
Philipp Kaldis
Principal investigator

Publications
Displaying of publications. Sorted by year, then title.
Proof-of-concept method to study uncharacterized methyltransferases using PRDM15
Li-Na Zhao, Ernesto Guccione, Philipp Kaldis
(2023) International Journal of Molecular Sciences, 24 p.1-12
Journal articleLiver-derived metabolites as signaling molecules in fatty liver disease
Umur Keles, Jin Rong Ow, Katharina Barbara Kuentzel, Li Na Zhao, Philipp Kaldis
(2023) Cellular and Molecular Life Sciences, 80 p.1-14
Journal article reviewThe catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)
Li Na Zhao, Philipp Kaldis
(2022) PLoS Computational Biology, 18
Journal articleHistidine protonation states are key in the LigI catalytic reaction mechanism
Lina Zhao, Dibyendu Mondal, Weifeng Li, Yuguang Mu, Philipp Kaldis
(2022) Proteins, 90 p.123-130
Journal articleEditorial : Editor's Pick 2021: Highlights in Cell Growth and Division
Philipp Kaldis
(2022) Frontiers in cell and developmental biology, 10 p.1-1
Journal article (comment)Pairing structural reconstruction with catalytic competence to evaluate the mechanisms of key enzymes in the folate-mediated one-carbon pathway
Li Na Zhao, Philipp Kaldis
(2022) The FEBS Journal
Journal article reviewPathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
Jose Marcos Sanches, Li Na Zhao, Albert Salehi, Claes B Wollheim, Philipp Kaldis
(2021) The FEBS Journal
Journal article reviewTherapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
Li Na Zhao, Mikael Björklund, Matias J Caldez, Jie Zheng, Philipp Kaldis
(2021) Oncogene
Journal article reviewProtective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis
Jianliang Xu, P Jaya Kausalya, Noémi Van Hul, Matias J Caldez, Shiyi Xu, et al.
(2021) Gastroenterology, 160 p.2103-2118
Journal articleRemodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
Jin Rong Ow, Matias J Cadez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, et al.
(2020) eLife, 9
Journal articlePRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, et al.
(2020) Nature Communications, 11
Journal articleLoss of hepatocyte cell division leads to liver inflammation and fibrosis
Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, et al.
(2020) PLoS Genetics, 16 p.1009084-1009084
Journal articleLess-well known functions of cyclin/CDK complexes
Nathan Palmer, Philipp Kaldis
(2020) Seminars in Cell & Developmental Biology, 107 p.54-62
Journal article reviewCyclin-dependent kinase 1 is essential for muscle regeneration and overload muscle fiber hypertrophy
Yutaka Kobayashi, Tomoyuki Tanaka, Mieradilli Mulati, Hiroki Ochi, Shingo Sato, et al.
(2020) Frontiers in cell and developmental biology, 8
Journal articleMetaboKit : a comprehensive data extraction tool for untargeted metabolomics
Pradeep Narayanaswamy, Guoshou Teo, Jin Rong Ow, Adam Lau, Philipp Kaldis, et al.
(2020) Molecular omics, 16 p.436-447
Journal articleThe Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis
Xavier Bisteau, Joann Lee, Vinayaka Srinivas, Joanna H.S. Lee, Joanna Niska-Blakie, et al.
(2020) Oncogene
Journal articleCascading proton transfers are a hallmark of the catalytic mechanism of SAM-dependent methyltransferases
Li Na Zhao, Philipp Kaldis
(2020) FEBS Letters, 594 p.2128-2139
Journal articleCell cycle regulation in NAFLD: when imbalanced metabolism limits cell division : when imbalanced metabolism limits cell division
Matias J Caldez, Mikael Bjorklund, Philipp Kaldis
(2020) Hepatology international, 14 p.463-474
Journal article reviewInfertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia
Joel H L Tan, Heike Wollmann, Ans M M van Pelt, Philipp Kaldis, Daniel M Messerschmidt
(2020) Stem Cell Reports, 14 p.818-827
Journal articleRole of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease
Jennifer Qin Jing Zhang, Jane Burgess, Daria Stepanova, Sayanthooran Saravanabavan, Annette T Y Wong, et al.
