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Pontus Dunér

Assistant researcher

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Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Author

  • Isabel Goncalves
  • Eva Bengtsson
  • Helen M Colhoun
  • Angela C Shore
  • Carlo Palombo
  • Andrea Natali
  • Andreas Edsfeldt
  • Pontus Dunér
  • Gunilla Nordin Fredrikson
  • Harry Björkbacka
  • Gerd Östling
  • Kunihiko Aizawa
  • Francesco Casanova
  • Margaretha Persson
  • Kim Gooding
  • David Strain
  • Faisel Kahn
  • Helen C Looker
  • Fiona Adams
  • Jill Belch
  • Silvia Pinnoli
  • Elena Venturi
  • Michaela Kozakova
  • Li-Ming Gan
  • Volker Schnecke
  • Jan Nilsson

Summary, in English

Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.

Department/s

  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health
  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Internal Medicine - Epidemiology

Publishing year

2015

Language

English

Pages

1723-1731

Publication/Series

Arteriosclerosis, Thrombosis and Vascular Biology

Volume

35

Issue

7

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Cardiac and Cardiovascular Systems

Status

Published

Research group

  • Cardiovascular Research - Immunity and Atherosclerosis
  • Cardiovascular Research - Matrix and Inflammation in Atherosclerosis
  • Internal Medicine - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1524-4636