Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

  • Sofia Christakoudi
  • Panagiota Pagoni
  • Pietro Ferrari
  • Amanda J. Cross
  • Ioanna Tzoulaki
  • David C. Muller
  • Elisabete Weiderpass
  • Heinz Freisling
  • Neil Murphy
  • Laure Dossus
  • Renee Turzanski Fortner
  • Antonio Agudo
  • Kim Overvad
  • Aurora Perez-Cornago
  • Timothy J. Key
  • Paul Brennan
  • Mattias Johansson
  • Anne Tjønneland
  • Jytte Halkjær
  • Marie Christine Boutron-Ruault
  • Fanny Artaud
  • Gianluca Severi
  • Rudolf Kaaks
  • Matthias B. Schulze
  • Manuela M. Bergmann
  • Giovanna Masala
  • Sara Grioni
  • Vittorio Simeon
  • Rosario Tumino
  • Carlotta Sacerdote
  • Guri Skeie
  • Charlotta Rylander
  • Kristin Benjaminsen Borch
  • J. Ramón Quirós
  • Miguel Rodriguez-Barranco
  • Maria Dolores Chirlaque
  • Eva Ardanaz
  • Pilar Amiano
  • Isabel Drake
  • Tanja Stocks
  • Christel Häggström
  • Sophia Harlid
  • Merete Ellingjord-Dale
  • Elio Riboli
  • Konstantinos K. Tsilidis

Summary, in English

Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (±0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.

Department/s

  • Diabetes - Cardiovascular Disease
  • EpiHealth: Epidemiology for Health
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Register-based epidemiology

Publishing year

2021

Language

English

Pages

1637-1651

Publication/Series

International Journal of Cancer

Volume

148

Issue

7

Document type

Journal article

Publisher

John Wiley and Sons

Topic

  • Cancer and Oncology
  • Nutrition and Dietetics

Keywords

  • BMI change
  • cancer
  • middle adulthood
  • weight gain
  • weight loss

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Register-based epidemiology

ISBN/ISSN/Other

  • ISSN: 0020-7136