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Tibor V Varga

Key interests

Lipidomics, systems biology
Machine learning, neural networks, clustering
Missing data
Cardiovascular genetics

Background/biography

Tibor obtained his BSc in Biology (2009, ELTE, Hungary), MSc in Nutrition and Food Sciences (2013, Semmelweis University, Hungary) and PhD in Genetic Epidemiology (2016, Lund University, Sweden) and is currently working as a joint Postdoctoral Fellow at the University of Copenhagen (Prof. Søren Brunak) and Lund University (Prof. Paul Franks & Assoc. Prof. Åsa Tornberg). His fellowship is generously supported by the Novo Nordisk Foundation. During his PhD, Tibor worked primarily with cardiovascular genetics, undertaking genetic association studies with blood lipid level changes, researching gene x environment interactions and analyzing genetic data for various international consortia (GIANT, GLGC, MAGIC, etc.) seeking to understand the genetic architecture of complex metabolic disease. Tibor currently utilizes various machine learning techniques to study lipidomics, the systematic understanding of thousands of lipid molecules in human tissues. Specifically, he investigates the acute and long-term changes in the human lipidome in people undergoing metabolic stress. His further interests include missing data imputation, prediction using various machine learning algorithms and neural networks.

Publications

Retrieved from Lund University's publications database

Latest

All

Publications

Retrieved from Lund University's publications database

2019
- Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
  A.M. Erzurumluoglu, Frida Renström, Tibor V. Varga, Paul Franks, D.J. Liu, et al.
  (2019) Molecular Psychiatry
  Journal article
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
  , Tuomas O Kilpeläinen, Tibor V. Varga, Alaitz Poveda, Paul Franks, et al.
  (2019) Nature Communications
  Journal article
2018
- A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
  Yun J. Sung, Thomas W. Winkler, Lisa de las Fuentes, Amy R. Bentley, Michael R. Brown, et al.
  (2018) American Journal of Human Genetics
  Journal article
- Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
  Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, et al.
  (2018) PLoS ONE
  Journal article
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
  Valérie Turcot, Yingchang Lu, Heather M Highland, Claudia Schurmann, Anne E. Justice, et al.
  (2018) Nature Genetics
  Journal article
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
  Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
  (2018) Nature Genetics
  Journal article
- The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden : the GLACIER Study
  Yan Chen, Angela C. Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, et al.
  (2018) International Journal of Obesity
  Journal article
2017
- A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
  Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
  (2017) Diabetes
  Journal article
- Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
  Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
  (2017) Scientific Data
  Journal article
- Exome-wide association study of plasma lipids in >300,000 individuals
  Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
  (2017) Nature Genetics
  Journal article
- New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
  Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, et al.
  (2017) Circulation: Cardiovascular Genetics
  Journal article
- Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
  Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, et al.
  (2017) International Journal of Epidemiology
  Journal article
- Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
  Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian'an Luan, Evelin Mihailov, et al.
  (2017) PLoS Genetics
  Journal article
- Rare and low-frequency coding variants alter human adult height
  Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R Wood, et al.
  (2017) Nature
  Journal article
- Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
  Thomas R. Webb, Jeanette Erdmann, Kathleen E. Stirrups, Nathan O. Stitziel, Nicholas G D Masca, et al.
  (2017) Journal of the American College of Cardiology
  Journal article
2016
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
  Robert A. Scott, Daniel F. Freitag, Li Li, Audrey Y. Chu, Praveen Surendran, et al.
  (2016) Science Translational Medicine
  Journal article
- Analysis with the exome array identifies multiple new independent variants in lipid loci
  Stavroula Kanoni, Nicholas G D Masca, Kathleen E. Stirrups, Tibor V. Varga, Helen R Warren, et al.
  (2016) Human Molecular Genetics
  Journal article
- Association of Exome Sequences with Cardiovascular Traits among Blacks in the Jackson Heart Study
  Gina M. Peloso, Leslie A. Lange, Tibor V. Varga, Deborah A. Nickerson, Joshua D. Smith, et al.
  (2016) Circulation: Cardiovascular Genetics
  Journal article
- Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
  Nathan O. Stitziel, Kathleen E. Stirrups, Nicholas G D Masca, Jeanette Erdmann, Paola G. Ferrario, et al.
  (2016) New England Journal of Medicine
  Journal article
- Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program
  Tibor V. Varga, Alexandra H. Winters, Kathleen A. Jablonski, Edward S. Horton, Prajakta Khare-Ranade, et al.
  (2016) Circulation: Cardiovascular Genetics
  Journal article
- Do genetic factors modify the relationship between obesity and hypertriglyceridemia?
  Ashfaq Ali, Tibor V Varga, Ivana Stojkovic, Christina-Alexandra Schulz, Göran Hallmans, et al.
  (2016) Circulation: Cardiovascular Genetics
  Journal article
- Genetic Determinants of Dyslipidemia
  Tibor V Varga
  (2016)
  Dissertation
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease
  Johanna Jakobsdottir, Sven J. van der Lee, Joshua C. Bis, Vincent Chouraki, David Li-Kroeger, et al.
  (2016) PLoS Genetics
  Journal article
- The genetic architecture of type 2 diabetes
  , , Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, et al.
  (2016) Nature
  Journal article
- Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
  Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, et al.
  (2016) Nature Genetics
  Journal article
2015
- Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
  Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, et al.
  (2015) Nature Communications
  Journal article
- Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.
  Frida Renström, Robert Koivula, Tibor V Varga, Göran Hallmans, Hindrik Mulder, et al.
  (2015) Diabetologia
  Journal article
2014
- Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study.
  Tibor V Varga, Emily Sonestedt, Dmitry Shungin, Robert Koivula, Göran Hallmans, et al.
  (2014) PLoS Genetics
  Journal article
2013
- Gene × environment interactions in obesity: the state of the evidence.
  Shafqat Ahmad, Tibor V Varga, Paul Franks
  (2013) Human Heredity
  Journal article
- Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
  Shafqat Ahmad, Gull Rukh, Tibor V Varga, Ashfaq Ali, Azra Kurbasic, et al.
  (2013) PLoS Genetics
  Journal article
- Smoking Status, Snus Use, and Variation at the CHRNA5-CHRNA3-CHRNB4 Locus in Relation to Obesity: The GLACIER Study
  Tibor V Varga, Goran Hallmans, Frank B. Hu, Frida Renström, Paul Franks
  (2013) American Journal of Epidemiology
  Journal article
2012
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
  Robert A. Scott, Vasiliki Lagou, Ryan P. Welch, Eleanor Wheeler, May E. Montasser, et al.
  (2012) Nature Genetics
  Journal article

