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Peter Spégel

Principal investigator

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Metabolite profiling of obese individuals before and after a one year weight loss program

Author

  • N. Geidenstam
  • M. Al-Majdoub
  • M. Ekman
  • P. Spégel
  • M. Ridderstråle

Summary, in English

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â

Department/s

  • Diabetes - Clinical Obesity
  • Diabetes - Molecular Metabolism
  • Centre for Analysis and Synthesis
  • EXODIAB: Excellence of Diabetes Research in Sweden

Publishing year

2017-09-01

Language

English

Pages

1369-1378

Publication/Series

International Journal of Obesity

Volume

41

Issue

9

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Nutrition and Dietetics

Status

Published

Research group

  • Diabetes - Clinical Obesity
  • Diabetes - Molecular Metabolism

ISBN/ISSN/Other

  • ISSN: 0307-0565