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Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.

Author

  • Elisabet Wirfält
  • Cairu Li
  • Jonas Manjer
  • Ulrika Ericson
  • Emily Sonestedt
  • Signe Borgquist
  • Göran Landberg
  • Håkan Olsson
  • Bo Gullberg

Summary, in English

We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P < 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer.

Department/s

  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • Surgery
  • Diabetes - Cardiovascular Disease
  • Pathology, Malmö
  • Breastcancer-genetics
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2011

Language

English

Pages

722-733

Publication/Series

Nutrition and Cancer

Volume

63

Issue

5

Document type

Journal article

Publisher

Lawrence Erlbaum Associates

Topic

  • Nutrition and Dietetics
  • Cancer and Oncology

Status

Published

Research group

  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology
  • Surgery
  • Diabetes - Cardiovascular Disease
  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1532-7914