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Sophie Hellstrand

Sophie Hellstrand

Doctoral student

Sophie Hellstrand

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö diet and cancer cohort

Author

  • Sophie Hellstrand
  • Ulrika Ericson
  • Christina Alexandra Schulz
  • Isabel Drake
  • Bo Gullberg
  • Bo Hedblad
  • Gunnar Engström
  • Marju Orho-Melander
  • Emily Sonestedt

Summary, in English

Background: By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent results regarding genetically elevated high-density lipoprotein-cholesterol (HDL-C), and cardiovascular disease (CVD) risk. Methods: We included 24,799 participants (62 % women, age 44-74 years) from the Malmö Diet and Cancer cohort. During a mean follow-up time of 15 years, 3068 incident CVD cases (1814 coronary and 1254 ischemic stroke) were identified. Genetic risk scores (GRSs) were constructed by combining 80 validated genetic variants associated with higher TG and LDL-C or lower HDL-C. The participants’ dietary intake, assessed by a modified diet history method, was ranked according to a diet quality index that included six dietary components: saturated fat, polyunsaturated fat, fish, fiber, fruit and vegetables, and sucrose. Results: The GRSLDL-C (P=5×10-6) and GRSHDL-C (P = 0.02) but not GRSTG (P = 0.08) were significantly associated with CVD risk. No significant interaction between the GRSs and diet quality was observed on CVD risk (P > 0.39). A high compared to a low diet quality attenuated the association between GRSLDL-C and the risk of incident ischemic stroke (P interaction = 0.01). Conclusion: We found some evidence of an interaction between diet quality and GRSLDL-C on ischemic stroke.

Department/s

  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Family Medicine, Cardiovascular Epidemiology and Lifestyle
  • EXODIAB: Excellence in Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publishing year

2016

Language

English

Publication/Series

Genes & Nutrition

Volume

11

Issue

1

Document type

Journal article

Publisher

New Century Health Publishers

Topic

  • Medical Genetics

Keywords

  • Cholesterol
  • Epidemiology
  • Lipoproteins
  • Nutrition
  • Triglycerides

Status

Published

Research group

  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Family Medicine, Cardiovascular Epidemiology and Lifestyle

ISBN/ISSN/Other

  • ISSN: 1555-8932