian Genome, 25 p.384-400
Journal article

Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance

Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, et al.
(2013) Diabetes, 62 p.1730-1737
Journal article

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, et al.
(2013) Diabetes, 62 p.2141-2150
Journal article

Genetic Screening for the Risk of Type 2 Diabetes. Worthless or valuable?

Valeriya Lyssenko, Markku Laakso
(2013) Diabetes Care, 36 p.120-126
Journal article

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

Jason Flannick, Nicola L. Beer, Alexander G. Bick, Vineeta Agarwala, Janne Molnes, et al.
(2013) Nature Genetics, 45 p.1380-1380
Journal article

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, et al.
(2013) PLoS Medicine, 10
Journal article

A link between GIP and osteopontin in adipose tissue and insulin resistance.

Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, et al.
(2013) Diabetes, 62 p.2088-2094
Journal article

Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.

Anna Jonsson, Claes Ladenvall, Tarunveer Singh Ahluwalia, Jasmina Kravic, Ulrika Krus, et al.
(2013) Diabetes, 62 p.2978-2983
Journal article

The human L-type calcium channel Ca(v)1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.

Thomas Reinbothe, Sami Alkayyali, Emma Ahlqvist, Tiinamaija Tuomi, Bo Isomaa, et al.
(2013) Diabetologia, 56 p.340-349
Journal article

Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.

Sami Alkayyali, M Lajer, H Deshmukh, Emma Ahlqvist, H Colhoun, et al.
(2012) Diabetologia
Journal article

Effect of a common variant of the PCSK2 gene on reduced insulin secretion.

Anna Jonsson, B Isomaa, Tiinamaija Tuomi, Jonas Eriksson, Leif Groop, et al.
(2012) Diabetologia
Journal article

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, et al.
(2012) Diabetes, 61 p.1291-1296
Journal article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, et al.
(2012) Nature Genetics, 44 p.981-981
Journal article

Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.

Bilal Omar, Elin Banke, Emilia Guiguis, Lina Kesson, Vincent Manganiello, et al.
(2012) Biochemical and Biophysical Research Communications, 425 p.812-817
Journal article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Alisa K. Manning, Marie-France Hivert, Robert A. Scott, Jonna L. Grimsby, Nabila Bouatia-Naji, et al.
(2012) Nature Genetics, 44 p.81-659
Journal article

A common variant upstream of the PAX6 gene influences islet function in man.

Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Jalal Taneera, Yuedan Zhou, et al.
(2012) Diabetologia, 55 p.94-104
Journal article

Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?

Cecilia Nagorny, Valeriya Lyssenko
(2012) Current Diabetes Reports, 12 p.667-672
Journal article

Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.

Valeriya Lyssenko, Torben Jørgensen, Robert W Gerwien, Torben Hansen, Michael W Rowe, et al.
(2012) Diabetes & Vascular Disease Research, 9 p.59-67
Journal article

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
(2012) Cell Metabolism, 16 p.625-633
Journal article

Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time

Erwin Reiling, Valeriya Lyssenko, Jolanda M. A. Boer, Sandra Imholz, W. Monique M. Verschuren, et al.
(2012) European Journal of Human Genetics, 20 p.696-700
Journal article

Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.

Anders Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, et al.
(2012) Diabetes, 61 p.1726-1733
Journal article

Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus

Magnus Ekelund, Nael Shaat, Peter Almgren, Eva Anderberg, Mona Landin-Olsson, et al.
(2012) Diabetes Research and Clinical Practice, 97 p.394-398
Journal article

A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, et al.
(2012) Cell Metabolism, 16 p.122-134
Journal article

Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.

Emily Sonestedt, Valeriya Lyssenko, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
(2012) The Journal of clinical endocrinology and metabolism, 97 p.810-818
Journal article

Kartläggning av skyddsfaktorer vid typ 1-diabetes har börjat. Vissa patienter tycks skyddade mot sena komplikationer--flera studier pågår.

Valeriya Lyssenko, Peter Nilsson
(2012) Läkartidningen, 109 p.744-745
Journal article

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Rona J. Strawbridge, Josee Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, et al.
(2011) Diabetes, 60 p.2624-2634
Journal article

FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies

Jens K. Hertel, Stefan Johansson, Emily Sonestedt, Anna Jonsson, Rolv T. Lie, et al.
(2011) Diabetes, 60 p.1637-1644
Journal article

Power in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants

Lin T. Guey, Jasmina Kravic, Olle Melander, Noel P. Burtt, Jason M. Laramie, et al.
(2011) Genetic Epidemiology, 35 p.236-246
Journal article

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.

Peter Almgren, M Lehtovirta, B Isomaa, L Sarelin, M R Taskinen, et al.
(2011) Diabetologia, 54 p.2811-2819
Journal article

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Jason L. Vassy, Peter Shrader, Anna Jonsson, Caroline S. Fox, Valeriya Lyssenko, et al.
(2011) Diabetes Research and Clinical Practice, 93 p.76-79
Journal article

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.

Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal article

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal article

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S. Pankow, et al.
(2010) Nature Genetics, 42 p.75-142
Journal article

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, et al.
(2010) Diabetes, 59 p.1266-1275
Conference paper

A meta-analysis of GWA blood glucose after 2 h of OGTT revealed that GIPR is associated with the secretion of insulin based on glucose and ADCY5 is a new susceptibility gene for type 2 diabetes.

N. Bouatia-Naji, R. Saxena, M. F. Hivert, C. Langenberg, T. Tanaka, et al.
(2010) Diabetes & Metabolism, 36 p.3-3
Conference paper: abstract

Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose

Muhammad A. Abdul-Ghani, Michael P. Stern, Valeriya Lyssenko, Tiinamaija Tuomi, Leif Groop, et al.
(2010) Diabetes Care, 33 p.557-561
Journal article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F. Voight, Laura J. Scott, Valgerdur Steinthorsdottir, Andrew P. Morris, Christian Dina, et al.
(2010) Nature Genetics, 42 p.155-579
Journal article

Effect of variants in the RORA gene on risk of type 2 diabetes

Anna Jonsson, Sami Alkayyali, B. Isomaa, T. Tuomi, Leif Groop, et al.
(2010) Diabetologia, 53 p.304-304
Conference paper: abstract

The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2010) Diabetes/Metabolism Research & Reviews, 26 p.280-286
Journal article

Analysis of TBC1D4 in patients with severe insulin resistance

S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, et al.
(2010) Diabetologia, 53 p.1239-1242
Journal article (letter)

A common variant in the PAX6 gene influences islet function in man

Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Targ Elgzyri, Yuedan Zhou, et al.
(2010) Diabetologia, 53 p.297-297
Conference paper: abstract

Influence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man

Tarun Ahluwalia, Claes Ladenvall, Anna Jonsson, Jasmina Kravic, Esa Laurila, et al.
(2010) Diabetologia, 53 p.136-136
Conference paper: abstract

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study

B. Isomaa, B. Forsen, K. Lahti, N. Holmstrom, J. Waden, et al.
(2010) Diabetologia, 53 p.1709-1713
Journal article

Polymorphisms in CACNA1D affect insulin release and channel expression and associate with type 2 diabetes

Thomas Reinbothe, Valeriya Lyssenko, Stefan Lang, Erik Renström
(2010) Diabetologia, 53 p.296-296
Conference paper: abstract

Genome wide association analysis for free fatty acid levels in DGI

Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
(2010) Diabetologia, 53 p.322-322
Conference paper: abstract

Genetic susceptibility for obesity increases the risk of type 2 diabetes and is modified by macronutrient intakes

Gull Rukh, Emily Sonestedt, Valeriya Lyssenko, Amitabh Sharma, Olle Melander, et al.
(2010) Diabetologia, 53 p.50-50
Conference paper: abstract

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
(2010) Nature Genetics, 42 p.32-105
Journal article

GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population

Virve M. Lundgren, Bo Isomaa, Valeriya Lyssenko, Esa Laurila, Pasi Korhonen, et al.
(2010) Diabetes, 59 p.416-422
Journal article

Variants in MTNR1B influence fasting glucose levels

Inga Prokopenko, Claudia Langenberg, Jose C. Florez, Richa Saxena, Nicole Soranzo, et al.
(2009) Nature Genetics, 41 p.77-81
Journal article

Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study

Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2009) Diabetes Care, 32 p.281-286
Journal article

The diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies

M. P. McKenna, Valeriya Lyssenko, M. Rowe, R. Gerwien, J. Kolberg, et al.
(2009) Diabetologia, 52 p.7-7
Conference paper: abstract

Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations

Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Ines Barroso, et al.
(2009) American Journal of Epidemiology, 170 p.537-545
Journal article review

Functional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias

Jussi Naukkarinen, Emma Nilsson, Heikki A. Koistinen, Sanni Soderlund, Valeriya Lyssenko, et al.
(2009) Circulation: Cardiovascular Genetics, 2 p.245-522
Journal article

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.

Hindrik Mulder, Cecilia Nagorny, Valeriya Lyssenko, Leif Groop
(2009) Diabetologia, 52 p.1240-1249
Journal article

Genetics of type 2 diabetes. On overview.

Leif Groop, Valeriya Lyssenko
(2009) Endocrinologia y Nutricion, 56 Suppl 4 p.34-37
Journal article

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.

A Jonsson, F Renström, Valeriya Lyssenko, E Brito, B Isomaa, et al.
(2009) Diabetologia, 52 p.1334-1338
Journal article

Genome-wide association study for type 2 diabetes: clinical applications.

Valeriya Lyssenko, Leif Groop
(2009) Current Opinion in Lipidology, 20 p.87-91
Journal article

Genetic basis of beta-cell dysfunction in man.

