Philipp Kaldis

Histidine protonation states are key in the LigI catalytic reaction mechanism

Lina Zhao, Dibyendu Mondal, Weifeng Li, Yuguang Mu, Philipp Kaldis
(2022) Proteins, 90 p.123-130
Journal article

Pairing structural reconstruction with catalytic competence to evaluate the mechanisms of key enzymes in the folate-mediated one-carbon pathway

Li Na Zhao, Philipp Kaldis
(2022) The FEBS Journal
Journal article review

Editorial : Editor's Pick 2021: Highlights in Cell Growth and Division

Philipp Kaldis
(2022) Frontiers in cell and developmental biology, 10 p.1-1
Journal article (comment)

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Jose Marcos Sanches, Li Na Zhao, Albert Salehi, Claes B Wollheim, Philipp Kaldis
(2021) The FEBS Journal
Journal article review

Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential

Li Na Zhao, Mikael Björklund, Matias J Caldez, Jie Zheng, Philipp Kaldis
(2021) Oncogene
Journal article review

Protective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis

Jianliang Xu, P Jaya Kausalya, Noémi Van Hul, Matias J Caldez, Shiyi Xu, et al.
(2021) Gastroenterology, 160 p.2103-2118
Journal article

Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

Jin Rong Ow, Matias J Cadez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, et al.
(2020) eLife, 9
Journal article

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, et al.
(2020) Nature Communications, 11
Journal article

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, et al.
(2020) PLoS Genetics, 16 p.1009084-1009084
Journal article

Less-well known functions of cyclin/CDK complexes

Nathan Palmer, Philipp Kaldis
(2020) Seminars in Cell & Developmental Biology, 107 p.54-62
Journal article review

Cyclin-dependent kinase 1 is essential for muscle regeneration and overload muscle fiber hypertrophy

Yutaka Kobayashi, Tomoyuki Tanaka, Mieradilli Mulati, Hiroki Ochi, Shingo Sato, et al.
(2020) Frontiers in cell and developmental biology, 8
Journal article

MetaboKit : a comprehensive data extraction tool for untargeted metabolomics

Pradeep Narayanaswamy, Guoshou Teo, Jin Rong Ow, Adam Lau, Philipp Kaldis, et al.
(2020) Molecular omics, 16 p.436-447
Journal article

The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

Xavier Bisteau, Joann Lee, Vinayaka Srinivas, Joanna H.S. Lee, Joanna Niska-Blakie, et al.
(2020) Oncogene
Journal article

Cascading proton transfers are a hallmark of the catalytic mechanism of SAM-dependent methyltransferases

Li Na Zhao, Philipp Kaldis
(2020) FEBS Letters, 594 p.2128-2139
Journal article

Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division : when imbalanced metabolism limits cell division

Matias J Caldez, Mikael Bjorklund, Philipp Kaldis
(2020) Hepatology international, 14 p.463-474
Journal article review

Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia

Joel H L Tan, Heike Wollmann, Ans M M van Pelt, Philipp Kaldis, Daniel M Messerschmidt
(2020) Stem Cell Reports
Journal article

Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease

Jennifer Qin Jing Zhang, Jane Burgess, Daria Stepanova, Sayanthooran Saravanabavan, Annette T Y Wong, et al.
(2020) Laboratory Investigation
Journal article

A novel function for CDK2 activity at meiotic crossover sites

Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, et al.
(2020) PLoS Biology, 18
Journal article

Discovery of a chemical probe for PRDM9

Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, et al.
(2019) Nature Communications, 10 p.1-11
Journal article

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M.F. Goh, et al.
(2019) Cellular and Molecular Life Sciences
Journal article

CDK2 kinase activity is a regulator of male germ cell fate

Priti Singh, Ravi K Patel, Nathan Palmer, Jennifer K Grenier, Darius Paduch, et al.
(2019) Development (Cambridge)
Journal article

CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I

Nathan Palmer, S Zakiah A Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, et al.
(2019) Journal of Cell Biology, 218 p.2896-2918
Journal article

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

Victor S Tapia, Michael J D Daniels, Pablo Palazón-Riquelme, Matthew Dewhurst, Nadia M Luheshi, et al.
(2019) Journal of Biological Chemistry, 294 p.8325-8335
Journal article

