Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Default user image.

Ulrika Krus

Coordinator

Default user image.

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Author

  • Oliver Kluth
  • Mandy Stadion
  • Pascal Gottmann
  • Heja Aga
  • Markus Jähnert
  • Stephan Scherneck
  • Heike Vogel
  • Ulrika Krus
  • Anett Seelig
  • Charlotte Ling
  • Jantje Gerdes
  • Annette Schürmann

Summary, in English

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Diabetes - Islet Patophysiology
  • Diabetes - Epigenetics

Publishing year

2019

Language

English

Pages

3-3036

Publication/Series

Cell Reports

Volume

26

Issue

11

Document type

Journal article

Publisher

Cell Press

Topic

  • Medical Genetics
  • Endocrinology and Diabetes

Keywords

  • beta-cell proliferation
  • cilia genes
  • human pancreatic islets
  • islet transcriptomics
  • New Zealand Obese mouse
  • pathway enrichment analysis
  • primary cilia
  • type 2 diabetes

Status

Published

Research group

  • Diabetes - Islet Patophysiology
  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 2211-1247