(2020) Laboratory Investigation, 100 p.696-711
Journal articleA novel function for CDK2 activity at meiotic crossover sites
Nathan Palmer, S Zakiah A Talib, Priti Singh, Christine M F Goh, Kui Liu, et al.
(2020) PLoS Biology, 18
Journal articleDiscovery of a chemical probe for PRDM9
Abdellah Allali-Hassani, Magdalena M Szewczyk, Danton Ivanochko, Shawna L Organ, Jabez Bok, et al.
(2019) Nature Communications, 10 p.1-11
Journal articleKnockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
Joanna Niska-Blakie, Lakshmi Gopinathan, Kia Ngee Low, Yang Lay Kien, Christine M.F. Goh, et al.
(2019) Cellular and Molecular Life Sciences
Journal articleCDK2 kinase activity is a regulator of male germ cell fate
Priti Singh, Ravi K Patel, Nathan Palmer, Jennifer K Grenier, Darius Paduch, et al.
(2019) Development (Cambridge)
Journal articleCDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I
Nathan Palmer, S Zakiah A Talib, Chandrahas Koumar Ratnacaram, Diana Low, Xavier Bisteau, et al.
(2019) Journal of Cell Biology, 218 p.2896-2918
Journal articleThe three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes
Victor S Tapia, Michael J D Daniels, Pablo Palazón-Riquelme, Matthew Dewhurst, Nadia M Luheshi, et al.
(2019) Journal of Biological Chemistry, 294 p.8325-8335
Journal articlePremature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
Radoslaw Szmyd, Joanna Niska-Blakie, M Kasim Diril, Patrícia Renck Nunes, Konstantinos Tzelepis, et al.
(2019) Oncogene, 38 p.998-1018
Journal articleDiverse roles for CDK-associated activity during spermatogenesis
Nathan Palmer, S Zakiah A Talib, Philipp Kaldis
(2019) FEBS Letters, 593 p.2925-2949
Journal article reviewLoss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone
Akira Takahashi, Mieradili Mulati, Masanori Saito, Hoashi Numata, Yutaka Kobayashi, et al.
(2018) Journal of Biological Chemistry, 293 p.19387-19399
Journal articleMetabolic Remodeling during Liver Regeneration
Matias J Caldez, Noémi Van Hul, Hiromi W L Koh, Xing Qi Teo, Jun Jun Fan, et al.
(2018) Developmental Cell, 47 p.425-438
Journal articleDual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis
Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, et al.
(2018) Cell Death and Differentiation, 25 p.1174-1188
Journal articleModulation of Protein-Interaction States through the Cell Cycle
Lingyun Dai, Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, et al.
(2018) Cell, 173 p.1481-1494
Journal articleGenetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death
Quentin Marlier, Florian Jibassia, Sébastien Verteneuil, Jérôme Linden, Philipp Kaldis, et al.
(2018) Cell death discovery, 4 p.1-12
Journal articleThermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells
Chris Soon Heng Tan, Ka Diam Go, Xavier Bisteau, Lingyun Dai, Chern Han Yong, et al.
(2018) Science (New York, N.Y.), 359 p.1170-1177
Journal articleCDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays
Christian Windpassinger, Juliette Piard, Carine Bonnard, Majid Alfadhel, Shuhui Lim, et al.
(2017) American Journal of Human Genetics, 101 p.391-403
Journal articleCell size control – a mechanism for maintaining fitness and function
Teemu P. Miettinen, Matias J. Caldez, Philipp Kaldis, Mikael Björklund
(2017) BioEssays, 39
Journal article reviewCyclin-dependent kinasedependent phosphorylation of Sox2 at serine 39 regulates neurogenesis
Shuhui Lim, Akshay Bhinge, Sara Bragado Alonso, Irene Aksoy, Julieta Aprea, et al.
