
Tina Rönn
Assistant researcher

Research interests
My research career started when the field of epigenetics in type 2 Diabetes (T2D) was largely unknown, contributing many of the first publiations in the area. Our research unit within the Lund University Diabetes Centre is at the frontline of epigenetic research and has a unique possibility to combine the latest technologies of epigenetic, genetic and metabolomics research with phenotypic data of large cohorts.
We have identified epigenetic changes in human muscle, fat and pancreatic islets, involved in gene regulation important for glucose metabolism and T2D pathogenesis. We have further shown a link between exercise, DNA methylation and metabolic phenotypes.
Based on the scientific results obtained during my years at Lund University, I propose a model where environmental factors act through epigenetic modifications, under the influence of genetic variation, on tissue specific gene transcription and consequently on metabolic phenotypes and risk of developing T2D. Increased understanding of epigenetic gene regulation in human tissues hold promise to precdict the outcome of an altered environment, which allows for better diagnostic and treatment strategies, and finally to prevent the progression of metabolic diseases.
Selected articles
- Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.
Volkov et al., Diabetes 2017. - Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
Rönn et al., Human Molecular Genetics, 2015. - A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue.
Rönn et al., Plos Genetics 2013.
Publications
Displaying of publications. Sorted by year, then title.
Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?
Charlotte Ling, Karl Bacos, Tina Rönn
(2022) Nature Reviews Endocrinology, 18 p.433-448
Journal article reviewEpigenetic epidemiology and alterations in type 2 diabetes and obesity
Charlotte Ling, Sabrina Ruhrmann, Johanna Säll, Karl Bacos, Tina Rönn
(2022) Epigenetic epidemiology , p.445-474
Book chapterEpigenetic changes in islets of langerhans preceding the onset of diabetes
Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, et al.
(2020) Diabetes, 69 p.2503-2517
Journal articleFasting unmasks differential fat and muscle transcriptional regulation of metabolic gene sets in low versus normal birth weight men
Linn Gillberg, Tina Rönn, Sine Wanda Jørgensen, Alexander Perfilyev, Line Hjort, et al.
(2019) EBioMedicine, 47 p.341-351
Journal articleATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes.
Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, et al.
(2019) Scientific Reports, 9
Journal articleEpigenetics in Human Obesity and Type 2 Diabetes
Charlotte Ling, Tina Rönn
(2019) Cell Metabolism, 29 p.1028-1044
Journal article reviewHuman liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
Vanessa de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, et al.
(2017) Epigenetics, 12 p.287-295
Journal articleEpigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver
Madhusudhan Bysani, Alexander Perfilyev, Vanessa de Mello, Tina Rönn, Emma Nilsson, et al.
(2017) Epigenomics, 9 p.105-122
Journal articleWhole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
Petr Volkov, Karl Bacos, Jones K Ofori, Jonathan Lou S Esguerra, Lena Eliasson, et al.
(2017) Diabetes, 66 p.1074-1085
Journal articleEpigenetic markers to further understand insulin resistance
Charlotte Ling, Tina Rönn
(2016) Diabetologia, 59 p.2295-2297
Journal article (comment)A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits
Petr Volkov, Anders H. Olsson, Linn Gillberg, Sine W. Jørgensen, Charlotte Brøns, et al.
(2016) PLoS ONE, 11
Journal articleAdipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Linn Gillberg, Alexander Perfilyev, Charlotte Brøns, Martin Thomasen, Louise G Grunnet, et al.
(2016) Diabetologia, 59 p.799-812
Journal articleGenome-Wide DNA and Histone Modification Studies in Metabolic Disease
Charlotte Ling, Tina Rönn
(2015) Epigenomics in Health and Disease , p.255-270
Book chapterDNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.
Tina Rönn, Charlotte Ling
(2015) Epigenomics, 7 p.451-460
Journal article reviewLess pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.
Carl Ekman, Targ Elgzyri, Kristoffer Ström, Peter Almgren, Hemang Parikh, et al.
(2015) Journal of Applied Physiology, 119 p.953-960
Journal articleImpact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.
Tina Rönn, Petr Volkov, Linn Gillberg, Milana Kokosar, Alexander Perfilyev, et al.
(2015) Human Molecular Genetics, 24 p.3792-3813
Journal articleGenome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.
Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, et al.
(2015) BMC Medicine, 13
Journal articleExpression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
Sarah Keildson, Joao Fadista, Claes Ladenvall, Asa K. Hedman, Targ Elgzyri, et al.
(2014) Diabetes, 63 p.1154-1165
Journal articleEffects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.
Elin Hall, Petr Volkov, Tasnim Dayeh, Karl Bacos, Tina Rönn, et al.
(2014) BMC Medicine, 12
Journal articleSex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
Elin Hall, Petr Volkov, Tasnim Dayeh, Jonathan Esguerra, Sofia Salo, et al.
(2014) GenomeBiology, 15
Journal articleGenome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma A Nilsson, et al.
