Tina Rönn, post-doc
Integrating DNA methylation with genetic and non-genetic factors in the understanding of type 2 diabetes pathogenesis - with main focus on genes involved in oxidative phosphorylation
Genome wide identification of genetic variants affecting DNA methylation sites and incidence of type 2 diabetes in humans
Investigating common genetic variants in type 2 diabetes susceptibility genes and association with the disease in Han Chinese individuals
Young Investigator´s Award by the Scandinavian Society for the Study of Diabetes (SSSD) 2008
Diabetes Programme at Lund University (DPLU) 2008, 20 000 SEK
Diabetes Programme at Lund University (DPLU) 2007, 20 000 SEK
- Age influences DNA methylation and gene expression of COX7A1 in humanskeletal muscle. Rönn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, Tuomi T, Isomaa B, Groop L, Vaag A, Ling C. Diabetologia. 2008 Jul;51(7):1159-68. Epub 2008 May 17.
- Genetic Variation in ATP5O is Associated with Skeletal Muscle ATP50 mRNA Expression and Glucose Uptake in Young Twins. Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, Allan Vaag, Charlotte Ling. PLoSONE 2009, in press.
- A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. T. Rönn, J. Wen, Z. Yang, B. Lu, Y. Du, L. Groop, R. Hu, C. Ling. Diabetologia 2009, in press.
Retrieved from Lund University's publications database
- Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver
- Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
- Whole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
- A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits
- Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
- Epigenetic markers to further understand insulin resistance
- DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.
- Genome-Wide DNA and Histone Modification Studies in Metabolic Disease
- Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.
- Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
- Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.
- Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.
- Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
- Epigenetic adaptation to regular exercise in humans.
- Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
- Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.
- Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets.
- Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
- Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
- Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
- A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.
- Effect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle.
- Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
- First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
- Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
- A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
- The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
- Two common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
- Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.
- Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
- The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes
- A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
- Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.
- Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
- Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
- Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
- Genetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
- PGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle