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Tanja Stocks

Tanja Stocks

Researcher

Tanja Stocks

Components of the metabolic syndrome and colorectal cancer risk; a prospective study

Author

  • T. Stocks
  • A. Lukanova
  • M. Johansson
  • S. Rinaldi
  • R. Palmqvist
  • G. Hallmans
  • R. Kaaks
  • P. Stattin

Summary, in English

Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI>30 kg m-2), hypertension (blood pressure ≥140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose ≥6.1 mmol l-1 or post-load glucose in capillary plasma ≥8.9 mmol l-1). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P trend=0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P=0.090), 1.83 (95% CI 1.00-3.36; P=0.051) and 1.50 (95% CI 0.83-2.71; P=0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.

Publishing year

2008-02-01

Language

English

Pages

304-314

Publication/Series

International Journal of Obesity

Volume

32

Issue

2

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Nutrition and Dietetics
  • Endocrinology and Diabetes

Keywords

  • Blood glucose
  • C-peptide
  • Colorectal neoplasms
  • Insulin resistance
  • Leptin

Status

Published

ISBN/ISSN/Other

  • ISSN: 0307-0565