(2014) PLoS Genetics, 10
Journal articleEpigenetic adaptation to regular exercise in humans.
Charlotte Ling, Tina Rönn
(2014) Drug Discovery Today, 19 p.1015-1018
Journal article reviewLeveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms.
Melina Claussnitzer, Simon N Dankel, Bernward Klocke, Harald Grallert, Viktoria Glunk, et al.
(2014) Cell, 156 p.343-358
Journal articleExtensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.
Tina Rönn, Petr Volkov, Åsa Tornberg, Targ Elgzyri, Ola Hansson, et al.
(2014) Acta Physiologica, 211 p.188-200
Journal articleAltered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.
Emma A Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, et al.
(2014) Diabetes, 63 p.2962-2976
Journal articleGenome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets.
Anders H Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, et al.
(2014) PLoS Genetics, 10
Journal articleA six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.
Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, et al.
(2013) PLoS Genetics, 9
Journal articleIdentification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
Tasnim Dayeh, Anders H Olsson, Petr Volkov, Peter Almgren, Tina Rönn, et al.
(2013) Diabetologia, 56 p.1036-1046
Journal articleEffect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle.
Tina Rönn, Charlotte Ling
(2013) Epigenomics, 5 p.603-605
Journal article (comment)Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
Marloes Dekker Nitert, Tasnim Dayeh, Peter Volkov, Targ Elgzyri, Elin Hall, et al.
(2012) Diabetes
Journal articleFirst-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
Targ Elgzyri, Hemang Parikh, Yuedan Zhou, Marloes Dekker Nitert, Tina Rönn, et al.
(2012) Journal of Clinical Endocrinology and Metabolism, 97 p.1332-1337
Journal articleTelomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
Shafqat Ahmad, A Heraclides, Q Sun, Targ Elgzyri, Tina Rönn, et al.
(2012) Diabetic Medicine: A journal of the British Diabetic Association, 29 p.377-381
Journal articleTwo common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
Anders H Olsson, Tina Rönn, Claes Ladenvall, Hemang Parikh, Bo Isomaa, et al.
(2011) European Journal of Endocrinology, 164 p.765-771
Journal articleA common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
Thomas Koeck, Anders H Olsson, Marloes Dekker Nitert, Vladimir Sharoyko, Claes Ladenvall, et al.
(2011) Cell Metabolism, 13 p.80-91
Journal articleThe expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
Anders H Olsson, Tina Rönn, Tarq Elgzyri, Ola Hansson, Karl-Fredrik Eriksson, et al.
(2011) Molecular Genetics and Metabolism, 103 p.275-281
Journal articleInvestigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
Jie Wen, Tina Rönn, Anders H Olsson, Zhen Yang, Bin Lu, et al.
(2010) PLoS ONE, 5
Journal articleResistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
Marloes Dekker Nitert, Tasnim Dayeh, Stefan Lang, Targ Elgzyri, Yang De Marinis, et al.
(2010) Diabetologia, 53 p.312-312
Conference paper: abstractDeoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.
Charlotte Brøns, Stine Jacobsen, Emma E Nilsson, Tina Rönn, Christine B Jensen, et al.
(2010) The Journal of clinical endocrinology and metabolism, 95 p.3048-3056
Journal articleThe role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes
Tina Rönn
(2010) Lund University Faculty of Medicine Doctoral Dissertation Series, 2010:58
DissertationUnique splicing pattern of the TCF7L2 gene in human pancreatic islets.
Peter Osmark, Ola Hansson, Anna Jonsson, Tina Rönn, Leif Groop, et al.
(2009) Diabetologia, 52 p.850-854
Journal articleA common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
Tina Rönn, J Wen, Z Yang, B Lu, Y Du, et al.
(2009) Diabetologia, Feb 25 p.830-833
Journal articleGenetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.
Tina Rönn, Pernille Poulsen, Tiinamaija Tuomi, Bo Isomaa, Leif Groop, et al.
(2009) PLoS ONE, 4
Journal articleGenetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
Tina Rönn, P. Poulsen, Leif Groop, A. Vaag, Charlotte Ling
(2008) Diabetologia, 51 p.132-132
Conference paper: abstractPGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle
Anders H Olsson, Tina Rönn, A. Vaag, Leif Groop, P. Poulsen, et al.
(2008) Diabetologia, 51 p.130-130
Conference paper: abstractAge influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
Tina Rönn, P Poulsen, Ola Hansson, Johan Holmkvist, Peter Almgren, et al.
(2008) Diabetologia, 51 p.1159-1168
Journal articleEpigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
Charlotte Ling, S Del Guerra, R Lupi, Tina Rönn, Charlotte Granhall, et al.
(2008) Diabetologia, 51 p.615-622
Journal articleGenetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
Charlotte Ling, Pernille Poulsen, Stina Simonsson, Tina Rönn, Johan Holmkvist, et al.
(2007) Journal of Clinical Investigation, 117 p.3427-3435
Journal article