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Botnia, case/control

The Botnia study was initiated in 1990 on the western coast of Finland in the Gulf of Bothnia with the aim to:

  1. Characterize the early metabolic defects in individuals at risk of developing type 2 diabetes
  2. Identify genetic variants predisposing to type 2 diabetes
  3. Study how the identified genetic markers and biomarkers can predict the development of type 2 diabetes and progression of the disease
  4. Identify means to prevent the development of type 2 diabetes.

A case-control sample consisting of 752 persons with type 2 diabetes and 715 healthy control participants from the Botnia study. Type 2 diabetes was diagnosed according to WHO criteria, with C-peptide concentrations ≥0.3 nmol/l, no GAD antibodies and age at onset >35 but <75 years of age. The control persons had fasting plasma glucose below 6.0 mmol/l and no first or second-degree family history of type 2 diabetes.