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Albert Salehi

S Albert Salehi

Research team manager

Albert Salehi

Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon

Author

  • S Albert Salehi
  • Saleem Qader
  • Eva Grapengiesser
  • Bo Hellman

Summary, in English

It was early proposed that somatostatin-producing delta-cells in pancreatic islets have local inhibitory effects on the release of insulin and glucagon. Recent observations that pulses of insulin and glucagon are antisynchronous make it important to examine the temporal characteristics of glucose-induced somatostatin release. Analysis of 30 s fractions from the perfused rat pancreas indicated that increase of glucose from 3 to 20 mmol/l results in initial suppression of somatostatin release followed by regular 4-5 min pulses. During continued exposure to 20 mmol/l glucose, the pulses of somatostatin overlapped those of insulin with a delay of 30 s. Somatostatin and glucagon pulses were coupled in antisynchronous fashion (phase shift 2.4+/-0.2 min), supporting the idea that the delta-cells have a local inhibitory effect on glucagon release. It was possible to remove the pulses of somatostatin and glucagon with maintenance of the insulin rhythmicity by addition of 1 mumol/l of the P2Y(1) receptor antagonist MRS 2179.

Department/s

  • Islet cell physiology

Publishing year

2007

Language

English

Pages

43-49

Publication/Series

Regulatory Peptides

Volume

144

Issue

1-3

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Keywords

  • Pancreas perfusion
  • MRS 2179
  • Somatostatin pulse
  • Purinoceptor

Status

Published

Research group

  • Islet cell physiology

ISBN/ISSN/Other

  • ISSN: 1873-1686