
Valeriya Lyssenko
Researcher
Publications
Displaying of publications. Sorted by year, then title.
Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes
Olena Fedotkina, Andrea Luk, Ruchi Jain, Rashmi B Prasad, Dmitry Shungin, et al.
(2022) Acta Ophthalmologica, 100
Journal articleNeuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes
Olena Fedotkina, Ruchi Jain, Rashmi B Prasad, Andrea Luk, Marta García-Ramírez, et al.
(2022) Frontiers in Neuroscience, 16 p.858049-858049
Journal articleA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
S. Ramdas, A. Poveda, A. Kurbasic, V. Lyssenko, P.W. Franks, et al.
(2022) American Journal of Human Genetics, 109 p.1366-1387
Journal articleMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A. Mahajan, V. Lyssenko, L. Groop, Andrew P. Morris
(2022) Nature Genetics, 54 p.560-572
Journal articleA saturated map of common genetic variants associated with human height
L. Yengo, G. Hindy, A. Kurbasic, V. Lyssenko, A. Poveda, et al.
(2022) Nature , p.704-712
Journal articleRare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
George Hindy, Leif Groop, Valeriya Lyssenko, Olle Melander, Peter M Nilsson, et al.
(2022) American Journal of Human Genetics, 109 p.81-96
Journal articleImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
S. Kanoni, A. Poveda, A. Kurbasic, V. Lyssenko, P.W. Franks, et al.
(2022) Genome Biology, 23
Journal articleReduced expression of OXPHOS and DNA damage genes is linked to protection from microvascular complications in long-term type 1 diabetes : the PROLONG study
Türküler Özgümüş, Oksana Sulaieva, Leon Eyrich Jessen, Ruchi Jain, Henrik Falhammar, et al.
(2021) Scientific Reports, 11
Journal articleDistinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes : an IMIRHAPSODY Study
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetes, 70 p.2683-2693
Journal articleNovel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications : The DOLCE Study From Northern Ukraine
Olena Fedotkina, Oksana Sulaieva, Turkuler Ozgumus, Liubov Cherviakova, Nadiya Khalimon, et al.
(2021) Frontiers in Genetics, 12
Journal articleReplication and cross-validation of type 2 diabetes subtypes based on clinical variables : an IMI-RHAPSODY study
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, et al.
(2021) Diabetologia, 64 p.1982-1989
Journal articleThe power of genetic diversity in genome-wide association studies of lipids
Sarah E. Graham, Alaitz Poveda, Azra Kurbasic, Valeriya Lyssenko, Paul Franks, et al.
(2021) Nature, 600 p.675-679
Journal articleSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Vasiliki Lagou, Ulrika Krus, Leif Groop, Tiinamaija Tuomi, Valeriya Lyssenko, et al.
(2021) Nature Communications, 12
Journal articleThe trans-ancestral genomic architecture of glycemic traits
J. Chen, Valeriya Lyssenko, Paul Franks, Sölve Elmståhl, Leif Groop, et al.
(2021) Nature Genetics, 53 p.840-860
Journal articleStarvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells
Türküler Özgümüs, Oksana Sulaieva, Ruchi Jain, Isabella Artner, Valeriya Lyssenko
(2021) Frontiers in cell and developmental biology, 9 p.1-11
Journal articleA diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease
John Molvin, Amra Jujic, Peter M Nilsson, Margret Leosdottir, Ulf Lindblad, et al.
(2020) ESC Heart Failure, 7 p.345-353
Journal articleIncreased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
Magdalena Keindl, Olena Fedotkina, Elsa du Plessis, Ruchi Jain, Brith Bergum, et al.
(2020) Frontiers in Endocrinology, 11
Journal articleLiver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
Ruchi Jain, Türküler Özgümüş, Troels Mygind Jensen, Elsa du Plessis, Magdalena Keindl, et al.
(2020) Scientific Reports, 10
Journal articleMultiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, et al.