(2017) Molecular and Cellular Biology, 37
Journal articleEmi2 Is Essential for Mouse Spermatogenesis
Lakshmi Gopinathan, Radoslaw Szmyd, Diana Low, M. Kasim Diril, Heng Yu Chang, et al.
(2017) Cell Reports, 20 p.697-708
Journal articleLoss of cyclin-dependent kinase 2 in the pancreas links primary β-cell dysfunction to progressive depletion of β-cell mass and diabetes
So Yoon Kim, Ji Hyeon Lee, Matthew J. Merrins, Oksana Gavrilova, Xavier Bisteau, et al.
(2017) Journal of Biological Chemistry, 292 p.3841-3853
Journal articleMASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice
Sanjiv Risal, Jingjing Zhang, Deepak Adhikari, Xiaoman Liu, Jingchen Shao, et al.
(2017) Cell Discovery, 3
Journal articleSpeedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation
Zhaowei Tu, Mustafa Bilal Bayazit, Hongbin Liu, Jingjing Zhang, Kiran Busayavalasa, et al.
(2017) Proceedings of the National Academy of Sciences of the United States of America, 114 p.592-597
Journal articleCyclin A2 regulates erythrocyte morphology and numbers
Senthil Raja Jayapal, Heather Yin Kuan Ang, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, et al.
(2016) Cell Cycle, 15 p.3070-3081
Journal articleImpairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function
Roland G. Huber, Irina Kulemzina, Keven Ang, Alap P. Chavda, Sasikala Suranthran, et al.
(2016) Structure, 24 p.1991-1999
Journal articleInhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan
Deepak Adhikari, Kiran Busayavalasa, Jingjing Zhang, Mengwen Hu, Sanjiv Risal, et al.
(2016) Cell Research, 26 p.1212-1225
Journal articleLoss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint
M. Kasim Diril, Xavier Bisteau, Mayumi Kitagawa, Matias J. Caldez, Sheena Wee, et al.
(2016) PLoS Genetics, 12 p.1-26
Journal articleQuo Vadis cell growth and division?
Philipp Kaldis
(2016) Frontiers in cell and developmental biology, 4
Journal article (comment)The Speedy A, Cdk2, p27 triangle
Matthew R. Dewhurst, Philipp Kaldis
(2016) Cell Cycle, 15 p.489-490
Journal article (comment)Cdk2 catalytic activity is essential for meiotic cell division in vivo
Sangeeta Chauhan, M. Kasim Diril, Joanna H.S. Lee, Xavier Bisteau, Vanessa Manoharan, et al.
(2016) Biochemical Journal, 473 p.2783-2798
Journal articleRegulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development
N. Palmer, P. Kaldis
(2016) Current Topics in Developmental Biology, 120 p.1-53
Book chapterThe indispensable role of cyclin-dependent kinase 1 in skeletal development
Masanori Saito, Mieradili Mulati, S. Zakiah A. Talib, Philipp Kaldis, Shu Takeda, et al.
(2016) Scientific Reports, 6
Journal articleA haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity
Anne Margriet Heijink, Vincent A. Blomen, Xavier Bisteau, Fabian Degener, Felipe Yu Matsushita, et al.
(2015) Proceedings of the National Academy of Sciences of the United States of America, 112 p.15160-15165
Journal articleTLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, et al.
(2015) Oncotarget, 6 p.27252-27266
Journal articleHematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress
Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, et al.
