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Albert Salehi

S Albert Salehi

Research team manager

Albert Salehi

K-ATP-channels and glucagon secretion glucose-regulated

Author

  • Patrik Rorsman
  • S Albert Salehi
  • Fernando Abdulkader
  • Matthias Braun
  • Patrick E. MacDonald

Summary, in English

Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.

Department/s

  • Islet cell physiology

Publishing year

2008

Language

English

Pages

277-284

Publication/Series

Trends in Endocrinology and Metabolism

Volume

19

Issue

8

Document type

Journal article review

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Status

Published

Research group

  • Islet cell physiology

ISBN/ISSN/Other

  • ISSN: 1879-3061