Publications

Retrieved from Lund University's publications database

Dissertation
- Genetic Determinants of Dyslipidemia
  Tibor V Varga
  (2016)
Journal article
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
  , Tuomas O Kilpeläinen, Tibor V. Varga, Alaitz Poveda, Paul Franks, et al.
  (2019) Nature Communications, 10
- Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
  A.M. Erzurumluoglu, Frida Renström, Tibor V. Varga, Paul Franks, D.J. Liu, et al.
  (2019) Molecular Psychiatry
- Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
  Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, et al.
  (2018) PLoS ONE, 13
- The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden : the GLACIER Study
  Yan Chen, Angela C. Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, et al.
  (2018) International Journal of Obesity, p.1-13
- A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
  Yun J. Sung, Thomas W. Winkler, Lisa de las Fuentes, Amy R. Bentley, Michael R. Brown, et al.
  (2018) American Journal of Human Genetics, 102 p.375-400
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
  Anubha Mahajan, Jennifer Wessel, Sara M Willems, Wei Zhao, Neil R Robertson, et al.
  (2018) Nature Genetics, 50 p.559-571
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
  Valérie Turcot, Yingchang Lu, Heather M Highland, Claudia Schurmann, Anne E. Justice, et al.
  (2018) Nature Genetics, 50 p.26-35
- New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals
  Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, et al.
  (2017) Circulation: Cardiovascular Genetics, 10
- Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
  Thomas R. Webb, Jeanette Erdmann, Kathleen E. Stirrups, Nathan O. Stitziel, Nicholas G D Masca, et al.
  (2017) Journal of the American College of Cardiology, 69 p.823-836
- Rare and low-frequency coding variants alter human adult height
  Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R Wood, et al.
  (2017) Nature, 542 p.186-190
- A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk
  Alisa Manning, Claes Ladenvall, Peter Nilsson, Tibor V. Varga, Paul Franks, et al.
  (2017) Diabetes, 66 p.2019-2032
- Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
  Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian'an Luan, Evelin Mihailov, et al.
  (2017) PLoS Genetics, 13
- Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
  Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, et al.
  (2017) International Journal of Epidemiology, 46 p.1211-1222
- Exome-wide association study of plasma lipids in >300,000 individuals
  Dajiang J Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Anubha Mahajan, et al.
  (2017) Nature Genetics, 49 p.1758-1766
- Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
  Jason Flannick, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, et al.
  (2017) Scientific Data, 4
- Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program
  Tibor V. Varga, Alexandra H. Winters, Kathleen A. Jablonski, Edward S. Horton, Prajakta Khare-Ranade, et al.
  (2016) Circulation: Cardiovascular Genetics, 9 p.495-503
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease
  Johanna Jakobsdottir, Sven J. van der Lee, Joshua C. Bis, Vincent Chouraki, David Li-Kroeger, et al.
  (2016) PLoS Genetics, 12
- Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
  Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, et al.
  (2016) Nature Genetics, 48 p.1151-1161
- Association of Exome Sequences with Cardiovascular Traits among Blacks in the Jackson Heart Study
  Gina M. Peloso, Leslie A. Lange, Tibor V. Varga, Deborah A. Nickerson, Joshua D. Smith, et al.
  (2016) Circulation: Cardiovascular Genetics, 9 p.368-374
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
  Robert A. Scott, Daniel F. Freitag, Li Li, Audrey Y. Chu, Praveen Surendran, et al.
  (2016) Science Translational Medicine, 8
- Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
  Nathan O. Stitziel, Kathleen E. Stirrups, Nicholas G D Masca, Jeanette Erdmann, Paola G. Ferrario, et al.
  (2016) New England Journal of Medicine, 374 p.1134-1144
- Do genetic factors modify the relationship between obesity and hypertriglyceridemia?
  Ashfaq Ali, Tibor V Varga, Ivana Stojkovic, Christina-Alexandra Schulz, Göran Hallmans, et al.
  (2016) Circulation: Cardiovascular Genetics, 9 p.162-171
- Analysis with the exome array identifies multiple new independent variants in lipid loci
  Stavroula Kanoni, Nicholas G D Masca, Kathleen E. Stirrups, Tibor V. Varga, Helen R Warren, et al.
  (2016) Human Molecular Genetics, 25 p.4094-4106
- The genetic architecture of type 2 diabetes
  , , Christian Fuchsberger, Tibor V. Varga, Claes Ladenvall, et al.
  (2016) Nature, 536 p.41-47
- Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
  Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, et al.
  (2015) Nature Communications, 6
- Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.
  Frida Renström, Robert Koivula, Tibor V Varga, Göran Hallmans, Hindrik Mulder, et al.
  (2015) Diabetologia, 58 p.997-1005
- Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study.
  Tibor V Varga, Emily Sonestedt, Dmitry Shungin, Robert Koivula, Göran Hallmans, et al.
  (2014) PLoS Genetics, 10
- Gene × environment interactions in obesity: the state of the evidence.
  Shafqat Ahmad, Tibor V Varga, Paul Franks
  (2013) Human Heredity, 75 p.106-115
- Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
  Shafqat Ahmad, Gull Rukh, Tibor V Varga, Ashfaq Ali, Azra Kurbasic, et al.
  (2013) PLoS Genetics, 9
- Smoking Status, Snus Use, and Variation at the CHRNA5-CHRNA3-CHRNB4 Locus in Relation to Obesity: The GLACIER Study
  Tibor V Varga, Goran Hallmans, Frank B. Hu, Frida Renström, Paul Franks
  (2013) American Journal of Epidemiology, 178 p.31-37
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
  Robert A. Scott, Vasiliki Lagou, Ryan P. Welch, Eleanor Wheeler, May E. Montasser, et al.
  (2012) Nature Genetics, 44 p.991-991

11 March 2019

Tibor V Varga

E-mail: tibor [dot] v_varga [at] med [dot] lu [dot] se

Assistant researcher

Genetic and Molecular Epidemiology

Service point:33

Postdoctoral fellow

EXODIAB: Excellence in Diabetes Research in Sweden

My profile in Lund University research portal

Lund University Diabetes Centre, CRC, SUS Malmö, Jan Waldenströms gata 35, House 91:12. SE-214 28 Malmö. Telephone: +46 40 39 10 00