(2019) Diabetes, 68 p.441-456
Journal articleExome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Jason Flannick, Valeriya Lyssenko, Leif Groop, Peter Nilsson, Michael Boehnke
(2019) Nature, 570 p.71-76
Journal articleCharacteristics and prognosis of healthy severe obesity (HSO) subjects - The Malmo Preventive Project
Maximilian Tremmel, Valeriya Lyssenko, Bengt Zöller, Gunnar Engström, Martin Magnusson, et al.
(2018) Obesity Medicine, 11 p.6-12
Journal articlePerinatal starvation increases risk for diabetic retinopathy in adulthood
Olena Fedotkina, Rashmi Prasad, Ruchi Jain, Liubov Cherviakova, Nadiya Khalimon, et al.
(2018)
Conference paper: abstractA Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
Natalie R van Zuydam, Emma Ahlqvist, Claes Ladenvall, Peter Almgren, Christina-Alexandra Schulz, et al.
(2018) Diabetes, 67 p.1414-1427
Journal articleA genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
Weihua Meng, Kaanan P. Shah, Samuela Pollack, Iiro Toppila, Harry L. Hebert, et al.
(2018) Acta Ophthalmologica, 96 p.811-819
Journal articleSense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes – The PROLONG-Steno study
Kasper Olesen, Troels Mygind Jensen, Lars Jorge Diaz, Anne Cathrine Laustrup Møller, Ingrid Willaing, et al.
(2017) Journal of Clinical and Translational Endocrinology, 8 p.1-5
Journal articleAn Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, et al.
(2017) Diabetes, 66 p.2888-2902
Journal articleData Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
(2017) Scientific Data, 4
Journal articleImpact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Eleanor Wheeler, Aaron Leong, Ching-Ti Liu, Marie-France Hivert, Rona J. Strawbridge, et al.
(2017) PLoS Medicine, 14
Journal articleThe genetic landscape of renal complications in type 1 diabetes
Niina Sandholm, Natalie Van Zuydam, Emma Ahlqvist, Thorhildur Juliusdottir, Harshal A. Deshmukh, et al.
(2017) Journal of the American Society of Nephrology, 28 p.557-574
Journal articleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Janina S. Ried, Janina M. Jeff, Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny Van Dongen, et al.
(2016) Nature Communications, 7
Journal articleImpact of the tcf7l2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia
Peter L. Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, et al.
(2016) Endocrine Connections, 5 p.53-60
Journal articlePersonalized therapy by phenotype and genotype
Valeriya Lyssenko, Cristina Bianchi, Stefano Del Prato
(2016) Diabetes Care, 39 p.127-136
Journal articleCART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
Mia Abels, Matteo Riva, Hedvig Bennet, Emma Ahlqvist, Oleg Dyachok, et al.
(2016) Diabetologia, 59 p.1928-1937
Journal articleGlucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes : An association analysis of polymorphisms and bone in young and elderly women
Gaurav Garg, Fiona E. McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, et al.
(2016) Bone Reports, 4 p.23-27
Journal articleFrom association to function : MTNR1B
Amélie Bonnefond, Valeriya Lyssenko
(2016) The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation , p.403-421
Book chapterA Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.
Valentina Cigliola, Celine Populaire, Ciro L Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, et al.
(2016) PLoS ONE, 11
Journal articleGlucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Lisa Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, et al.
(2016) Diabetes, 65 p.239-254
Journal articleAtrial Natriuretic Peptide in the high normal range is associated with lower prevalence of insulin resistance.
Amra Jujic, Peter Nilsson, Margaretha Persson, Jens Juul Holst, Signe Sørensen Torekov, et al.
(2016) The Journal of clinical endocrinology and metabolism, 101 p.1372-1380
Journal articleGenetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
James Dooley, Lei Tian, Susann Schonefeldt, Viviane Delghingaro-Augusto, Josselyn E Garcia-Perez, et al.
(2016) Nature Genetics, 48 p.519-527
Journal articleThe genetic architecture of type 2 diabetes
Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, Jasmina Kravic, Paul Franks, et al.