(2015) Haematologica, 100 p.431-438
Journal articleMastl/PP2A regulate Cdk1 in ooycte maturation
Deepak Adhikari, Kui Liu, Philipp Kaldis
(2015) Oncotarget, 6 p.18734-18735
ReviewMEN1 tumorigenesis in the pituitary and pancreatic islet requires CDK4 but not Cdk2
M. P. Gillam, D. Nimbalkar, L. Sun, K. Christov, D. Ray, et al.
(2015) Oncogene, 34 p.932-938
Journal articleMastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II
Deepak Adhikari, M. Kasim Diril, Kiran Busayavalasa, Sanjiv Risal, Shoma Nakagawa, et al.
(2014) Journal of Cell Biology, 206 p.843-853
Journal articleLoss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis
Lakshmi Gopinathan, Shawn Lu Wen Tan, V. C. Padmakumar, Vincenzo Coppola, Lino Tessarollo, et al.
(2014) Cancer Research, 74 p.3870-3879
Journal articleP57Kip2regulates T-cell development and lymphoma
Senthil Raja Jayapal, Philipp Kaldis
(2014) Blood, 123 p.3370-3371
Journal article reviewIdentification of transcriptional and metabolic programs related to mammalian cell size
Teemu P. Miettinen, Heli K.J. Pessa, Matias J. Caldez, Tobias Fuhrer, M. Kasim Diril, et al.
(2014) Current Biology, 24 p.598-608
Journal articleThe complex relationship between liver cancer and the cell cycle : A story of multiple regulations
Xavier Bisteau, Matias J. Caldez, Philipp Kaldis
(2014) Cancers, 6 p.79-111
Journal article reviewp27 is regulated independently of Skp2 in the absence of Cdk2
Shuhei Kotoshiba, Lakshmi Gopinathan, Elisabeth Pfeiffenberger, Anisa Rahim, Leah A. Vardy, et al.
(2014) Biochimica et Biophysica Acta - Molecular Cell Research, 1843 p.436-445
Journal articleXenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1
Wei Theng Poh, Gaganmeet Singh Chadha, Peter J. Gillespie, Philipp Kaldis, J. Julian Blow
(2014) Open biology, 4
Journal articleSpy1/SpeedyA accelerates neuroblastoma
Xavier Bisteau, Philipp Kaldis
(2014) Oncotarget, 5 p.6554-6555
Journal article reviewCyclin E1 regulates hematopoietic stem cell quiescence
Senthil Raja Jayapal, Philipp Kaldis
(2013) Cell Cycle, 12 p.3588-3588
Journal article (comment)Cdks, cyclins and CKIs : Roles beyond cell cycle regulation
Shuhui Lim, Philipp Kaldis
(2013) Development (Cambridge), 140 p.3079-3093
Journal article reviewEvolution of the Cdk-activator Speedy/RINGO in vertebrates
Sangeeta Chauhan, Xinde Zheng, Yue Ying Tan, Boon Hui Tay, Shuhui Lim, et al.
(2012) Cellular and Molecular Life Sciences, 69 p.3835-3850
Journal articleLoss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells
Shuhui Lim, Philipp Kaldis
(2012) Stem Cells, 30 p.1509-1520
Journal articleCdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes
Deepak Adhikari, Wenjing Zheng, Yan Shen, Nagaraju Gorre, Yao Ning, et al.
(2012) Human Molecular Genetics, 21 p.2476-2484
Journal articleCyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
M. Kasim Diril, Chandrahas Koumar Ratnacaram, V. C. Padmakumar, Tiehua Du, Martin Wasser, et al.
(2012) Proceedings of the National Academy of Sciences of the United States of America, 109 p.3826-3831
Journal articleGlycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
Wen Cai Zhang, Shyh Chang Ng, He Yang, Amit Rai, Shivshankar Umashankar, et al.
