Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the malmö diet and cancer cohort: a prospective study.

Author

  • Peter Wallström
  • Emily Sonestedt
  • Joanna Hlebowicz
  • Ulrika Ericson
  • Isabel Drake
  • Margaretha Persson
  • Bo Gullberg
  • Bo Hedblad
  • Elisabet Wirfält

Summary, in English

BACKGROUND:

The aim of the study was to examine associations between intake of macronutrients and dietary fiber and incident ischemic cardiovascular disease (iCVD) in men and women.



METHODS:

We used data from 8,139 male and 12,535 female participants (aged 44-73 y) of the Swedish population-based Malmö Diet and Cancer cohort. The participants were without history of CVD and diabetes mellitus, and had reported stable dietary habits in the study questionnaire. Diet was assessed by a validated modified diet history method, combining a 7-d registration of cooked meals and cold beverages, a 168-item food questionnaire (covering other foods and meal patterns), and a 1-hour diet interview. Sociodemographic and lifestyle data were collected by questionnaire. iCVD cases, which included coronary events (myocardial infarctions or deaths from chronic ischemic heart disease) and ischemic strokes, were ascertained via national and local registries. Nutrient-disease associations were examined by multivariate Cox regressions.



RESULTS:

During a mean follow-up of 13.5 years, we identified 1,089 male and 687 female iCVD cases. High fiber intakes were associated with lower incidence rates of iCVD in women and of ischemic stroke in men. In post-hoc analysis, we discovered statistically significant interactions between intake of fiber and saturated fat; these interactions also differed between men and women (p<0.001).



CONCLUSIONS:

In this well-defined population, a high fiber intake was associated with lower risk of iCVD, but there were no robust associations between other macronutrients and iCVD risk. Judging from this study, gender-specific nutrient analysis may be preferable in epidemiology.

Department/s

  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Department of Clinical Sciences, Malmö
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2012

Language

English

Publication/Series

PLoS ONE

Volume

7

Issue

2

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics

Status

Published

Research group

  • Nutrition Epidemiology
  • Diabetes - Cardiovascular Disease
  • Internal Medicine - Epidemiology
  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Other

  • ISSN: 1932-6203