Lund University is celebrating 350 years.


Javascript is not activated in your browser. This website needs javascript activated to work properly.

The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model

  • Andreas Lindqvist
  • Mikael Ekelund
  • Eliana Garcia-Vaz
  • Marcus Ståhlman
  • Stefan Pierzynowski
  • Maria F. Gomez
  • Jens F Rehfeld
  • Leif Groop
  • Jan Hedenbro
  • Nils Wierup
  • Peter Spégel
Publishing year: 2017-03-01
Language: English
Publication/Series: PLoS ONE
Volume: 12
Issue: 3
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Background A growing body of literature on Roux-en-Y gastric bypass surgery (RYGB) has generated inconclusive results on the mechanism underlying the beneficial effects on weight loss and glycaemia, partially due to the problems of designing clinical studies with the appropriate controls. Moreover, RYGB is only performed in obese individuals, in whom metabolism is perturbed and not completely understood. Methods In an attempt to isolate the effects of RYGB and its effects on normal metabolism, we investigated the effect of RYGB in lean pigs, using sham-operated pair-fed pigs as controls. Two weeks post-surgery, pigs were subjected to an intravenous glucose tolerance test (IVGTT) and circulating metabolites, hormones and lipids measured. Bile acid composition was profiled after extraction from blood, faeces and the gallbladder. Results A similar weight development in both groups of pigs validated our experimental model. Despite similar changes in fasting insulin, RYGB-pigs had lower fasting glucose levels. During an IVGTT RYGB-pigs had higher insulin and lower glucose levels. VLDL and IDL were lower in RYGB- than in sham-pigs. RYGB-pigs had increased levels of most amino acids, including branched-chain amino acids, but these were more efficiently suppressed by glucose. Levels of bile acids in the gallbladder were higher, whereas plasma and faecal bile acid levels were lower in RYGB- than in sham-pigs. Conclusion In a lean model RYGB caused lower plasma lipid and bile acid levels, which were compensated for by increased plasma amino acids, suggesting a switch from lipid to protein metabolism during fasting in the immediate postoperative period.


  • Endocrinology and Diabetes


  • Neuroendocrine Cell Biology
  • Diabetes and Endocrinology
  • ISSN: 1932-6203
Peter Spegel
E-mail: peter [dot] spegel [at] chem [dot] lu [dot] se


Centre for Analysis and Synthesis


Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00