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Radoslaw Szmyd, Joanna Niska-Blakie, M Kasim Diril, Patrícia Renck Nunes, Konstantinos Tzelepis, et al.
(2019) Oncogene, 38 p.998-1018
Journal article

Diverse roles for CDK-associated activity during spermatogenesis

Nathan Palmer, S Zakiah A Talib, Philipp Kaldis
(2019) FEBS Letters, 593 p.2925-2949
Journal article review

Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone

Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, et al.
(2018) Journal of Biological Chemistry, 293 p.19387-19399
Journal article

Metabolic Remodeling during Liver Regeneration

Matias J Caldez, Noémi Van Hul, Hiromi W L Koh, Xing Qi Teo, Jun Jun Fan, et al.
(2018) Developmental Cell, 47 p.425-438
Journal article

Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis

Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, et al.
(2018) Cell Death and Differentiation, 25 p.1174-1188
Journal article

Modulation of Protein-Interaction States through the Cell Cycle

Lingyun Dai, Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, et al.
(2018) Cell, 173 p.1481-1494
Journal article

Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death

Quentin Marlier, Florian Jibassia, Sébastien Verteneuil, Jérôme Linden, Philipp Kaldis, et al.
(2018) Cell death discovery, 4 p.1-12
Journal article

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells

Chris Soon Heng Tan, Ka Diam Go, Xavier Bisteau, Lingyun Dai, Chern Han Yong, et al.
(2018) Science (New York, N.Y.), 359 p.1170-1177
Journal article

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

Christian Windpassinger, Juliette Piard, Carine Bonnard, Majid Alfadhel, Shuhui Lim, et al.
(2017) American Journal of Human Genetics, 101 p.391-403
Journal article

Cell size control – a mechanism for maintaining fitness and function

Teemu P. Miettinen, Matias J. Caldez, Philipp Kaldis, Mikael Björklund
(2017) BioEssays, 39
Journal article review

Cyclin-dependent kinasedependent phosphorylation of Sox2 at serine 39 regulates neurogenesis

Shuhui Lim, Akshay Bhinge, Sara Bragado Alonso, Irene Aksoy, Julieta Aprea, et al.
(2017) Molecular and Cellular Biology, 37
Journal article

Emi2 Is Essential for Mouse Spermatogenesis

Lakshmi Gopinathan, Radoslaw Szmyd, Diana Low, M. Kasim Diril, Heng Yu Chang, et al.
(2017) Cell Reports, 20 p.697-708
Journal article

Loss of cyclin-dependent kinase 2 in the pancreas links primary β-cell dysfunction to progressive depletion of β-cell mass and diabetes

So Yoon Kim, Ji Hyeon Lee, Matthew J. Merrins, Oksana Gavrilova, Xavier Bisteau, et al.
(2017) Journal of Biological Chemistry, 292 p.3841-3853
Journal article

MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice

Sanjiv Risal, Jingjing Zhang, Deepak Adhikari, Xiaoman Liu, Jingchen Shao, et al.
(2017) Cell Discovery, 3
Journal article

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation

Zhaowei Tu, Mustafa Bilal Bayazit, Hongbin Liu, Jingjing Zhang, Kiran Busayavalasa, et al.
(2017) Proceedings of the National Academy of Sciences of the United States of America, 114 p.592-597
Journal article

Cyclin A2 regulates erythrocyte morphology and numbers

Senthil Raja Jayapal, Heather Yin Kuan Ang, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, et al.
(2016) Cell Cycle, 15 p.3070-3081
Journal article

Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function

Roland G. Huber, Irina Kulemzina, Keven Ang, Alap P. Chavda, Sasikala Suranthran, et al.
(2016) Structure, 24 p.1991-1999
Journal article

Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan

Deepak Adhikari, Kiran Busayavalasa, Jingjing Zhang, Mengwen Hu, Sanjiv Risal, et al.
(2016) Cell Research, 26 p.1212-1225
Journal article

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

M. Kasim Diril, Xavier Bisteau, Mayumi Kitagawa, Matias J. Caldez, Sheena Wee, et al.
(2016) PLoS Genetics, 12 p.1-26
Journal article

Quo Vadis cell growth and division?

