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Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Blood pressure, body size and prostate cancer risk in the Swedish construction workers cohort

Author

  • Tanja Stocks
  • Maria Pia Hergens
  • Anders Englund
  • Weimin Ye
  • Pär Stattin

Summary, in English

Data from prospective studies on blood pressure and prostate cancer risk are limited, and results are inconclusive. Baseline measurements of height, weight and blood pressure were available in 336,159 men in the Swedish Construction Workers cohort. During an average of 22.2 years of follow-up, 10,002 incident cases and 2,601 fatal cases of prostate cancer were identified in National registers. For 5,219 cases, tumor characteristics were available; 2,817 tumors were classified as nonaggressive and 2,402 as aggressive. Relative risks of disease were estimated from Cox regression models, using attained age as time-scale, and adjusting for birth year, smoking status and body mass index (BMI). Top compared to bottom quintile level of systolic or diastolic blood pressure was associated with a significant 15-20% decreased risk of incident prostate cancer (p for trend: systolic < 0.0001, diastolic = 0.3), but blood pressure was not significantly associated with risk of fatal prostate cancer. BMI was not associated with prostate cancer incidence, but was positively associated with fatal prostate cancer; men in the top quintile had a 30% increased risk (p for trend = 0.0004). The associations between blood pressure and BMI and nonaggressive tumors were similar to those of incident prostate cancer, and associations with aggressive tumors were similar to those of fatal prostate cancer. Data from our study suggest that hypertension is associated with a decreased risk of incident prostate cancer, but the explanation for this finding is unclear. Our study support a positive association between overweight and risk of fatal prostate cancer.

Department/s

  • EpiHealth: Epidemiology for Health

Publishing year

2010-10-01

Language

English

Pages

1660-1668

Publication/Series

International Journal of Cancer

Volume

127

Issue

7

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cancer and Oncology

Keywords

  • Blood pressure
  • Body size
  • Cohort studies
  • Overweight
  • Prostatic neoplasms

Status

Published

ISBN/ISSN/Other

  • ISSN: 0020-7136