(2012) Cell, 148 p.259-272
Journal articleWhen cell cycle meets development
Philipp Kaldis, Helena E. Richardson
(2012) Development: For advances in developmental biology and stem cells, 139 p.225-230
Journal article reviewEstablished and novel Cdk/Cyclin complexes regulating the cell cycle and development
Lakshmi Gopinathan, Chandrahas Koumar Ratnacaram, Philipp Kaldis
(2011) Results and Problems in Cell Differentiation, 53 p.365-389
Book chapterCell cycle transitions and Cdk inhibition in melanoma therapy : Cyclin' through the options
Michael B. Mann, Philipp Kaldis
(2011) Cell Cycle, 10
Journal article (comment)Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis
Dipankar Ray, Yasuhisa Terao, Konstantin Christov, Philipp Kaldis, Hiroaki Kiyokawa
(2011) Neoplasia, 13 p.439-444
Journal articleEnforcing the Greatwall in Mitosis
David M. Virshup, Philipp Kaldis
(2010) Science, 330 p.1638-1639
Journal article reviewDown-regulation of Myc is essential for terminal erythroid maturation
Senthil Raja Jayapal, Kian Leong Lee, Peng Ji, Philipp Kaldis, Bing Lim, et al.
(2010) Journal of Biological Chemistry, 285 p.40252-40265
Journal articleCombination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
C. F. Cheok, N. Kua, P. Kaldis, D. P. Lane
(2010) Cell Death and Differentiation, 17 p.1486-1500
Journal articleCdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells
Arsene M. Adon, Xiangbin Zeng, Mary K. Harrison, Stacy Sannem, Hiroaki Kiyokawa, et al.
(2010) Molecular and Cellular Biology, 30 p.694-710
Journal articleWnt Signaling in Mitosis
Philipp Kaldis, Michele Pagano
(2009) Developmental Cell, 17 p.749-750
Journal article reviewCdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo
Eric A. Hanse, Christopher J. Nelsen, Melissa M. Goggin, Chelsea K. Anttila, Lisa K. Mullany, et al.
(2009) Cell Cycle, 8 p.2802-2809
Journal articleMammalian cell-cycle regulation : Several cdks, numerous cyclins and diverse compensatory mechanisms
A. Satyanarayana, P. Kaldis
(2009) Oncogene, 28 p.2925-2939
Journal article reviewGenetic mouse models to investigate cell cycle regulation
Weimin Li, Shuhei Kotoshiba, Philipp Kaldis
(2009) Transgenic Research, 18 p.491-498
Journal article reviewA dual role of Cdk2 in DNA damage response
Ande Satyanarayana, Philipp Kaldis
(2009) Cell Division, 4
Journal article reviewCdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53
V. C. Padmakumar, Eiman Aleem, Cyril Berthet, Mary Beth Hilton, Philipp Kaldis
(2009) Molecular and Cellular Biology, 29 p.2582-2593
Journal articleRb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition
Weimin Li, Shuhei Kotoshiba, Cyril Berthet, Mary Beth Hilton, Philipp Kaldis
(2009) Proceedings of the National Academy of Sciences of the United States of America, 106 p.486-491
Journal articleGenetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2
Ande Satyanarayana, Cyril Berthet, Javier Lopez-Molina, Vincenzo Coppola, Lino Tessarollo, et al.
(2008) Development: For advances in developmental biology and stem cells, 135 p.3389-3400
Journal articleDegradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications
Subha Philip, Srividya Swaminathan, Sergey G. Kuznetsov, Sreenivas Kanugula, Kajal Biswas, et al.
(2008) Cancer Research, 68 p.9973-9981
Journal articleCyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury
David A. Liem, Peng Zhao, Ekaterini Angelis, Shing S. Chan, Jun Zhang, et al.
(2008) Journal of Molecular and Cellular Cardiology, 45 p.610-616
Journal articleThe metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation
Shashwati Basak, Suzanne B.R. Jacobs, Adam J. Krieg, Navneeta Pathak, Qi Zeng, et al.
