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Rashmi Prasad

Rashmi Prasad

Assistant researcher

Rashmi Prasad

Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood

Author

  • Rashmi B Prasad
  • Fay J. Hosking
  • Jayaram Vijayakrishnan
  • Elli Papaemmanuil
  • Rolf Koehler
  • Mel Greaves
  • Eamonn Sheridan
  • Andreas Gast
  • Sally E. Kinsey
  • Tracy Lightfoot
  • Eve Roman
  • Malcolm Taylor
  • Kathy Pritchard-Jones
  • Martin Stanulla
  • Martin Schrappe
  • Claus R. Bartram
  • Richard S Houlston
  • Rajiv Kumar
  • Kari Hemminki

Summary, in English

Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 x10(-22)), 1.80 (P = 5.90 x 10(-28)), and 1.27 (P = 4.90 x 10(-6)), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (OR(per-allele) = 1.53, 95% confidence interval, 1.44-1.62; P(trend) = 3.49 x 10(-42)), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases.

Department/s

  • EpiHealth: Epidemiology for Health

Publishing year

2010-03-04

Language

English

Pages

7-1765

Publication/Series

Blood

Volume

115

Issue

9

Document type

Journal article

Publisher

American Society of Hematology

Keywords

  • Alleles
  • CCAAT-Enhancer-Binding Proteins
  • Case-Control Studies
  • Child
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 7
  • DNA-Binding Proteins
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Germany
  • Humans
  • Ikaros Transcription Factor
  • Male
  • Middle Aged
  • Models, Genetic
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
  • Transcription Factors
  • United Kingdom
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

ISBN/ISSN/Other

  • ISSN: 1528-0020