Tina Rönn
Assistant researcher
Research interests
My research career started when the field of epigenetics in type 2 Diabetes (T2D) was largely unknown, contributing many of the first publiations in the area. Our research unit within the Lund University Diabetes Centre is at the frontline of epigenetic research and has a unique possibility to combine the latest technologies of epigenetic, genetic and metabolomics research with phenotypic data of large cohorts.
We have identified epigenetic changes in human muscle, fat and pancreatic islets, involved in gene regulation important for glucose metabolism and T2D pathogenesis. We have further shown a link between exercise, DNA methylation and metabolic phenotypes.
Based on the scientific results obtained during my years at Lund University, I propose a model where environmental factors act through epigenetic modifications, under the influence of genetic variation, on tissue specific gene transcription and consequently on metabolic phenotypes and risk of developing T2D. Increased understanding of epigenetic gene regulation in human tissues hold promise to precdict the outcome of an altered environment, which allows for better diagnostic and treatment strategies, and finally to prevent the progression of metabolic diseases.
Selected articles
- Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.
Volkov et al., Diabetes 2017. - Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
Rönn et al., Human Molecular Genetics, 2015. - A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue.
Rönn et al., Plos Genetics 2013.
Publications
Displaying of publications. Sorted by year, then title.
- Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, et al.
(2020) Diabetes, 69 p.2503-2517
Journal article - Linn Gillberg, Tina Rönn, Sine Wanda Jørgensen, Alexander Perfilyev, Line Hjort, et al.
(2019) EBioMedicine, 47 p.341-351
Journal article - Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, et al.
(2019) Scientific Reports, 9
Journal article - Charlotte Ling, Tina Rönn
(2019) Cell Metabolism, 29 p.1028-1044
Journal article review - Alexander Perfilyev
(2018) Lund University, Faculty of Medicine Doctoral Dissertation Series, 2018
Dissertation - Vanessa de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, et al.
(2017) Epigenetics, 12 p.287-295
Journal article - Madhusudhan Bysani, Alexander Perfilyev, Vanessa de Mello, Tina Rönn, Emma Nilsson, et al.
(2017) Epigenomics, 9 p.105-122
Journal article - Petr Volkov, Karl Bacos, Jones K Ofori, Jonathan Lou S Esguerra, Lena Eliasson, et al.
(2017) Diabetes, 66 p.1074-1085
Journal article - Charlotte Ling, Tina Rönn
(2016) Diabetologia, 59 p.2295-2297
Journal article (comment) - Petr Volkov, Anders H. Olsson, Linn Gillberg, Sine W. Jørgensen, Charlotte Brøns, et al.
(2016) PLoS ONE, 11
Journal article - Linn Gillberg, Alexander Perfilyev, Charlotte Brøns, Martin Thomasen, Louise G Grunnet, et al.
(2016) Diabetologia, 59 p.799-812
Journal article - Petr Volkov
(2016)
Dissertation - Charlotte Ling, Tina Rönn
(2015) Epigenomics in Health and Disease , p.255-270
Book chapter - Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, et al.
(2015) BMC Medicine, 13
Journal article - Elin Hall
(2015) Lund University Faculty of Medicine Doctoral Dissertation Series, 2016:3
Dissertation - Tina Rönn, Charlotte Ling
(2015) Epigenomics, 7 p.451-460
Journal article review - Carl Ekman, Targ Elgzyri, Kristoffer Ström, Peter Almgren, Hemang Parikh, et al.
(2015) Journal of Applied Physiology, 119 p.953-960
Journal article - Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
(2015) Human Molecular Genetics, 24 p.3792-3813
Journal article - Sarah Keildson, Joao Fadista, Claes Ladenvall, Asa K. Hedman, Targ Elgzyri, et al.
(2014) Diabetes, 63 p.1154-1165
Journal article - Elin Hall, Petr Volkov, Tasnim Dayeh, Karl Bacos, Tina Rönn, et al.
(2014) BMC Medicine, 12
Journal article - Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Esguerra, Sofia Salo, et al.
(2014) GenomeBiology, 15
Journal article - Charlotte Ling, Tina Rönn
(2014) Drug Discovery Today, 19 p.1015-1018
Journal article review - Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma A Nilsson, et al.
(2014) PLoS Genetics, 10
Journal article - Emma A Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, et al.
(2014) Diabetes, 63 p.2962-2976
Journal article - Melina Claussnitzer, Simon N Dankel, Bernward Klocke, Harald Grallert, Viktoria Glunk, et al.
(2014) Cell, 156 p.343-358
Journal article - Tina Rönn, Petr Volkov, Åsa Tornberg, Targ Elgzyri, Ola Hansson, et al.
(2014) Acta Physiologica, 211 p.188-200
Journal article - Anders H Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, et al.
(2014) PLoS Genetics, 10
Journal article - Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, et al.
(2013) PLoS Genetics, 9
Journal article - Tina Rönn, Charlotte Ling
(2013) Epigenomics, 5 p.603-605
Journal article (comment) - Tasnim Dayeh, Anders H Olsson, Petr Volkov, Peter Almgren, Tina Rönn, et al.
(2013) Diabetologia, 56 p.1036-1046
Journal article - Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
(2012) Diabetes
Journal article - Targ Elgzyri, Hemang Parikh, Yuedan Zhou, Marloes Dekker Nitert, Tina Rönn, et al.
(2012) Journal of Clinical Endocrinology and Metabolism, 97 p.1332-1337
Journal article - Shafqat Ahmad, A Heraclides, Q Sun, Targ Elgzyri, Tina Rönn, et al.
(2012) Diabetic medicine : a journal of the British Diabetic Association, 29 p.377-381
Journal article - Anders H Olsson, Tina Rönn, Claes Ladenvall, Hemang Parikh, Bo Isomaa, et al.
(2011) European Journal of Endocrinology, 164 p.765-771
Journal article - Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal article - Anders H Olsson, Tina Rönn, Tarq Elgzyri, Ola Hansson, Karl-Fredrik Eriksson, et al.
(2011) Molecular Genetics and Metabolism, 103 p.275-281
Journal article - Tina Rönn
(2010) Lund University Faculty of Medicine Doctoral Dissertation Series, 2010:58
Dissertation - Jie Wen, Tina Rönn, Anders H Olsson, Zhen Yang, Bin Lu, et al.
(2010) PLoS ONE, 5
Journal article - Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
(2010) Diabetologia, 53 p.312-312
Conference paper: abstract - Charlotte Brøns, Stine Jacobsen, Emma E Nilsson, Tina Rönn, Christine B Jensen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.3048-3056
Journal article - Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, et al.
(2009) PLoS ONE, 4
Journal article - Peter Osmark, Ola Hansson, Anna Jonsson, Tina Rönn, Leif Groop, et al.
(2009) Diabetologia, 52 p.850-854
Journal article - Tina Rönn, J Wen, Z Yang, B Lu, Y Du, et al.
(2009) Diabetologia, Feb 25 p.830-833
Journal article - Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
(2008) Diabetologia, 51 p.130-130
Conference paper: abstract - Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
(2008) Diabetologia, 51 p.132-132
Conference paper: abstract - Tina Rönn, P Poulsen, Ola Hansson, Johan Holmkvist, Peter Almgren, et al.
(2008) Diabetologia, 51 p.1159-1168
Journal article - Charlotte Ling, S Del Guerra, R Lupi, Tina Rönn, Charlotte Granhall, et al.
(2008) Diabetologia, 51 p.615-622
Journal article - Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, et al.
(2007) Journal of Clinical Investigation, 117 p.3427-3435
Journal article