(2008) Molecular Cell, 30 p.303-314
Journal articlep21 inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint
Ande Satyanarayana, Mary Beth Hilton, Philipp Kaldis
(2008) Molecular Biology of the Cell, 19 p.65-77
Journal articleCdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone
Beata Jablonska, Adan Aguirre, Renaud Vandenbosch, Shibeshih Belachew, Cyril Berthet, et al.
(2007) Journal of Cell Biology, 179 p.1231-1245
Journal articleCDK2 is dispensable for adult hippocampal neurogenesis
Renaud Vandenbosch, Laurence Borgs, Pierre Beukelaers, Agnès Foidart, Laurent Nguyen, et al.
(2007) Cell Cycle, 6 p.3065-3069
Journal articlep27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice
Singareddy Rajareddy, Pradeep Reddy, Chun Du, Lian Liu, Krishna Jagarlamudi, et al.
(2007) Molecular Endocrinology, 21 p.2189-2202
Journal articleCell-specific responses to loss of cyclin-dependent kinases
C. Berthet, P. Kaldis
(2007) Oncogene, 26 p.4469-4477
Journal article reviewHematopoiesis and thymic apoptosis are not affected by the loss of Cdk2
Cyril Berthet, Maria Cecilia Rodriguez-Galan, Deborah L. Hodge, John Gooya, Véronique Pascal, et al.
(2007) Molecular and Cellular Biology, 27 p.5079-5089
Journal articleLoss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest
Keith Mikule, Benedicte Delaval, Philipp Kaldis, Agata Jurcyzk, Polla Hergert, et al.
(2007) Nature Cell Biology, 9 p.160-170
Journal articleAnother piece of the p27Kip1 puzzle
Philipp Kaldis
(2007) Cell, 128 p.241-244
Journal article reviewKinase-independent function of Cyclin E
Yan Geng, Young Mi Lee, Markus Welcker, Jherek Swanger, Agnieszka Zagozdzon, et al.
(2007) Molecular Cell, 25 p.127-139
Journal articleMouse models of cell cycle regulators : New paradigms
Eiman Aleem, Philipp Kaldis
(2006) Results and Problems in Cell Differentiation, 42 p.271-328
Book chapterPRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes
Audrey J. Robinson-White, Wolfgang W. Leitner, Eiman Aleem, Philipp Kaldis, Ioannis Bossis, et al.
(2006) Cancer Research, 66 p.10603-10612
Journal articleIdentification of Yin-Yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase
Zheng Fu, Katherine A. Larson, Raghu K. Chitta, Sirlester A. Parker, Benjamin E. Turk, et al.
(2006) Molecular and Cellular Biology, 26 p.8639-8654
Journal articleDependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
Peter M. Price, Fang Yu, Philipp Kaldis, Eiman Aleem, Grazyna Nowak, et al.
(2006) Journal of the American Society of Nephrology, 17 p.2434-2442
Journal articleCDK2 is required by MYC to induce apoptosis
Debabrita Deb-Basu, Eiman Aleem, Philipp Kaldis, Dean W. Felsher
(2006) Cell Cycle, 5 p.1342-1347
Journal articleCdk2 and Cdk4 cooperatively control the expression of Cdc2
Cyril Berthet, Philipp Kaldis
(2006) Cell Division, 1
Journal article reviewCombined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
Cyril Berthet, Kimberly D. Klarmann, Mary Beth Hilton, Hyung Chan Suh, Jonathan R. Keller, et al.
(2006) Developmental Cell, 10 p.563-573
Journal articleCell Division, a new open access online forum for and from the cell cycle community
Philipp Kaldis, Michele Pagano
(2006) Cell Division, 1
Journal article (comment)IL-7 promotes T cell proliferation through destabilization of p27Kip1
Qing Li Wen, Qiong Jiang, Eiman Aleem, Philipp Kaldis, Annette R. Khaled, et al.
(2006) Journal of Experimental Medicine, 203 p.573-582
Journal articlep205, A potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation
Benyam Asefa, Jonathan M. Dermott, Philipp Kaldis, Karen Stefanisko, David J. Garfinkel, et al.