Leif Groop, Valeriya Lyssenko
(2009) Diabetes, Obesity and Metabolism, 11 Suppl 4 p.149-158
Journal article

Genome-wide meta-analysis identifies novel genetic loci associated with OGTT-induced post-challenge glucose

C. Langenberg, R. Saxena, M. -F. Hivert, T. Tanaka, J. S. Pankow, et al.
(2009) Diabetologia, 52 p.75-75
Conference paper: abstract

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

N. Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, M. Laakso, et al.
(2009) Diabetologia, 52 p.825-829
Journal article

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

K. Pilgaard, C. B. Jensen, J. H. Schou, Valeriya Lyssenko, L. Wegner, et al.
(2009) Diabetologia, 52 p.1298-1307
Journal article

Disruption of TFB1M impairs insulin secretion in beta cells

Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
(2009) Diabetologia, 52 p.116-116
Conference paper: abstract

Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes

Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
(2009) Diabetologia, 52 p.108-108
Conference paper: abstract

Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus

Hemang Parikh, Valeriya Lyssenko, Leif Groop
(2009) BMC Medical Genomics, 2
Journal article

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.

Anna Jonsson, Bo Isomaa, Tiinamaija Tuomi, Jalal Taneera, S Albert Salehi, et al.
(2009) Diabetes, 58 p.2409-2413
Journal article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Eleftheria Zeggini, Laura J. Scott, Richa Saxena, Benjamin F. Voight, Jonathan L. Marchini, et al.
(2008) Nature Genetics, 40 p.638-645
Journal article

Identification of ten loci associated with height highlights new biological pathways in human growth

Guillaume Lettre, Anne U. Jackson, Christian Gieger, Fredrick R. Schumacher, Sonja I. Berndt, et al.
(2008) Nature Genetics, 40 p.584-591
Journal article

The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism

SK Ylonen, I Salminen, Valeriya Lyssenko, SM Virtanen, Leif Groop, et al.
(2008) European Journal of Clinical Nutrition, 62 p.1432-1439
Journal article

Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes

Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, et al.
(2008) Diabetes, 57 p.1433-1437
Journal article

Interactions between genes and birth size for development of type 2 diabetes

Nicolo Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, E. Kajantie, et al.
(2008) Diabetologia, 51 p.28-28
Conference paper: abstract

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)

J K Hertel, S Johansson, H Raeder, K Midthjell, Valeriya Lyssenko, et al.
(2008) Diabetologia, 51 p.971-977
Journal article

Metabolic effects of novel type 2 diabetes genes in a population aged 18-75 years

Anna Jonsson, B. Isomaa, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop
(2008) Diabetologia, 51 p.31-32
Conference paper: abstract

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

Valeriya Lyssenko, Anna Jonsson, Peter Almgren, Nicolo Pulizzi, Bo Isomaa, et al.
(2008) New England Journal of Medicine, 359 p.2220-2232
Journal article

The search for putative unifying genetic factors for components of the metabolic syndrome.

Marketa Sjögren, Valeriya Lyssenko, Anna Jonsson, Göran Berglund, Peter Nilsson, et al.
(2008) Diabetologia, 51 p.2242-2251
Journal article

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Wei-Min Chen, Michael R Erdos, Anne U Jackson, Richa Saxena, Serena Sanna, et al.
(2008) Journal of Clinical Investigation, Jun 2 p.2620-2628
Journal article

The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update.

Valeriya Lyssenko
(2008) Current Opinion in Clinical Nutrition and Metabolic Care, 11 p.385-392
Journal article

Common variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes

Ekaterine Bakhtadze, Eero Lindholm, Valeriya Lyssenko, H. J. Arnkvist, J. Bolinder, et al.
(2008) Diabetologia, 51 p.117-117
Conference paper: abstract

Is there a unifying genetic factor predisposing to the metabolic syndrome?

Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
(2008) Diabetologia, 51 p.32-33
Conference paper: abstract

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, et al.
(2008) Diabetes, 57 p.3112-3121
Journal article

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, et al.
(2008) Nature Genetics, 40 p.1092-1097
Journal article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
(2007) Journal of Clinical Investigation, 117 p.2155-2163
Journal article

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noel P. Burtt, Paul I. W. de Bakker, et al.
(2007) Science, 316 p.1331-1336
Journal article

Variants in the FFAR1 Gene Are Associated with Beta Cell Function

Martins Kalis, Per Levéen, Valeriya Lyssenko, Peter Almgren, Leif Groop, et al.
(2007) PLoS ONE, 2
Journal article

Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion

Johan Holmkvist, Damon Tojjar, Peter Almgren, Valeriya Lyssenko, C M Lindgren, et al.
(2007) Diabetologia, 50 p.2467-2475
Journal article

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
(2006) Diabetes, 55 p.2890-2895
Journal article

Valeriya Lyssenko

Publications