Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project.

Author

  • Tone Bjørge
  • Annekatrin Lukanova
  • Steinar Tretli
  • Jonas Manjer
  • Hanno Ulmer
  • Tanja Stocks
  • Randi Selmer
  • Gabriele Nagel
  • Martin Almquist
  • Hans Concin
  • Göran Hallmans
  • Håkan Jonsson
  • Christel Häggström
  • Pär Stattin
  • Anders Engeland

Summary, in English

BACKGROUND: No studies have so far evaluated the impact of the metabolic syndrome (MetS) as an entity on ovarian cancer risk. The authors aimed to examine the association between factors in the MetS, individually and combined, and risk of ovarian cancer incidence and mortality. METHODS: Altogether, 290 000 women from Austria, Norway and Sweden were enrolled during 1974-2005, with measurements taken of height, weight, blood pressure and levels of glucose, cholesterol and triglycerides. Relative risks (RRs) of ovarian cancer were estimated using Cox regression for each MetS factor in quintiles and for standardized levels (z-scores), and for a composite z-score for the MetS. RRs were corrected for random error in measurements. RESULTS: During follow-up, 644 epithelial ovarian cancers and 388 deaths from ovarian cancer were identified. There was no overall association between MetS and ovarian cancer risk. Increasing levels of cholesterol [RR 1.52, 95% confidence interval (95% CI) 1.01-2.29, per 1-U increment of z-score] and blood pressure (RR 1.79, 95% CI 1.12-2.86) conferred, however, increased risks of mucinous and endometrioid tumours, respectively. In women below the age of 50 years, there was increased risk of ovarian cancer mortality for MetS (RR 1.52, 95% CI 1.00-2.30). Increasing levels of BMI (RR 1.17, 95% CI 1.01-1.37) conferred increased risk of ovarian cancer mortality in women above the age of 50 years. CONCLUSION: There was no overall association between MetS and ovarian cancer risk. However, increasing levels of cholesterol and blood pressure increased the risks of mucinous and endometrioid tumours, respectively. Increasing levels of BMI conferred an increased risk of ovarian cancer mortality in women above the age of 50 years.

Department/s

  • EpiHealth: Epidemiology for Health
  • Surgery

Publishing year

2011

Language

English

Pages

1667-1677

Publication/Series

International Journal of Epidemiology

Volume

40

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Public Health, Global Health, Social Medicine and Epidemiology

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 1464-3685