Rashmi Prasad
Assistant researcher
Project
Systems biology of type 2 diabetes
Parent-of-origin effects, fetal programming and gestational diabetes
Team
Rashmi B Prasad, Principal Investigator
Geeti Arora, PhD student (former)
Gad Hatem, PhD student
Olof Asplund, PhD student
Research
Type 2 diabetes is a complex heterogeneous disease whose etiology includes genetic and epigenetic factors interacting with diverse environmental factors. GWAS studies have unearthed >120 risk loci explaining ~15% of heritability. One source of the missing heritability could be the more recent or rare variants with stronger effects segregating in families with a clear transmission of the disease. Another source of missing heritability includes the distinct parent specific transmission where the risk is conferred when transmitted by one parent and not the other. This could relate to intrauterine programming affecting pancreatic development.
Our projects are aimed at identifying these common and rare variants associated with type 2 diabetes and related traits, and their interactions with non-genetic factors. This will be achieved through systems biology approaches using genetic, epigenetic and transcriptomic data and will lead to identification of key pathways leading to pathological glucose levels and T2D risk.
A related question is the transitory diabetes during pregnancy. We are investigating the etiology of gestational diabetes mellitus in European and Asian-Indian populations.
Key focus
Exploring parent-of-origin effects on type 2 diabetes, insulin secretion and related traits.
Fetal programming and pancreatic development
Etiology of gestational diabetes mellitus
Funding
Diabetes Wellness
Direktör Albert Påhlssons Stiftelse
Swedish Research council networking grant
EFSD/Novo Nordisk Programme for Diabetes Research in Europe
Sydvästra Skånes Diabetesförening
Heart and Lung foundation
Publications
Displaying of publications. Sorted by year, then title.
- Luis Rodrigo Cataldo, Neelanjan Vishnu, Tania Singh, Ludivine Bertonnier-Brouty, Sara Bsharat, et al.
(2021) Metabolism: Clinical and Experimental
Journal article - S. Chriett, A. Lindqvist, L. Shcherbina, A. Edlund, M. Abels, et al.
(2021) Molecular and Cellular Endocrinology, 521
Journal article - Olof Asplund
(2021) Lund University, Faculty of Medicine Doctoral Dissertation Series
Dissertation - Olof Asplund, Johan Rung, Leif Groop, Rashmi Prasad B, Ola Hansson
(2020) Database : the journal of biological databases and curation, 2020
Journal article - Genetic variant effects on gene expression in human pancreatic islets and their implications for T2DAna Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B Prasad, Olof Asplund, et al.
(2020) Nature Communications, 11 p.4912-4912
Journal article - Amra Jujić, Naeimeh Atabaki-Pasdar, Peter M Nilsson, Peter Almgren, Liisa Hakaste, et al.
(2020) Diabetologia, 63 p.1043-1054
Journal article - Louise Groth Grunnet, Line Hjort, Daniel Thomas Minja, Omari Abdul Msemo, Sofie Lykke Møller, et al.
(2020) International Journal of Environmental Research and Public Health, 17
Journal article - Solomiia Korchynska, Maria Krassnitzer, Katarzyna Malenczyk, Rashmi B Prasad, Evgenii O Tretiakov, et al.
(2020) EMBO Journal, 39
Journal article - Nael Shaat, Anastasia Katsarou, Bushra Shahida, Rashmi B Prasad, Karl Kristensen, et al.
(2020) PLoS ONE, 15
Journal article - A Lindqvist, L Shcherbina, R B Prasad, M G Miskelly, M Abels, et al.
(2020) Molecular and Cellular Endocrinology, 511
Journal article - Emma Ahlqvist, Rashmi B. Prasad, Leif Groop
(2020) Diabetes, 69 p.2086-2093
Journal article - Xueming Liu, Enrico Maiorino, Arda Halu, Kimberly Glass, Rashmi B. Prasad, et al.
(2020) Nature Communications, 11
Journal article - Yunsung Lee, Kristine L. Haftorn, William R.P. Denault, Haakon E. Nustad, Christian M. Page, et al.
(2020) BMC Genomics, 21
Journal article - Om Prakash Dwivedi, Mikko Lehtovirta, Benoit Hastoy, Vikash Chandra, Nicole A. J. Krentz, et al.
(2019) Nature Genetics , p.1-22
Journal article - Rashmi B Prasad, Emma Ahlqvist, Leif Groop
(2019) Diabetes & metabolic syndrome, 13 p.3065-3067
Journal article - Tania Singh, Jesper K. Colberg, Luis Sarmiento, Patricia Chaves, Lisbeth Hansen, et al.
(2019) Scientific Reports, 9
Journal article - Diego Balboa, Rashmi B Prasad, Leif Groop, Timo Otonkoski
(2019) Diabetologia, 62 p.1329-1336
Journal article review - Line Hjort, Sofie Lykke Møller, Daniel Minja, Omari Msemo, Birgitte Bruun Nielsen, et al.
(2019) BMJ Open, 9
Journal article - Geeti P Arora, Mikael Åkerlund, Charlotte Brøns, Gunn-Helen Moen, Niko S Wasenius, et al.
(2019) Journal of Internal Medicine
Journal article - Christel M Middeldorp, Leif Groop, Rashmi Prasad, Mark I McCarthy
(2019) European Journal of Epidemiology, 34 p.279-300
Journal article - Jalal Taneera, Abdul Khader Mohammed, Sarah Dhaiban, Mawieh Hamad, Rashmi B. Prasad, et al.
