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Metabolite profiling of LADA challenges the view of a metabolically distinct subtype

  • Mahmoud Al-Majdoub
  • Arslan Ali
  • Petter Storm
  • Anders H. Rosengren
  • Leif Groop
  • Peter Spégel
Publishing year: 2017-04-01
Language: English
Pages: 806-814
Publication/Series: Diabetes
Volume: 66
Issue: 4
Document type: Journal article
Publisher: American Diabetes Association Inc.

Abstract english

Latent autoimmune diabetes in adults (LADA) usually refers to GAD65 autoantibodies (GADAb)-positive diabetes with onset after 35 years of age and no insulin treatment within the first 6 months after diagnosis. However, it is not always easy to distinguish LADA fromtype 1 or type 2 diabetes. In this study, we examined whether metabolite profiling could help to distinguish LADA (n = 50) from type 1 diabetes (n = 50) and type 2 diabetes (n = 50). Of 123 identified metabolites, 99 differed between the diabetes types. However, no unique metabolite profile could be identified for any of the types. Instead, the metabolome varied along a C-peptide-driven continuum from type 1 diabetes via LADA to type 2 diabetes. LADA was more similar to type 2 diabetes than to type 1 diabetes. In a principal component analysis, LADA patients overlapping with type 1 diabetes progressed faster to insulin therapy than those overlapping with type 2 diabetes. In conclusion, we could not find any unique metabolite profile distinguishing LADA from type 1 and type 2 diabetes. Rather, LADA was metabolically an intermediate of type 1 and type 2 diabetes, with those patients closer to the former showing a faster progression to insulin therapy than those closer to the latter.


  • Endocrinology and Diabetes


  • Molecular Metabolism
  • Diabetes and Endocrinology
  • Islet patophysiology
  • ISSN: 0012-1797
Peter Spegel
E-mail: peter [dot] spegel [at] chem [dot] lu [dot] se


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