Philipp Kaldis
(2016) Frontiers in cell and developmental biology, 4
Journal article (comment)

The Speedy A, Cdk2, p27 triangle

Matthew R. Dewhurst, Philipp Kaldis
(2016) Cell Cycle, 15 p.489-490
Journal article (comment)

Cdk2 catalytic activity is essential for meiotic cell division in vivo

Sangeeta Chauhan, M. Kasim Diril, Joanna H.S. Lee, Xavier Bisteau, Vanessa Manoharan, et al.
(2016) Biochemical Journal, 473 p.2783-2798
Journal article

Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development

N. Palmer, P. Kaldis
(2016) Current Topics in Developmental Biology, 120 p.1-53
Book chapter

The indispensable role of cyclin-dependent kinase 1 in skeletal development

Masanori Saito, Mieradili Mulati, S. Zakiah A. Talib, Philipp Kaldis, Shu Takeda, et al.
(2016) Scientific Reports, 6
Journal article

A haploid genetic screen identifies the G₁/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity

Anne Margriet Heijink, Vincent A. Blomen, Xavier Bisteau, Fabian Degener, Felipe Yu Matsushita, et al.
(2015) Proceedings of the National Academy of Sciences of the United States of America, 112 p.15160-15165
Journal article

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, et al.
(2015) Oncotarget, 6 p.27252-27266
Journal article

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress

Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, et al.
(2015) Haematologica, 100 p.431-438
Journal article

Mastl/PP2A regulate Cdk1 in ooycte maturation

Deepak Adhikari, Kui Liu, Philipp Kaldis
(2015) Oncotarget, 6 p.18734-18735
Review

MEN1 tumorigenesis in the pituitary and pancreatic islet requires CDK4 but not Cdk2

M. P. Gillam, D. Nimbalkar, L. Sun, K. Christov, D. Ray, et al.
(2015) Oncogene, 34 p.932-938
Journal article

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

Deepak Adhikari, M. Kasim Diril, Kiran Busayavalasa, Sanjiv Risal, Shoma Nakagawa, et al.
(2014) Journal of Cell Biology, 206 p.843-853
Journal article

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

Lakshmi Gopinathan, Shawn Lu Wen Tan, V. C. Padmakumar, Vincenzo Coppola, Lino Tessarollo, et al.
(2014) Cancer Research, 74 p.3870-3879
Journal article

P57^Kip2regulates T-cell development and lymphoma

Senthil Raja Jayapal, Philipp Kaldis
(2014) Blood, 123 p.3370-3371
Journal article review

Identification of transcriptional and metabolic programs related to mammalian cell size

Teemu P. Miettinen, Heli K.J. Pessa, Matias J. Caldez, Tobias Fuhrer, M. Kasim Diril, et al.
(2014) Current Biology, 24 p.598-608
Journal article

The complex relationship between liver cancer and the cell cycle : A story of multiple regulations

Xavier Bisteau, Matias J. Caldez, Philipp Kaldis
(2014) Cancers, 6 p.79-111
Journal article review

p27 is regulated independently of Skp2 in the absence of Cdk2

Shuhei Kotoshiba, Lakshmi Gopinathan, Elisabeth Pfeiffenberger, Anisa Rahim, Leah A. Vardy, et al.
(2014) Biochimica et Biophysica Acta - Molecular Cell Research, 1843 p.436-445
Journal article

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

Wei Theng Poh, Gaganmeet Singh Chadha, Peter J. Gillespie, Philipp Kaldis, J. Julian Blow
(2014) Open biology, 4
Journal article

Spy1/SpeedyA accelerates neuroblastoma

Xavier Bisteau, Philipp Kaldis
(2014) Oncotarget, 5 p.6554-6555
Journal article review

Cyclin E1 regulates hematopoietic stem cell quiescence

Senthil Raja Jayapal, Philipp Kaldis
(2013) Cell Cycle, 12 p.3588-3588
Journal article (comment)

Cdks, cyclins and CKIs : Roles beyond cell cycle regulation

Shuhui Lim, Philipp Kaldis
(2013) Development (Cambridge), 140 p.3079-3093
Journal article review

Evolution of the Cdk-activator Speedy/RINGO in vertebrates

Sangeeta Chauhan, Xinde Zheng, Yue Ying Tan, Boon Hui Tay, Shuhui Lim, et al.
(2012) Cellular and Molecular Life Sciences, 69 p.3835-3850
Journal article

Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells

Shuhui Lim, Philipp Kaldis
(2012) Stem Cells, 30 p.1509-1520
Journal article

Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes

Deepak Adhikari, Wenjing Zheng, Yan Shen, Nagaraju Gorre, Yao Ning, et al.
(2012) Human Molecular Genetics, 21 p.2476-2484
Journal article

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

M. Kasim Diril, Chandrahas Koumar Ratnacaram, V. C. Padmakumar, Tiehua Du, Martin Wasser, et al.
(2012) Proceedings of the National Academy of Sciences of the United States of America, 109 p.3826-3831
Journal article

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

Wen Cai Zhang, Shyh Chang Ng, He Yang, Amit Rai, Shivshankar Umashankar, et al.
(2012) Cell, 148 p.259-272
Journal article

When cell cycle meets development

Philipp Kaldis, Helena E. Richardson
(2012) Development: For advances in developmental biology and stem cells, 139 p.225-230
Journal article review

Established and novel Cdk/Cyclin complexes regulating the cell cycle and development

Lakshmi Gopinathan, Chandrahas Koumar Ratnacaram, Philipp Kaldis
(2011) Results and Problems in Cell Differentiation, 53 p.365-389
Book chapter

Cell cycle transitions and Cdk inhibition in melanoma therapy : Cyclin' through the options

Michael B. Mann, Philipp Kaldis
(2011) Cell Cycle, 10
Journal article (comment)

Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis

Dipankar Ray, Yasuhisa Terao, Konstantin Christov, Philipp Kaldis, Hiroaki Kiyokawa
(2011) Neoplasia, 13 p.439-444
Journal article

Enforcing the Greatwall in Mitosis

David M. Virshup, Philipp Kaldis
(2010) Science, 330 p.1638-1639
Journal article review

Down-regulation of Myc is essential for terminal erythroid maturation

Senthil Raja Jayapal, Kian Leong Lee, Peng Ji, Philipp Kaldis, Bing Lim, et al.
(2010) Journal of Biological Chemistry, 285 p.40252-40265
Journal article

Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53

C. F. Cheok, N. Kua, P. Kaldis, D. P. Lane
(2010) Cell Death and Differentiation, 17 p.1486-1500
Journal article

Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells

Arsene M. Adon, Xiangbin Zeng, Mary K. Harrison, Stacy Sannem, Hiroaki Kiyokawa, et al.
(2010) Molecular and Cellular Biology, 30 p.694-710
Journal article

Wnt Signaling in Mitosis

Philipp Kaldis, Michele Pagano
(2009) Developmental Cell, 17 p.749-750
Journal article review

Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo

Eric A. Hanse, Christopher J. Nelsen, Melissa M. Goggin, Chelsea K. Anttila, Lisa K. Mullany, et al.
(2009) Cell Cycle, 8 p.2802-2809
Journal article

Mammalian cell-cycle regulation : Several cdks, numerous cyclins and diverse compensatory mechanisms

A. Satyanarayana, P. Kaldis
(2009) Oncogene, 28 p.2925-2939
Journal article review

Genetic mouse models to investigate cell cycle regulation

Weimin Li, Shuhei Kotoshiba, Philipp Kaldis
(2009) Transgenic Research, 18 p.491-498
Journal article review

A dual role of Cdk2 in DNA damage response

Ande Satyanarayana, Philipp Kaldis
(2009) Cell Division, 4
Journal article review

Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53

V. C. Padmakumar, Eiman Aleem, Cyril Berthet, Mary Beth Hilton, Philipp Kaldis
(2009) Molecular and Cellular Biology, 29 p.2582-2593
Journal article

Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G₁/S transition

Weimin Li, Shuhei Kotoshiba, Cyril Berthet, Mary Beth Hilton, Philipp Kaldis
(2009) Proceedings of the National Academy of Sciences of the United States of America, 106 p.486-491
Journal article

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

Ande Satyanarayana, Cyril Berthet, Javier Lopez-Molina, Vincenzo Coppola, Lino Tessarollo, et al.
(2008) Development: For advances in developmental biology and stem cells, 135 p.3389-3400
Journal article

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Subha Philip, Srividya Swaminathan, Sergey G. Kuznetsov, Sreenivas Kanugula, Kajal Biswas, et al.
(2008) Cancer Research, 68 p.9973-9981
Journal article

Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury

David A. Liem, Peng Zhao, Ekaterini Angelis, Shing S. Chan, Jun Zhang, et al.
(2008) Journal of Molecular and Cellular Cardiology, 45 p.610-616
Journal article

The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation

Shashwati Basak, Suzanne B.R. Jacobs, Adam J. Krieg, Navneeta Pathak, Qi Zeng, et al.
(2008) Molecular Cell, 30 p.303-314
Journal article

p21 inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint

Ande Satyanarayana, Mary Beth Hilton, Philipp Kaldis
(2008) Molecular Biology of the Cell, 19 p.65-77
Journal article

Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

Beata Jablonska, Adan Aguirre, Renaud Vandenbosch, Shibeshih Belachew, Cyril Berthet, et al.
(2007) Journal of Cell Biology, 179 p.1231-1245
Journal article

CDK2 is dispensable for adult hippocampal neurogenesis

Renaud Vandenbosch, Laurence Borgs, Pierre Beukelaers, Agnès Foidart, Laurent Nguyen, et al.
(2007) Cell Cycle, 6 p.3065-3069
Journal article

p27^kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice

Singareddy Rajareddy, Pradeep Reddy, Chun Du, Lian Liu, Krishna Jagarlamudi, et al.
(2007) Molecular Endocrinology, 21 p.2189-2202
Journal article

Cell-specific responses to loss of cyclin-dependent kinases

C. Berthet, P. Kaldis
(2007) Oncogene, 26 p.4469-4477
Journal article review

Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2

Cyril Berthet, Maria Cecilia Rodriguez-Galan, Deborah L. Hodge, John Gooya, Véronique Pascal, et al.
(2007) Molecular and Cellular Biology, 27 p.5079-5089
Journal article

Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest

Keith Mikule, Benedicte Delaval, Philipp Kaldis, Agata Jurcyzk, Polla Hergert, et al.
(2007) Nature Cell Biology, 9 p.160-170
Journal article

Another piece of the p27Kip1 puzzle

Philipp Kaldis
(2007) Cell, 128 p.241-244
Journal article review

Kinase-independent function of Cyclin E

Yan Geng, Young Mi Lee, Markus Welcker, Jherek Swanger, Agnieszka Zagozdzon, et al.
(2007) Molecular Cell, 25 p.127-139
Journal article

Mouse models of cell cycle regulators : New paradigms

Eiman Aleem, Philipp Kaldis
(2006) Results and Problems in Cell Differentiation, 42 p.271-328
Book chapter

PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes

Audrey J. Robinson-White, Wolfgang W. Leitner, Eiman Aleem, Philipp Kaldis, Ioannis Bossis, et al.
(2006) Cancer Research, 66 p.10603-10612
Journal article

Identification of Yin-Yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase

Zheng Fu, Katherine A. Larson, Raghu K. Chitta, Sirlester A. Parker, Benjamin E. Turk, et al.
(2006) Molecular and Cellular Biology, 26 p.8639-8654
Journal article

Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2

Peter M. Price, Fang Yu, Philipp Kaldis, Eiman Aleem, Grazyna Nowak, et al.
(2006) Journal of the American Society of Nephrology, 17 p.2434-2442
Journal article

CDK2 is required by MYC to induce apoptosis

Debabrita Deb-Basu, Eiman Aleem, Philipp Kaldis, Dean W. Felsher
(2006) Cell Cycle, 5 p.1342-1347
Journal article

Cdk2 and Cdk4 cooperatively control the expression of Cdc2

Cyril Berthet, Philipp Kaldis
(2006) Cell Division, 1
Journal article review

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

Cyril Berthet, Kimberly D. Klarmann, Mary Beth Hilton, Hyung Chan Suh, Jonathan R. Keller, et al.
(2006) Developmental Cell, 10 p.563-573
Journal article

Cell Division, a new open access online forum for and from the cell cycle community

Philipp Kaldis, Michele Pagano
(2006) Cell Division, 1
Journal article (comment)

