Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

Association between fat intake, physical activity and mortality depending on genetic variation in FTO.

Author

  • Emily Sonestedt
  • Bo Gullberg
  • Ulrika Ericson
  • Elisabet Wirfält
  • Bo Hedblad
  • Marju Orho-Melander

Summary, in English

Objective:We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality.Subjects and methods:Among 22 799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. Leisure-time physical activity was determined from a list of 17 different physical activities in a questionnaire. Body composition was measured using bioelectric impedance method.Results:FTO genotype associated strongly with both fat mass and lean mass (P(trend)<1 × 10(-16) for both) but we found only significant interactions with fat intake, or physical activity, on fat mass (P(interaction)=0.01 and 0.004). No significant interaction between FTO genotype and fat intake (P(interaction)=0.72), or leisure-time physical activity (P(interaction)=0.07), on total mortality were observed. However, we observed a significant interaction between leisure-time physical activity and FTO genotype on cardiovascular mortality (P(interaction)=0.03). The highest vs lowest quintile of physical activity was associated with 46% (95% confidence interval, 17-64%) reduced cardiovascular mortality among TT-carriers (P(trend)=0.004), and 11% reduced cardiovascular mortality among A-allele carriers (P(trend)=0.68).Conclusion:Our results indicate that FTO genotype associates with both fat mass and lean mass, but the level of fat intake and physical activity only modify the association with fat mass. In addition, FTO genotype may modify the association between physical activity and cardiovascular mortality.International Journal of Obesity advance online publication, 21 December 2010; doi:10.1038/ijo.2010.263.

Department/s

  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Cardiovascular Disease
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2011

Language

English

Pages

1041-1049

Publication/Series

International Journal of Obesity

Volume

35

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Nutrition and Dietetics

Status

Published

Research group

  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • Genomics, Diabetes and Endocrinology
  • Diabetes - Cardiovascular Disease

ISBN/ISSN/Other

  • ISSN: 1476-5497