(2016) Nature, 536 p.41-47
Journal articleNew genetic loci link adipose and insulin biology to body fat distribution.
Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, et al.
(2015) Nature, 518 p.187-378
Journal articleThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, et al.
(2015) PLoS Genetics, 11
Journal articleThe impact of low-frequency and rare variants on lipid levels.
Ida Surakka, Momoko Horikoshi, Reedik Mägi, Antti-Pekka Sarin, Anubha Mahajan, et al.
(2015) Nature Genetics, 47 p.589-597
Journal articleGenetic studies of body mass index yield new insights for obesity biology.
Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, et al.
(2015) Nature, 518 p.197-401
Journal articleDiscovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, et al.
(2015) PLoS Genetics, 11
Journal articleGenetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, et al.
(2015) Nature Genetics, 47 p.1415-1415
Journal articleUsing genetic variants to assess the relationship between circulating lipids and type 2 diabetes.
Tove Fall, Weijia Xie, Wenny Poon, Hanieh Yaghootkar, Reedik Mägi, et al.
(2015) Diabetes, 64 p.2676-2684
Journal articleModelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts
Akram Alyass, Peter Almgren, Mikael Åkerlund, Jonathan Dushoff, Bo Isomaa, et al.
(2015) Diabetologia, 58 p.87-97
Journal articleAge- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.
Tove Fall, Sara Hägg, Alexander Ploner, Reedik Mägi, Krista Fischer, et al.
(2015) Diabetes, 64 p.1841-1852
Journal articleGenetics of type 2 diabetes : It matters from which parent we inherit the risk
Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
(2015) Review of Diabetic Studies, 12 p.233-242
Journal article reviewVariation in Glucose Homeostasis Traits Associated With P2RX7 Polymorphisms in Mice and Humans
Jennifer N. Todd, Wenny Poon, Valeriya Lyssenko, Leif Groop, Brendan Nichols, et al.
(2015) Journal of Clinical Endocrinology and Metabolism, 100 p.688-696
Journal articleGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below, Kyle J. Gaulton, et al.
(2014) Nature Genetics, 46 p.234-234
Journal articleA Central Role for GRB10 in Regulation of Islet Function in Man.
Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal articleGenetics of diabetes complications.
Sami Alkayyali, Valeriya Lyssenko
(2014) Mammalian Genome, 25 p.384-400
Journal articleEarly Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, et al.
(2013) Diabetes, 62 p.1730-1737
Journal articleGenetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, et al.
(2013) Diabetes, 62 p.2141-2150
Journal articleGenetic Screening for the Risk of Type 2 Diabetes. Worthless or valuable?
Valeriya Lyssenko, Markku Laakso
(2013) Diabetes Care, 36 p.120-126
Journal articleAssessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
Jason Flannick, Nicola L. Beer, Alexander G. Bick, Vineeta Agarwala, Janne Molnes, et al.
(2013) Nature Genetics, 45 p.1380-1380
Journal articleThe Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Tove Fall, Sara Hagg, Reedik Maegi, Alexander Ploner, Krista Fischer, et al.
(2013) PLoS Medicine, 10
Journal articleA link between GIP and osteopontin in adipose tissue and insulin resistance.
Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, et al.
(2013) Diabetes, 62 p.2088-2094
Journal articleEffect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.
Anna Jonsson, Claes Ladenvall, Tarunveer Singh Ahluwalia, Jasmina Kravic, Ulrika Krus, et al.
(2013) Diabetes, 62 p.2978-2983
Journal articleThe human L-type calcium channel Ca(v)1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes.
Thomas Reinbothe, Sami Alkayyali, Emma Ahlqvist, Tiinamaija Tuomi, Bo Isomaa, et al.
(2013) Diabetologia, 56 p.340-349
Journal articleCommon variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
Sami Alkayyali, M Lajer, H Deshmukh, Emma Ahlqvist, H Colhoun, et al.
(2012) Diabetologia
Journal articleEffect of a common variant of the PCSK2 gene on reduced insulin secretion.