(2006) FEBS Letters, 580 p.1205-1214
Journal articleBiochemical characterization of Cdk2-Speedy/Ringo A2
Aiyang Cheng, Shannon Gerry, Philipp Kaldis, Mark J. Solomon
(2005) BMC Biochemistry, 6
Journal articleCdc2-cyclin E complexes regulate the G1/S phase transition
Eiman Aleem, Hiroaki Kiyokawa, Philipp Kaldis
(2005) Nature Cell Biology, 7 p.831-836
Journal articleSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint
Stefano Campaner, Philipp Kaldis, Shai Izraeli, Ilan R. Kirsch
(2005) Molecular and Cellular Biology, 25 p.6660-6672
Journal articleActivation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase
Zheng Fu, Melanie J. Schroeder, Jeffrey Shabanowitz, Philipp Kaldis, Kasumi Togawa, et al.
(2005) Molecular and Cellular Biology, 25 p.6047-6064
Journal articleThe N-terminal peptide of the Kaposi's sarcoma-associated herpesvirus (KSHV)-cyclin determines substrate specificity
Philipp Kaldis
(2005) Journal of Biological Chemistry, 280 p.11165-11174
Journal articleLymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter
Makoto Sugaya, Takahiro Watanabe, Aparche Yang, Matthew F. Starost, Hisataka Kobayashi, et al.
(2005) Blood, 105 p.2356-2363
Journal articleCell cycle sibling rivalry Cdc2 vs. Cdk2
Philipp Kaldis, Eiman Aleem
(2005) Cell Cycle, 4 p.1491-1494
Journal article reviewCell cycle-dependent phosphorylation of C/EBPβ mediates oncogenic cooperativity between C/EBPβ and H-RasV12
Jon D. Shuman, Thomas Sebastian, Philipp Kaldis, Terry D. Copeland, Songyun Zhu, et al.
(2004) Molecular and Cellular Biology, 24 p.7380-7391
Journal articleCdk2 as a master of S phase entry : Fact or fake?
Eiman Aleem, Cyril Berthet, Philipp Kaldis
(2004) Cell Cycle, 3 p.34-36
Journal article reviewCdk2 knockout mice are viable
Cyril Berthet, Eiman Aleem, Vincenzo Coppola, Lino Tessarollo, Philipp Kaldis
(2003) Current Biology, 13 p.1775-1785
Journal articleCAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion
M. Schaber, A. Lindgren, K. Schindler, D. Bungard, P. Kaldis, et al.
(2002) Molecular and Cellular Biology, 22 p.57-68
Journal articleCAK-independent activation of CDK6 by a viral cyclin
P. Kaldis, P. M. Ojala, L. Tong, T. P. Mäkelä, M. J. Solomon
(2001) Molecular Biology of the Cell, 12 p.3987-3999
Journal articleDephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Cα and β2 isoforms
Aiyang Cheng, Philipp Kaldis, Mark J. Solomon
(2000) Journal of Biological Chemistry, 275 p.34744-34749
Journal articleKinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast
Deborah A. Enke, Philipp Kaldis, Mark J. Solomon
(2000) Journal of Biological Chemistry, 275 p.33267-33271
Journal articleThe effects of changing the site of activating phosphorylation in CDK2 from threonine to serine
P. Kaldis, A. Cheng, M. J. Solomon
(2000) Journal of Biological Chemistry, 275 p.32578-32584
Journal articleAnalysis of CAK activities from human cells
Philipp Kaldis, Mark J. Solomon
(2000) European Journal of Biochemistry, 267 p.4213-4221
Journal articleActivating phosphorylation of the Saccharomyces cerevisiae cyclin- dependent kinase, Cdc28p, precedes cyclin binding
Karen E. Ross, Philipp Kaldis, Mark J. Solomon
(2000) Molecular Biology of the Cell, 11 p.1597-1609
Journal articleTransforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity
Hikaru Nagahara, Sergei A. Ezhevsky, Adamina M. Vocero-Akbani, Philipp Kaldis, Mark J. Solomon, et al.
