
Sonia García-Calzón
Postdoctoral fellow

Current position
Post-Doctoral Fellow
Research interests
Epigeneetics and genetics in type 2 diabetes and related metabolic diseases.
Personalized medicine in the progression and treatment of type 2 diabetes.
Ongoing projects
Finding blood epigenetic biomarkers to predict the risk of vascular complations and therapeutic response in patients with type 2 diabetes (ANDIS).
Analyzing genome-wide DNA methylation in whole blood using 850K Illumina DNA methylation array to identify epigenetic biomarkers, followed by technical and biological validation.
Perform functional follow-up studies to assess the key role of epigenetic biomarkers in the progression of type 2 diabetes.
Grants
Marie-Curie Individual Fellowship (Horizon 2020), 2016-2018.
Selected publication
García-Calzón S, Moleres A, Gómez-Martinez S, Diaz LE, Bueno G, Campoy C, Martinez JA, Marcos A, Azcona-Sanjulián MC, Zalba G, Marti A; EVASYON study group. Association of telomere length with IL-6 levels during an obesity treatment in adolescents: interaction with the-174G/C polymorphism in the IL-6gene. Pediatr Obes. 2016 Apr 13. doi: 10.1111/ijpo.12136, in press.
García-Calzón S, Zalba G, Ruiz-Canela M, Shivappa N, Hébert JR, Martínez JA, Fitó M, Gómez-Gracia E, Martínez-González MA, Marti A. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y. Am J Clin Nutr. 2015;102:897-904.
García-Calzón S, Martínez-González MA, Razquin C, Corella D, Salas-Salvadó J, Martínez JA, Zalba G, Marti A. Pro12Ala polymorphism of the PPARγ2 gene interacts with a Mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial. Circ Cardiovasc Genet. 2015;8:91-9.
García-Calzón S, Gea A, Razquin C, Corella D, Lamuela-Raventós RM, Martínez JA, Martínez-González MA, Zalba G, Marti A. Longitudinal association of telomere length and obesity indices in an intervention study with a Mediterranean diet: the PREDIMED-NAVARRA trial. Int J Obes (Lond). 2014;38:177-82.
Publications
Displaying of publications. Sorted by year, then title.
Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia García-Calzón, Charlotte Ling
(2021) Epigenomics, 13 p.919-925
Journal articleLifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, et al.
(2021) Diabetes, 70 p.854-866
Journal articleEpigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes
Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, et al.
(2020) Science Translational Medicine, 12
Journal articleMediterranean Diet and Telomere Length : A Systematic Review and Meta-Analysis
Silvia Canudas, Nerea Becerra-Tomas, Pablo Hernandez-Alonso, Serena Galie, Cindy Leung, et al.
(2020) Advances in Nutrition, 11 p.1544-1554
Journal article reviewDNA methylation in the pathogenesis of type 2 diabetes in humans
Cajsa Davegårdh, Sonia García-Calzón, Karl Bacos, Charlotte Ling
(2018) Molecular Metabolism, 14 p.12-25
Journal articleSerum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children
A. Marti, L. Morell-Azanza, T. Rendo-Urteaga, S. García-Calzón, A. Ojeda-Rodríguez, et al.
(2018) Pediatric Diabetes, 19 p.217-222
Journal articleSex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels
Sonia García-Calzón, Alexander Perfilyev, Vanessa D. de Mello, Jussi Pihlajamäki, Charlotte Ling
(2018) The Journal of clinical endocrinology and metabolism, 103 p.4395-4408
Journal articleDiabetes medication associates with DNA methylation of metformin transporter genes in the human liver
Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa de Mello, Emma A Nilsson, et al.
(2017) Clinical Epigenetics, 9 p.1-9
Journal articleAbnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
Cajsa Davegårdh, Christa Broholm, Alexander Perfilyev, Tora Henriksen, Sonia García-Calzón, et al.
(2017) BMC Medicine, 15 p.1-27
Journal articleSerum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents
Lydia Morell-Azanza, Sonia García-Calzón, Tara Rendo-Urteaga, Nerea Martin-Calvo, Maria Chueca, et al.
(2017) Pediatric Diabetes, 18 p.392-398
Journal articleRole of dietary pattern and obesity on telomere homeostasis
Sonia García-Calzón, Amelia Marti Del Moral
(2017) Telomeres, Diet and Human Disease : Advances and Therapeutic Opportunities , p.133-148
Book chapter