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Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

  • Lydia Morell-Azanza
  • Sonia García-Calzón
  • Tara Rendo-Urteaga
  • Nerea Martin-Calvo
  • Maria Chueca
  • José Alfredo Martínez
  • Maria Cristina Azcona-Sanjulián
  • Amelia Marti
Publishing year: 2017
Language: English
Pages: 392-398
Publication/Series: Pediatric Diabetes
Volume: 18
Issue: 5
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P


  • Endocrinology and Diabetes
  • LDL-cholesterol
  • Dietary intervention
  • Pediatrics


  • Epigenetics and Diabetes
  • ISSN: 1399-543X
Sonia Garcia-Calzon
E-mail: sonia [dot] garcia_calzon [at] med [dot] lu [dot] se

Postdoctoral fellow

Epigenetics and Diabetes


Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00