(2019) Islets, 11 p.10-20
Journal article - Rashmi B Prasad, Leif Groop
(2019) Journal of Internal Medicine, 285 p.40-48
Journal article review - David W Clark, Rashmi B Prasad, Leif Groop, James F. Wilson
(2019) Nature Communications, 10
Journal article - Tania Singh, Luis Sarmiento, Cheng Luan, Rashmi B. Prasad, Jenny Johansson, et al.
(2018) Genes, 9
Journal article - Fabrizio Mafessoni, Rashmi B Prasad, Leif Groop, Ola Hansson, Kay Prüfer
(2018) Genome Biology and Evolution, 10 p.2697-2708
Journal article - Geeti Arora, Peter Almgren, Charlotte Brøns, Richa G Thaman, Allan Vaag, et al.
(2018) BMC Medical Genomics, 11
Journal article - Amitabh Sharma, Arda Halu, Julius L. Decano, Megha Padi, Yang-yu Liu, et al.
(2018) npj Systems Biology and Applications, 4
Journal article - Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, et al.
(2018) Nature Communications, 9 p.1-11
Journal article - Emma Ahlqvist, Rashmi B. Prasad, Tiinamaija Tuomi, Anders Rosengren, Leif Groop
(2018) The Lancet Diabetes and Endocrinology, 6 p.440-441
Journal article (letter) - Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
(2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
Journal article - Alicia R Martin, Konrad J Karczewski, Sini Kerminen, Mitja I Kurki, Antti-Pekka Sarin, et al.
(2018) American Journal of Human Genetics, 102 p.760-775
Journal article - Rashmi Prasad, Emma Ahlqvist, Leif Groop
(2018) Endocrinology
Book chapter - Mengyin Cai, Pradeep Bompada, Albert Salehi, Juan R. Acosta, Rashmi B. Prasad, et al.
(2018) Biochemical and Biophysical Research Communications, 495 p.1426-1431
Journal article - Gunn Helen Moen, Marissa LeBlanc, Christine Sommer, Rashmi B. Prasad, Tove Lekva, et al.
(2018) European Journal of Endocrinology, 179 p.363-372
Journal article - Jalal Taneera, Rashmi B Prasad, Sarah Dhaiban, Abdul Khader Mohammed, Leena Haataja, et al.
(2018) Molecular and Cellular Endocrinology, 472 p.10-17
Journal article - Peter Almgren, Andreas Lindqvist, Ulrika Krus, Liisa H. Hakaste, Emilia Ottosson Laakso, et al.
(2017) JCI Insight, 2
Journal article - G. P. Arora, P Almgren, R. G. Thaman, A. Pal, Leif Groop, et al.
(2017) Diabetic medicine : a journal of the British Diabetic Association, 34 p.1477-1482
Journal article - Emilia Ottosson-Laakso, Ulrika Krus, Petter Storm, Rashmi B Prasad, Nikolay Oskolkov, et al.
(2017) Diabetes, 66 p.3013-3028
Journal article - Gunn Helen Moen, Christine Sommer, Rashmi B. Prasad, Line Sletner, Leif Groop, et al.
(2017) European Journal of Endocrinology, 176 p.247-267
Journal article review - Rashmi B. Prasad, Leif Groop
(2017) Textbook of Diabetes
Book chapter - Rashmi B. Prasad, Leif Groop
(2016) Cell Metabolism, 24 p.523-524
Journal article - Rashmi B. Prasad, Anna Lessmark, Peter Almgren, Györgyi Kovacs, Ola Hansson, et al.
(2016) Diabetologia, 59 p.1702-1713
Journal article - Rashmi Prasad, Leif Groop
(2015) Genes, 6 p.87-123
Journal article review - Geeti Arora, Richa G Thaman, Rashmi Prasad, Peter Almgren, Charlotte Brøns, et al.
(2015) European Journal of Endocrinology, 173 p.257-267
Journal article - Valeriya Lyssenko, Leif Groop, Rashmi B. Prasad
(2015) Review of Diabetic Studies, 12 p.233-242
Journal article review - Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad, S Albert Salehi, et al.
(2014) PLoS Genetics, 10
Journal article - Joao Fadista, Petter Vikman, Emilia Ottosson Laakso, Ines Mollet, Jonathan Esguerra, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.13924-13929
Journal article - Barbara Pardini, Rajiv Kumar, Alessio Naccarati, Rashmi B. Prasad, Asta Forsti, et al.
(2011) Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 721 p.74-80
Journal article - Barbara Pardini, Rajiv Kumar, Alessio Naccarati, Jan Novotny, Rashmi B. Prasad, et al.
(2011) British Journal of Clinical Pharmacology, 72 p.162-163
Journal article (letter) - Amy L. Sherborne, Fay J. Hosking, Rashmi B Prasad, Rajiv Kumar, Rolf Koehler, et al.
(2010) Nature Genetics, 42 p.4-492
Journal article - Rashmi B Prasad, Fay J. Hosking, Jayaram Vijayakrishnan, Elli Papaemmanuil, Rolf Koehler, et al.
(2010) Blood, 115 p.7-1765
Journal article - H C Harsha, Shubha Suresh, Ramars Amanchy, Nandan Deshpande, K Shanker, et al.
(2005) Nature Genetics, 37 p.2-331
Journal article (comment) - J Daniel Navarro, Naveen Talreja, Suraj Peri, B M Vrushabendra, BP Rashmi, et al.
(2004) BMC Bioinformatics, 5
Journal article - Suraj Peri, J Daniel Navarro, Troels Z Kristiansen, Ramars Amanchy, Vineeth Surendranath, et al.
(2004) Nucleic Acids Research, 32 p.497-501
Journal article - Suraj Peri, J Daniel Navarro, Ramars Amanchy, Troels Z Kristiansen, Chandra Kiran Jonnalagadda, et al.
(2003) Genome Research, 13 p.71-2363
Journal article