IL-7 promotes T cell proliferation through destabilization of p27^Kip1

Qing Li Wen, Qiong Jiang, Eiman Aleem, Philipp Kaldis, Annette R. Khaled, et al.
(2006) Journal of Experimental Medicine, 203 p.573-582
Journal article

p205, A potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation

Benyam Asefa, Jonathan M. Dermott, Philipp Kaldis, Karen Stefanisko, David J. Garfinkel, et al.
(2006) FEBS Letters, 580 p.1205-1214
Journal article

Biochemical characterization of Cdk2-Speedy/Ringo A2

Aiyang Cheng, Shannon Gerry, Philipp Kaldis, Mark J. Solomon
(2005) BMC Biochemistry, 6
Journal article

Cdc2-cyclin E complexes regulate the G1/S phase transition

Eiman Aleem, Hiroaki Kiyokawa, Philipp Kaldis
(2005) Nature Cell Biology, 7 p.831-836
Journal article

Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint

Stefano Campaner, Philipp Kaldis, Shai Izraeli, Ilan R. Kirsch
(2005) Molecular and Cellular Biology, 25 p.6660-6672
Journal article

Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase

Zheng Fu, Melanie J. Schroeder, Jeffrey Shabanowitz, Philipp Kaldis, Kasumi Togawa, et al.
(2005) Molecular and Cellular Biology, 25 p.6047-6064
Journal article

The N-terminal peptide of the Kaposi's sarcoma-associated herpesvirus (KSHV)-cyclin determines substrate specificity

Philipp Kaldis
(2005) Journal of Biological Chemistry, 280 p.11165-11174
Journal article

Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter

Makoto Sugaya, Takahiro Watanabe, Aparche Yang, Matthew F. Starost, Hisataka Kobayashi, et al.
(2005) Blood, 105 p.2356-2363
Journal article

Cell cycle sibling rivalry Cdc2 vs. Cdk2

Philipp Kaldis, Eiman Aleem
(2005) Cell Cycle, 4 p.1491-1494
Journal article review

Cell cycle-dependent phosphorylation of C/EBPβ mediates oncogenic cooperativity between C/EBPβ and H-Ras^V12

Jon D. Shuman, Thomas Sebastian, Philipp Kaldis, Terry D. Copeland, Songyun Zhu, et al.
(2004) Molecular and Cellular Biology, 24 p.7380-7391
Journal article

Cdk2 as a master of S phase entry : Fact or fake?

Eiman Aleem, Cyril Berthet, Philipp Kaldis
(2004) Cell Cycle, 3 p.34-36
Journal article review

Cdk2 knockout mice are viable

Cyril Berthet, Eiman Aleem, Vincenzo Coppola, Lino Tessarollo, Philipp Kaldis
(2003) Current Biology, 13 p.1775-1785
Journal article

CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion

M. Schaber, A. Lindgren, K. Schindler, D. Bungard, P. Kaldis, et al.
(2002) Molecular and Cellular Biology, 22 p.57-68
Journal article

CAK-independent activation of CDK6 by a viral cyclin

P. Kaldis, P. M. Ojala, L. Tong, T. P. Mäkelä, M. J. Solomon
(2001) Molecular Biology of the Cell, 12 p.3987-3999
Journal article

Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Cα and β2 isoforms

Aiyang Cheng, Philipp Kaldis, Mark J. Solomon
(2000) Journal of Biological Chemistry, 275 p.34744-34749
Journal article

Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast

Deborah A. Enke, Philipp Kaldis, Mark J. Solomon
(2000) Journal of Biological Chemistry, 275 p.33267-33271
Journal article

The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine

P. Kaldis, A. Cheng, M. J. Solomon
(2000) Journal of Biological Chemistry, 275 p.32578-32584
Journal article

Analysis of CAK activities from human cells

Philipp Kaldis, Mark J. Solomon
(2000) European Journal of Biochemistry, 267 p.4213-4221
Journal article

Activating phosphorylation of the Saccharomyces cerevisiae cyclin- dependent kinase, Cdc28p, precedes cyclin binding

Karen E. Ross, Philipp Kaldis, Mark J. Solomon
(2000) Molecular Biology of the Cell, 11 p.1597-1609
Journal article

Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

Hikaru Nagahara, Sergei A. Ezhevsky, Adamina M. Vocero-Akbani, Philipp Kaldis, Mark J. Solomon, et al.
(1999) Proceedings of the National Academy of Sciences of the United States of America, 96 p.14961-14966
Journal article

Philipp Kaldis

Publications