Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study

Author

  • Fiona McKenzie
  • Pietro Ferrari
  • Heinz Freisling
  • Veronique Chajes
  • Sabina Rinaldi
  • Jordi de Batlle
  • Christina C. Dahm
  • Kim Overvad
  • Laura Baglietto
  • Laureen Dartois
  • Laure Dossus
  • Pagona Lagiou
  • Dimitrios Trichopoulos
  • Antonia Trichopoulou
  • Vittorio Krogh
  • Salvatore Panico
  • Rosario Tumino
  • Stefano Rosso
  • H. B(As) Bueno-de-Mesquita
  • Anne May
  • Petra H. Peeters
  • Elisabete Weiderpass
  • Genevieve Buckland
  • Maria-Jose Sanchez
  • Carmen Navarro
  • Eva Ardanaz
  • Anne Andersson
  • Malin Sund
  • Ulrika Ericson
  • Elisabet Wirfält
  • Tim J. Key
  • Ruth C. Travis
  • Marc Gunter
  • Elio Riboli
  • Anne-Claire Vergnaud
  • Isabelle Romieu

Summary, in English

Breast cancer is the most common cancer among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated to investigate the joint effect of modifiable lifestyle factors on postmenopausal breast cancer risk. The study included 242,918 postmenopausal women from the multinational European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, with detailed information on diet and lifestyle assessed at baseline. The HLIS was constructed from five factors (diet, physical activity, smoking, alcohol consumption and anthropometry) by assigning scores of 0-4 to categories of each component, for which higher values indicate healthier behaviours. Hazard ratios (HR) were estimated by Cox proportional regression models. During 10.9 years of median follow-up, 7,756 incident breast cancer cases were identified. There was a 3% lower risk of breast cancer per point increase of the HLIS. Breast cancer risk was inversely associated with a high HLIS when fourth versus second (reference) categories were compared [adjusted HR=0.74; 95% confidence interval (CI): 0.66-0.83]. The fourth versus the second category of the HLIS was associated with a lower risk for hormone receptor double positive (adjusted HR=0.81, 95% CI: 0.67-0.98) and hormone receptor double negative breast cancer (adjusted HR=0.60, 95% CI: 0.40-0.90). Findings suggest having a high score on an index of combined healthy behaviours reduces the risk of developing breast cancer among postmenopausal women. Programmes which engage women in long term health behaviours should be supported. What's new? How much does behavior really affect cancer risk? These authors set out to measure just that. First, they created a Healthy Lifestyle Index, which quantified five modifiable behaviors, such as smoking and physical activity. Then, using data from the European Prospective Investigation into Cancer and Nutrition (EPIC), they assigned each participant a score between 0 and 4 on each of the behaviors. It turned out that with each point added to a person's Healthy Lifestyle Index score, breast cancer risk fell by 3%, suggesting that public programs to help women maintain these behaviors could be worthwhile for cancer prevention.

Department/s

  • EXODIAB: Excellence in Diabetes Research in Sweden
  • Nutrition Epidemiology
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • EpiHealth: Epidemiology for Health

Publishing year

2015

Language

English

Pages

2640-2648

Publication/Series

International Journal of Cancer

Volume

136

Issue

11

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cancer and Oncology

Keywords

  • breast cancer
  • healthy index
  • lifestyle
  • prospective studies
  • Europe

Status

Published

Research group

  • Nutrition Epidemiology

ISBN/ISSN/Other

  • ISSN: 0020-7136