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Rashmi Prasad

Rashmi Prasad

Assistant researcher

Rashmi Prasad

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Author

  • Amy L. Sherborne
  • Fay J. Hosking
  • Rashmi B Prasad
  • Rajiv Kumar
  • Rolf Koehler
  • Jayaram Vijayakrishnan
  • Elli Papaemmanuil
  • Claus R. Bartram
  • Martin Stanulla
  • Martin Schrappe
  • Andreas Gast
  • Sara E. Dobbins
  • Yussanne Ma
  • Eamonn Sheridan
  • Malcolm Taylor
  • Sally E. Kinsey
  • Tracey Lightfoot
  • Eve Roman
  • Julie A E Irving
  • James M. Allan
  • Anthony V. Moorman
  • Christine J. Harrison
  • Ian P. Tomlinson
  • Sue Richards
  • Martin Zimmermann
  • Csaba Szalai
  • Agnes F Semsei
  • Daniel J Erdelyi
  • Maja Krajinovic
  • Daniel Sinnett
  • Jasmine Healy
  • Anna Gonzalez-Neira
  • Norihiko Kawamata
  • Seishi Ogawa
  • H. Phillip Koeffler
  • Kari Hemminki
  • Mel Greaves
  • Richard S Houlston

Summary, in English

Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

Department/s

  • EpiHealth: Epidemiology for Health

Publishing year

2010-06

Language

English

Pages

4-492

Publication/Series

Nature Genetics

Volume

42

Issue

6

Document type

Journal article

Publisher

Nature Publishing Group

Keywords

  • Case-Control Studies
  • Chromosomes, Human, Pair 9
  • Genes, p16
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

ISBN/ISSN/Other

  • ISSN: 1546-1718