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Glycogen metabolism in the glucose-sensing and supply-driven β-cell

  • Lotta E. Andersson
  • Lisa M. Nicholas
  • Karin Filipsson
  • Jiangming Sun
  • Anya Medina Benavente
  • Mahmoud Al-Majdoub
  • Malin Fex
  • Hindrik Mulder
  • Peter Spégel
Publishing year: 2016-12-01
Language: English
Pages: 4242-4251
Publication/Series: FEBS Letters
Volume: 590
Issue: 23
Document type: Journal article (letter)
Publisher: Wiley-Blackwell

Abstract english

Glycogen metabolism in β-cells may affect downstream metabolic pathways controlling insulin release. We examined glycogen metabolism in human islets and in the rodent-derived INS-1 832/13 β-cells and found them to express the same isoforms of key enzymes required for glycogen metabolism. Our findings indicate that glycogenesis is insulin-independent but influenced by extracellular glucose concentrations. Levels of glycogen synthase decrease with increasing glucose concentrations, paralleling accumulation of glycogen. We did not find cAMP-elicited glycogenolysis and insulin secretion to be causally related. In conclusion, our results reveal regulated glycogen metabolism in human islets and insulin-secreting cells. Whether glycogen metabolism affects insulin secretion under physiological conditions remains to be determined.


  • Cell and Molecular Biology
  • human islets
  • INS-1 832/13
  • insulin secretion


  • Molecular Metabolism
  • ISSN: 0014-5793
Peter Spegel
E-mail: peter [dot] spegel [at] chem [dot] lu [dot] se


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