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Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Blood pressure and other metabolic syndrome factors and risk of brain tumour in the large population-based Me-Can cohort study.

Author

  • Michael Edlinger
  • Susanne Strohmaier
  • Håkan Jonsson
  • Tone Bjørge
  • Jonas Manjer
  • Wegene T Borena
  • Christel Häggström
  • Anders Engeland
  • Steinar Tretli
  • Hans Concin
  • Gabriele Nagel
  • Randi Selmer
  • Dorthe Johansen
  • Tanja Stocks
  • Göran Hallmans
  • Pär Stattin
  • Hanno Ulmer

Summary, in English

OBJECTIVES:: Brain tumour has few established determinants. We assessed to which extent risk of brain tumour was related to metabolic syndrome factors in adults. METHODS:: In the Me-Can project, 580 000 individuals from Sweden, Austria, and Norway were followed for a median of 10 years after baseline measurement. Data on brain tumours were obtained from national cancer registries. The factors of metabolic syndrome (BMI, SBP and DBP, and blood levels of glucose, cholesterol, and triglycerides), separately and combined, were analysed in quintiles and for transformed z-scores (mean transformed to 0 and standard deviation to 1). Cox proportional hazards multivariate regression models were used, with corrections for measurement error. RESULTS:: During follow-up, 1312 primary brain tumours were diagnosed, predominantly meningioma (n = 348) and high-grade glioma (n = 436). For meningioma, the hazard ratio was increased for z-scores of SBP [hazard ratio = 1.27 per unit standard deviation, 95% confidence interval (CI) 1.03-1.57], of DBP (hazard ratio = 1.29, 95% CI 1.04-1.58), and of the combined metabolic syndrome score (hazard ratio = 1.31, 95% CI 1.11-1.54). An increased risk of high-grade glioma was found for DBP (hazard ratio = 1.23, 95% CI 1.01-1.50) and triglycerides (hazard ratio = 1.35, 95% CI 1.05-1.72). For both meningioma and high-grade glioma, the risk was more than double in the fifth quintiles of DBP compared to the lowest quintile. For meningioma this risk was even larger for SBP. CONCLUSION:: Increased blood pressure was associated with risk of brain tumours, especially of meningiomas.

Department/s

  • EpiHealth: Epidemiology for Health
  • Surgery

Publishing year

2012

Language

English

Pages

290-296

Publication/Series

Journal of Hypertension

Volume

30

Issue

2

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 1473-5598