Anna Jonsson, B Isomaa, Tiinamaija Tuomi, Jonas Eriksson, Leif Groop, et al.
(2012) Diabetologia
Journal articleNo Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, et al.
(2012) Diabetes, 61 p.1291-1296
Journal articleLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris, Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segre, et al.
(2012) Nature Genetics, 44 p.981-981
Journal articleRegulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.
Bilal Omar, Elin Banke, Emilia Guiguis, Lina Kesson, Vincent Manganiello, et al.
(2012) Biochemical and Biophysical Research Communications, 425 p.812-817
Journal articleA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K. Manning, Marie-France Hivert, Robert A. Scott, Jonna L. Grimsby, Nabila Bouatia-Naji, et al.
(2012) Nature Genetics, 44 p.81-659
Journal articleA common variant upstream of the PAX6 gene influences islet function in man.
Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Jalal Taneera, Yuedan Zhou, et al.
(2012) Diabetologia, 55 p.94-104
Journal articleTired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?
Cecilia Nagorny, Valeriya Lyssenko
(2012) Current Diabetes Reports, 12 p.667-672
Journal articleValidation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
Valeriya Lyssenko, Torben Jørgensen, Robert W Gerwien, Torben Hansen, Michael W Rowe, et al.
(2012) Diabetes & Vascular Disease Research, 9 p.59-67
Journal articleSecreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Taman Mahdi, Sonja Hänzelmann, S Albert Salehi, Sarheed Jabar Muhammed, Thomas Reinbothe, et al.
(2012) Cell Metabolism, 16 p.625-633
Journal articleCodon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
Erwin Reiling, Valeriya Lyssenko, Jolanda M. A. Boer, Sandra Imholz, W. Monique M. Verschuren, et al.
(2012) European Journal of Human Genetics, 20 p.696-700
Journal articleReduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
Anders Rosengren, Matthias Braun, Taman Mahdi, Sofia A Andersson, Mary E Travers, et al.
(2012) Diabetes, 61 p.1726-1733
Journal articleGenetic prediction of postpartum diabetes in women with gestational diabetes mellitus
Magnus Ekelund, Nael Shaat, Peter Almgren, Eva Anderberg, Mona Landin-Olsson, et al.
(2012) Diabetes Research and Clinical Practice, 97 p.394-398
Journal articleA systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, et al.
(2012) Cell Metabolism, 16 p.122-134
Journal articleGenetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
Emily Sonestedt, Valeriya Lyssenko, Ulrika Ericson, Bo Gullberg, Elisabet Wirfält, et al.
(2012) The Journal of clinical endocrinology and metabolism, 97 p.810-818
Journal articleKartläggning av skyddsfaktorer vid typ 1-diabetes har börjat. Vissa patienter tycks skyddade mot sena komplikationer--flera studier pågår.
Valeriya Lyssenko, Peter Nilsson
(2012) Läkartidningen, 109 p.744-745
Journal articleGenome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge, Josee Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, et al.
(2011) Diabetes, 60 p.2624-2634
Journal articleFTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Jens K. Hertel, Stefan Johansson, Emily Sonestedt, Anna Jonsson, Rolv T. Lie, et al.
(2011) Diabetes, 60 p.1637-1644
Journal articlePower in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants
Lin T. Guey, Jasmina Kravic, Olle Melander, Noel P. Burtt, Jason M. Laramie, et al.
(2011) Genetic Epidemiology, 35 p.236-246
Journal articleHeritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
Peter Almgren, M Lehtovirta, B Isomaa, L Sarelin, M R Taskinen, et al.
(2011) Diabetologia, 54 p.2811-2819
Journal articleAssociation between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
Jason L. Vassy, Peter Shrader, Anna Jonsson, Caroline S. Fox, Valeriya Lyssenko, et al.
(2011) Diabetes Research and Clinical Practice, 93 p.76-79
Journal articleA common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal articlePleiotropic Effects of GIP on Islet Function Involve Osteopontin
Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, et al.
(2011) Diabetes, 60 p.2424-2433
Journal articleGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S. Pankow, et al.