(1999) Proceedings of the National Academy of Sciences of the United States of America, 96 p.14961-14966
Journal articleDephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases
Aiyang Cheng, Karen E. Ross, Philipp Kaldis, Mark J. Solomon
(1999) Genes and Development, 13 p.2946-2957
Journal articleThe cdk-activating kinase (CAK) : From yeast to mammals
P. Kaldis
(1999) Cellular and Molecular Life Sciences, 55 p.284-296
Journal article reviewThe CDK-activating kinase (Cak1p) from budding yeast has an unusual ATP binding pocket
Deborah A. Enke, Philipp Kaldis, Jennifer K. Holmes, Mark J. Solomon
(1999) Journal of Biological Chemistry, 274 p.1949-1956
Journal articleActivating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p
Jonathan Kimmelman, Philipp Kaldis, Christoph J. Hengartner, Geoffrey M. Laff, Sang Seok Koh, et al.
(1999) Molecular and Cellular Biology, 19 p.4774-4787
Journal articleLocalization and regulation of the cdk-activating kinase (Cak1p) from budding yeast
P. Kaldis, Z. W. Pitluk, I. A. Bany, D. A. Enke, M. Wagner, et al.
(1998) Journal of Cell Science, 111 p.3585-3596
Journal articleHuman and yeast Cdk-activating kinases (CAKs) display distinct substrate specificities
Philipp Kaldis, Alicia A. Russo, Hubert S. Chou, Nikola P. Pavletich, Mark J. Solomon
(1998) Molecular Biology of the Cell, 9 p.2545-2560
Journal articleRegulation of CDKs by phosphorylation
M. J. Solomon, P. Kaldis
(1998) Results and Problems in Cell Differentiation, 22 p.79-109
Journal article reviewFunctions of creatine kinase isoenzymes in spermatozoa
Philipp Kaldis, Günter Kamp, Thomas Piendl, Theo Wallimann
(1997) Advances in Developmental Biology, 5 p.275-312
Journal articleThe Cdk-activating kinase (CAK) from budding yeast
Philipp Kaldis, Ann Sutton, Mark J. Solomon
(1996) Cell, 86 p.553-564
Journal articleIdentification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa
Philipp Kaldis, Martin Stolz, Markus Wyss, Else Zanolla, Barbara Rothen-Rutishauser, et al.
(1996) Journal of Cell Science, 109 p.2079-2088
Journal article‘Hot Spots’ of creatine kinase localization in brain : Cerebellum, hippocampus and choroid plexus
Philipp Kaldis, Wolfram Hemmer, Else Zanolla, David Holtzman, Theo Wallimann
(1996) Developmental Neuroscience, 18 p.542-554
Journal articleFunctional differences between dimeric and octameric mitochondrial creatine kinase
P. Kaldis, T. Wallimann
(1995) Biochemical Journal, 308 p.623-627
Journal articleIn vitro complex formation between the octamer of mitochondrial creatine kinase and porin
Dieter Brdiczka, Philipp Kaldis, Theo Wallimann
(1994) Journal of Biological Chemistry, 269 p.27640-27644
Journal articleThe N-terminal heptapeptide of mitochondrial creatine kinase is important for octamerization
Philipp Kaldis, Rolf Furter, Theo Wallimann
(1994) Biochemistry, 33 p.952-959
Journal articleExpression of active-octameric chicken cardiac mitochondrial creatine kinase in Escherichia coli
R. Furter, P. Kaldis, E. M. Furter-Graves, T. Schnyder, H. M. Eppenberger, et al.
(1992) Biochemical Journal, 288 p.771-775
Journal article