
Sonia García-Calzón
Postdoctoral fellow

Current position
Post-Doctoral Fellow
Research interests
Epigeneetics and genetics in type 2 diabetes and related metabolic diseases.
Personalized medicine in the progression and treatment of type 2 diabetes.
Ongoing projects
Finding blood epigenetic biomarkers to predict the risk of vascular complations and therapeutic response in patients with type 2 diabetes (ANDIS).
Analyzing genome-wide DNA methylation in whole blood using 850K Illumina DNA methylation array to identify epigenetic biomarkers, followed by technical and biological validation.
Perform functional follow-up studies to assess the key role of epigenetic biomarkers in the progression of type 2 diabetes.
Grants
Marie-Curie Individual Fellowship (Horizon 2020), 2016-2018.
Selected publication
García-Calzón S, Moleres A, Gómez-Martinez S, Diaz LE, Bueno G, Campoy C, Martinez JA, Marcos A, Azcona-Sanjulián MC, Zalba G, Marti A; EVASYON study group. Association of telomere length with IL-6 levels during an obesity treatment in adolescents: interaction with the-174G/C polymorphism in the IL-6gene. Pediatr Obes. 2016 Apr 13. doi: 10.1111/ijpo.12136, in press.
García-Calzón S, Zalba G, Ruiz-Canela M, Shivappa N, Hébert JR, Martínez JA, Fitó M, Gómez-Gracia E, Martínez-González MA, Marti A. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y. Am J Clin Nutr. 2015;102:897-904.
García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A. Pro12Ala polymorphism of the PPARγ2 gene interacts with a Mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial. Circ Cardiovasc Genet. 2015;8:91-9.
García-Calzón S, Gea A, Razquin C, Corella D, Lamuela-Raventós RM, Martínez JA, Martínez-González MA, Zalba G, Marti A. Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial. Int J Obes (Lond). 2014;38:177-82.
Publications
Displaying of publications. Sorted by year, then title.
Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns, Which Associate With Future Diabetic Complications
Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, et al.
(2022) Diabetes Care, 45 p.1621-1630
Journal articleType 2 diabetes classification : a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort
Diana Hedevang Christensen, Sia K. Nicolaisen, Emma Ahlqvist, Jacob V. Stidsen, Jens Steen Nielsen, et al.
(2022) BMJ Open Diabetes Research and Care, 10
Journal articleStatin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, Charlotte Ling
(2021) Epigenomics, 13 p.919-925
Journal articleLifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, et al.
(2021) Diabetes, 70 p.854-866
Journal articleEpigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, et al.
(2020) Science Translational Medicine, 12
Journal articleMediterranean Diet and Telomere Length : A Systematic Review and Meta-Analysis
Silvia Canudas, Nerea Becerra-Tomas, Pablo Hernandez-Alonso, Serena Galie, Cindy Leung, et al.
(2020) Advances in Nutrition, 11 p.1544-1554
Journal article reviewDNA methylation in the pathogenesis of type 2 diabetes in humans
Cajsa Davegårdh, Sonia García-Calzón, Karl Bacos, Charlotte Ling
(2018) Molecular Metabolism, 14 p.12-25
Journal articleSerum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children
A. Marti, L. Morell-Azanza, T. Rendo-Urteaga, S. García-Calzón, A. Ojeda-Rodríguez, et al.
(2018) Pediatric Diabetes, 19 p.217-222
Journal articleSex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels
Sonia García-Calzón, Alexander Perfilyev, Vanessa D. de Mello, Jussi Pihlajamäki, Charlotte Ling
(2018) The Journal of clinical endocrinology and metabolism, 103 p.4395-4408
Journal articleDiabetes medication associates with DNA methylation of metformin transporter genes in the human liver
Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa de Mello, Emma A Nilsson, et al.
(2017) Clinical Epigenetics, 9 p.1-9
Journal articleAbnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, et al.
(2017) BMC Medicine, 15 p.1-27
Journal articleSerum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents
Lydia Morell-Azanza, Sonia García-Calzón, Tara Rendo-Urteaga, Nerea Martin-Calvo, Maria Chueca, et al.
(2017) Pediatric Diabetes, 18 p.392-398
Journal articleRole of dietary pattern and obesity on telomere homeostasis
Sonia García-Calzón, Amelia Marti Del Moral
(2017) Telomeres, Diet and Human Disease : Advances and Therapeutic Opportunities , p.133-148
Book chapter