(2010) Nature Genetics, 42 p.75-142
Journal articleDetailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, et al.
(2010) Diabetes, 59 p.1266-1275
Conference paperA meta-analysis of GWA blood glucose after 2 h of OGTT revealed that GIPR is associated with the secretion of insulin based on glucose and ADCY5 is a new susceptibility gene for type 2 diabetes.
N. Bouatia-Naji, R. Saxena, M. F. Hivert, C. Langenberg, T. Tanaka, et al.
(2010) Diabetes & Metabolism, 36 p.3-3
Conference paper: abstractMinimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
Muhammad A. Abdul-Ghani, Michael P. Stern, Valeriya Lyssenko, Tiinamaija Tuomi, Leif Groop, et al.
(2010) Diabetes Care, 33 p.557-561
Journal articleTwelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight, Laura J. Scott, Valgerdur Steinthorsdottir, Andrew P. Morris, Christian Dina, et al.
(2010) Nature Genetics, 42 p.155-579
Journal articleEffect of variants in the RORA gene on risk of type 2 diabetes
Anna Jonsson, Sami Alkayyali, B. Isomaa, T. Tuomi, Leif Groop, et al.
(2010) Diabetologia, 53 p.304-304
Conference paper: abstractThe shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2010) Diabetes/Metabolism Research & Reviews, 26 p.280-286
Journal articleAnalysis of TBC1D4 in patients with severe insulin resistance
S. Dash, C. Langenberg, K. A. Fawcett, R. K. Semple, S. Romeo, et al.
(2010) Diabetologia, 53 p.1239-1242
Journal article (letter)A common variant in the PAX6 gene influences islet function in man
Emma Ahlqvist, Fabiola Turrini, Stefan Lang, Targ Elgzyri, Yuedan Zhou, et al.
(2010) Diabetologia, 53 p.297-297
Conference paper: abstractInfluence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man
Tarun Ahluwalia, Claes Ladenvall, Anna Jonsson, Jasmina Kravic, Esa Laurila, et al.
(2010) Diabetologia, 53 p.136-136
Conference paper: abstractA family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
B. Isomaa, B. Forsen, K. Lahti, N. Holmstrom, J. Waden, et al.
(2010) Diabetologia, 53 p.1709-1713
Journal articlePolymorphisms in CACNA1D affect insulin release and channel expression and associate with type 2 diabetes
Thomas Reinbothe, Valeriya Lyssenko, Stefan Lang, Erik Renström
(2010) Diabetologia, 53 p.296-296
Conference paper: abstractGenome wide association analysis for free fatty acid levels in DGI
Ivana Stojkovic, C. Saloranta, Peter Almgren, Valeriya Lyssenko, E. Laurila, et al.
(2010) Diabetologia, 53 p.322-322
Conference paper: abstractGenetic susceptibility for obesity increases the risk of type 2 diabetes and is modified by macronutrient intakes
Gull Rukh, Emily Sonestedt, Valeriya Lyssenko, Amitabh Sharma, Olle Melander, et al.
(2010) Diabetologia, 53 p.50-50
Conference paper: abstractNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josee Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, et al.
(2010) Nature Genetics, 42 p.32-105
Journal articleGAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
Virve M. Lundgren, Bo Isomaa, Valeriya Lyssenko, Esa Laurila, Pasi Korhonen, et al.
(2010) Diabetes, 59 p.416-422
Journal articleVariants in MTNR1B influence fasting glucose levels
Inga Prokopenko, Claudia Langenberg, Jose C. Florez, Richa Saxena, Nicole Soranzo, et al.
(2009) Nature Genetics, 41 p.77-81
Journal articleFasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study
Muhammad A. Abdul-Ghani, Valeriya Lyssenko, Tiinamaija Tuomi, Ralph A. DeFronzo, Leif Groop
(2009) Diabetes Care, 32 p.281-286
Journal articleThe diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies
M. P. McKenna, Valeriya Lyssenko, M. Rowe, R. Gerwien, J. Kolberg, et al.
(2009) Diabetologia, 52 p.7-7
Conference paper: abstractUnderlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Georgia Salanti, Lorraine Southam, David Altshuler, Kristin Ardlie, Ines Barroso, et al.
