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Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome

Author

  • Isabel Drake
  • Emily Sonestedt
  • Ulrika Ericson
  • Peter Wallström
  • Marju Orho-Melander

Summary, in English

The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL-and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and iMetS in subjects who were re-examined after 16·7 years (n 2704). Two dietary patterns ('Western' and 'Drinker') were retained and explained 3·2 % of the variation in response variables. The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up. After adjustment for potential confounders, the 'Western' dietary pattern was associated with higher risk of iMetS (hazard ratio Q4 v. Q1: 1·47; 95 % CI 1·23, 1·77; P trend=1·5×10-5). The 'Drinker' dietary pattern primarily explained variation in HDL and was not associated with iMetS. In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables and high-fibre foods is associated with detrimental effects on cardio-metabolic health.

Department/s

  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • Nutrition Epidemiology

Publishing year

2018-05-28

Language

English

Pages

1168-1176

Publication/Series

British Journal of Nutrition

Volume

119

Issue

10

Document type

Journal article

Publisher

Cambridge University Press

Topic

  • Nutrition and Dietetics

Keywords

  • Cardio-metabolic traits
  • Cohorts
  • Dietary patterns
  • Metabolic syndrome
  • Reduced rank regression

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology

ISBN/ISSN/Other

  • ISSN: 0007-1145