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Ulrika Ericson

Ulrika Ericson

Associate professor

Ulrika Ericson

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study


  • Joanna L. Clasen
  • Alicia K. Heath
  • Heleen Van Puyvelde
  • Inge Huybrechts
  • Jin Young Park
  • Pietro Ferrari
  • Mattias Johansson
  • Ghislaine Scelo
  • Arve Ulvik
  • Øivind Midttun
  • Per Magne Ueland
  • Christina C. Dahm
  • Jytte Halkjær
  • Anja Olsen
  • Theron Johnson
  • Verena Katzke
  • Matthias B. Schulze
  • Giovanna Masala
  • Francesco Segrado
  • Maria Santucci De Magistris
  • Carlotta Sacerdote
  • Marga C. Ocké
  • Leila Luján-Barroso
  • Ana Ching-López
  • José María Huerta
  • Eva Ardanaz
  • Pilar Amiano
  • Ulrika Ericson
  • Jonas Manjer
  • Björn Gylling
  • Ingegerd Johansson
  • Julie Schmidt
  • Elisabete Weiderpass
  • Elio Riboli
  • Amanda J. Cross
  • David C. Muller

Summary, in English

Background: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.


  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • LUCC: Lund University Cancer Centre
  • Surgery

Publishing year







American Journal of Clinical Nutrition





Document type

Journal article


Oxford University Press


  • Cancer and Oncology


  • dietary biomarkers
  • kynurenine pathway
  • PLP
  • transsulfuration pathway
  • vitamin B6



Research group

  • Diabetes - Cardiovascular Disease
  • Surgery


  • ISSN: 0002-9165