(2009) American Journal of Epidemiology, 170 p.537-545
Journal article reviewFunctional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias
Jussi Naukkarinen, Emma Nilsson, Heikki A. Koistinen, Sanni Soderlund, Valeriya Lyssenko, et al.
(2009) Circulation: Cardiovascular Genetics, 2 p.245-522
Journal articleMelatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.
Hindrik Mulder, Cecilia Nagorny, Valeriya Lyssenko, Leif Groop
(2009) Diabetologia, 52 p.1240-1249
Journal articleGenetics of type 2 diabetes. On overview.
Leif Groop, Valeriya Lyssenko
(2009) Endocrinologia y Nutricion, 56 Suppl 4 p.34-37
Journal articleAssessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.
A Jonsson, F Renström, Valeriya Lyssenko, E Brito, B Isomaa, et al.
(2009) Diabetologia, 52 p.1334-1338
Journal articleGenome-wide association study for type 2 diabetes: clinical applications.
Valeriya Lyssenko, Leif Groop
(2009) Current Opinion in Lipidology, 20 p.87-91
Journal articleGenetic basis of beta-cell dysfunction in man.
Leif Groop, Valeriya Lyssenko
(2009) Diabetes, Obesity and Metabolism, 11 Suppl 4 p.149-158
Journal articleGenome-wide meta-analysis identifies novel genetic loci associated with OGTT-induced post-challenge glucose
C. Langenberg, R. Saxena, M. -F. Hivert, T. Tanaka, J. S. Pankow, et al.
(2009) Diabetologia, 52 p.75-75
Conference paper: abstractInteraction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
N. Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, M. Laakso, et al.
(2009) Diabetologia, 52 p.825-829
Journal articleThe T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
K. Pilgaard, C. B. Jensen, J. H. Schou, Valeriya Lyssenko, L. Wegner, et al.
(2009) Diabetologia, 52 p.1298-1307
Journal articleDisruption of TFB1M impairs insulin secretion in beta cells
Thomas Köck, Marloes Dekker Nitert, A Olsson, Olga Kotova, Jelena Stamenkovic, et al.
(2009) Diabetologia, 52 p.116-116
Conference paper: abstractHyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
Anders Rosengren, Ramunas Jokubka, Damon Tojjar, Charlotte Granhall, Jonatan Tuncel, et al.
(2009) Diabetologia, 52 p.108-108
Conference paper: abstractPrioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
Hemang Parikh, Valeriya Lyssenko, Leif Groop
(2009) BMC Medical Genomics, 2
Journal articleA variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.
Anna Jonsson, Bo Isomaa, Tiinamaija Tuomi, Jalal Taneera, S Albert Salehi, et al.
(2009) Diabetes, 58 p.2409-2413
Journal articleMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini, Laura J. Scott, Richa Saxena, Benjamin F. Voight, Jonathan L. Marchini, et al.
(2008) Nature Genetics, 40 p.638-645
Journal articleIdentification of ten loci associated with height highlights new biological pathways in human growth
Guillaume Lettre, Anne U. Jackson, Christian Gieger, Fredrick R. Schumacher, Sonja I. Berndt, et al.
(2008) Nature Genetics, 40 p.584-591
Journal articleThe Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism
SK Ylonen, I Salminen, Valeriya Lyssenko, SM Virtanen, Leif Groop, et al.
(2008) European Journal of Clinical Nutrition, 62 p.1432-1439
Journal articleGenetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, et al.
(2008) Diabetes, 57 p.1433-1437
Journal articleInteractions between genes and birth size for development of type 2 diabetes
Nicolo Pulizzi, Valeriya Lyssenko, Anna Jonsson, C. Osmond, E. Kajantie, et al.
(2008) Diabetologia, 51 p.28-28
Conference paper: abstractGenetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
J K Hertel, S Johansson, H Raeder, K Midthjell, Valeriya Lyssenko, et al.
