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Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Metabolic Factors Associated with Risk of Renal Cell Carcinoma

Author

  • Christel Haggstrom
  • Kilian Rapp
  • Tanja Stocks
  • Jonas Manjer
  • Tone Bjorge
  • Hanno Ulmer
  • Anders Engeland
  • Martin Almqvist
  • Hans Concin
  • Randi Selmer
  • Borje Ljungberg
  • Steinar Tretli
  • Gabriele Nagel
  • Goran Hallmans
  • Hakan Jonsson
  • Par Stattin

Summary, in English

Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

Department/s

  • EpiHealth: Epidemiology for Health
  • Surgery

Publishing year

2013

Language

English

Publication/Series

PLoS ONE

Volume

8

Issue

2

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Surgery

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 1932-6203