Systems biology of type 2 diabetes
Parent-of-origin effects, fetal programming and gestational diabetes
Rashmi B Prasad, Principal Investigator
Geeti Arora, PhD student (former)
Gad Hatem, PhD student
Olof Asplund, PhD student
Type 2 diabetes is a complex heterogeneous disease whose etiology includes genetic and epigenetic factors interacting with diverse environmental factors. GWAS studies have unearthed >120 risk loci explaining ~15% of heritability. One source of the missing heritability could be the more recent or rare variants with stronger effects segregating in families with a clear transmission of the disease. Another source of missing heritability includes the distinct parent specific transmission where the risk is conferred when transmitted by one parent and not the other. This could relate to intrauterine programming affecting pancreatic development.
Our projects are aimed at identifying these common and rare variants associated with type 2 diabetes and related traits, and their interactions with non-genetic factors. This will be achieved through systems biology approaches using genetic, epigenetic and transcriptomic data and will lead to identification of key pathways leading to pathological glucose levels and T2D risk.
A related question is the transitory diabetes during pregnancy. We are investigating the etiology of gestational diabetes mellitus in European and Asian-Indian populations.
Exploring parent-of-origin effects on type 2 diabetes, insulin secretion and related traits.
Fetal programming and pancreatic development
Etiology of gestational diabetes mellitus
Direktör Albert Påhlssons Stiftelse
Swedish Research council networking grant
EFSD/Novo Nordisk Programme for Diabetes Research in Europe
Sydvästra Skånes Diabetesförening
Heart and Lung foundation
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