(2008) Diabetologia, 51 p.971-977
Journal articleMetabolic effects of novel type 2 diabetes genes in a population aged 18-75 years
Anna Jonsson, B. Isomaa, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop
(2008) Diabetologia, 51 p.31-32
Conference paper: abstractClinical risk factors, DNA variants, and the development of type 2 diabetes.
Valeriya Lyssenko, Anna Jonsson, Peter Almgren, Nicolo Pulizzi, Bo Isomaa, et al.
(2008) New England Journal of Medicine, 359 p.2220-2232
Journal articleThe search for putative unifying genetic factors for components of the metabolic syndrome.
Marketa Sjögren, Valeriya Lyssenko, Anna Jonsson, Göran Berglund, Peter Nilsson, et al.
(2008) Diabetologia, 51 p.2242-2251
Journal articleVariations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
Wei-Min Chen, Michael R Erdos, Anne U Jackson, Richa Saxena, Serena Sanna, et al.
(2008) Journal of Clinical Investigation, Jun 2 p.2620-2628
Journal articleThe transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update.
Valeriya Lyssenko
(2008) Current Opinion in Clinical Nutrition and Metabolic Care, 11 p.385-392
Journal articleCommon variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes
Ekaterine Bakhtadze, Eero Lindholm, Valeriya Lyssenko, H. J. Arnkvist, J. Bolinder, et al.
(2008) Diabetologia, 51 p.117-117
Conference paper: abstractIs there a unifying genetic factor predisposing to the metabolic syndrome?
Marketa Sjögren, Marju Orho-Melander, Anna Jonsson, Margareta Svensson, Göran Berglund, et al.
(2008) Diabetologia, 51 p.32-33
Conference paper: abstractCommon Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander, Olle Melander, Candace Guiducci, Pablo Perez-Martinez, Dolores Corella, et al.
(2008) Diabetes, 57 p.3112-3121
Journal articleVariants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Haruhiko Osawa, et al.
(2008) Nature Genetics, 40 p.1092-1097
Journal articleMechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, et al.
(2007) Journal of Clinical Investigation, 117 p.2155-2163
Journal articleGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Richa Saxena, Benjamin F. Voight, Valeriya Lyssenko, Noel P. Burtt, Paul I. W. de Bakker, et al.
(2007) Science, 316 p.1331-1336
Journal articleVariants in the FFAR1 Gene Are Associated with Beta Cell Function
Martins Kalis, Per Levéen, Valeriya Lyssenko, Peter Almgren, Leif Groop, et al.
(2007) PLoS ONE, 2
Journal articlePolymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion
Johan Holmkvist, Damon Tojjar, Peter Almgren, Valeriya Lyssenko, C M Lindgren, et al.
(2007) Diabetologia, 50 p.2467-2475
Journal articleCommon single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
Richa Saxena, Lauren Gianniny, Noel P. Burtt, Valeriya Lyssenko, Candace Giuducci, et al.
(2006) Diabetes, 55 p.2890-2895
Journal articleIL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, et al.
(2006) Diabetes, 55 p.2915-2921
Journal articleAnalysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study
H Jansson, Valeriya Lyssenko, A Gustavsson, K Hamberg, B Soderfeldt, et al.
(2006) Swedish Dental Journal, 30 p.17-23
Journal articleAuthors' reply.
Valeriya Lyssenko, Dragi Anevski, Peter Almgren, Leif Groop
(2006) PLoS Medicine, 3 p.271-272
Journal article (letter)Common variants in HNF-1 alpha and risk of type 2 diabetes.
Johan Holmkvist, C Cervin, Valeriya Lyssenko, W Winckler, Dragi Anevski, et al.
(2006) Diabetologia, 49 p.2882-2891
Journal articleGenetic prediction of future type 2 diabetes
Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Marju Orho-Melander, Marketa Sjögren, et al.
(2005) PLoS Medicine, 2 p.1299-1308
Journal article