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Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

Author:
  • Linn Gillberg
  • Alexander Perfilyev
  • Charlotte Brøns
  • Martin Thomasen
  • Louise G Grunnet
  • Petr Volkov
  • Fredrik Rosqvist
  • David Iggman
  • Ingrid Dahlman
  • Ulf Risérus
  • Tina Rönn
  • Emma A Nilsson
  • Allan Vaag
  • Charlotte Ling
Publishing year: 2016-01-11
Language: English
Pages: 799-812
Publication/Series: Diabetologia
Volume: 59
Issue: 4
Document type: Journal article
Publisher: Springer Verlag

Abstract english

Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW.

Keywords

  • Endocrinology and Diabetes

Other

Published
  • Epigenetics and Diabetes
  • ISSN: 1432-0428
Tina Rönn
E-mail: tina [dot] ronn [at] med [dot] lu [dot] se

Assistant researcher

Epigenetics and Diabetes

+46 40 39 12 18

CRC 91-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00