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Rui Simoes. Picture.

Rui Simoes

Rui Simöes, Guest researcher

Rui Simoes. Picture.

Ketogenic diets : from cancer to mitochondrial diseases and beyond

Author

  • Ana F Branco
  • André Ferreira
  • Rui F Simões
  • Sílvia Magalhães-Novais
  • Cheryl Zehowski
  • Elisabeth Cope
  • Ana Marta Silva
  • Daniela Pereira
  • Vilma A Sardão
  • Teresa Cunha-Oliveira

Summary, in English

BACKGROUND: The employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of high fat, moderate protein and low carbohydrates, which favour mitochondrial respiration rather than glycolysis for energy metabolism.DESIGN: This review focuses on how oncological, neurological and mitochondrial disorders have been targeted by ketogenic diets, their metabolic effects, and the possible mechanisms of action on mitochondrial energy homeostasis. The beneficial and adverse effects of the ketogenic diets are also highlighted.RESULTS AND CONCLUSIONS: Although the full mechanism by which ketogenic diets improve oncological and neurological conditions still remains to be elucidated, their clinical efficacy has attracted many new followers, and ketogenic diets can be a good option as a co-adjuvant therapy, depending on the situation and the extent of the disease.

Publishing year

2016-03

Language

English

Pages

98-285

Publication/Series

European Journal of Clinical Investigation

Volume

46

Issue

3

Document type

Journal article review

Publisher

Wiley-Blackwell

Keywords

  • Diet, Ketogenic/methods
  • Energy Metabolism
  • Epilepsy/diet therapy
  • Glycolysis
  • Humans
  • Mitochondria/metabolism
  • Mitochondrial Diseases/diet therapy
  • Neoplasms/diet therapy
  • Nervous System Diseases/diet therapy

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-2972