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Tina Rönn

Tina Rönn

Assistant researcher

Tina Rönn

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Author

  • Elin Hall
  • Petr Volkov
  • Tasnim Dayeh
  • Karl Bacos
  • Tina Rönn
  • Marloes Dekker Nitert
  • Charlotte Ling

Summary, in English

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Department/s

  • Diabetes - Epigenetics
  • EXODIAB: Excellence in Diabetes Research in Sweden

Publishing year

2014

Language

English

Publication/Series

BMC Medicine

Volume

12

Issue

1

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Diabetes - Epigenetics

ISBN/ISSN/Other

  • ISSN: 1741-7015