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Albert Salehi

S Albert Salehi

Research team manager

Albert Salehi

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Author

  • Jose Marcos Sanches
  • Li Na Zhao
  • Albert Salehi
  • Claes B Wollheim
  • Philipp Kaldis

Summary, in English

Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabolism. Impaired β-cell functions and insulin resistance have been studied extensively resulting in a good understanding of these pathways but much less is known about interorgan crosstalk, which we define as signaling between tissues by secreted factors. Besides hormones and organokines, dysregulated blood glucose and long-lasting hyperglycemia in T2D is associated with changes in metabolism with metabolites from different tissues contributing to the development of this disease. Recent data suggest that metabolites, such as lipids including free fatty acids and amino acids, play important roles in the interorgan crosstalk during the development of T2D. In general, metabolic remodeling affects physiological homeostasis and impacts the development of T2D. Hence, we highlight the importance of metabolic interorgan crosstalk in this review to gain enhanced knowledge of the pathophysiology of T2D, which may lead to new therapeutic approaches to treat this disease.

Department/s

  • Metabolic disorders and liver disease
  • Islet cell physiology
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • Diabetic Complications
  • Genomics, Diabetes and Endocrinology
  • LUCC: Lund University Cancer Centre

Publishing year

2021-11-30

Language

English

Publication/Series

The FEBS Journal

Document type

Journal article review

Publisher

Wiley-Blackwell

Topic

  • Endocrinology and Diabetes

Status

Epub

Research group

  • Metabolic disorders and liver disease
  • Islet cell physiology
  • Diabetic Complications
  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Other

  • ISSN: 1742-464X