Peter Spégel

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, et al.
(2021) Molecular Metabolism, 51
Journal article

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

Alba Garcia-Serrano, Adélaïde A Mohr, Juliette Philippe, Cecilia Skoug, Peter Spégel, et al.
(2021) Aging and Disease
Journal article

Non-targeted analysis strategy for the identification of phenolic compounds in complex technical lignin samples

Jens Prothmann, Kena Li, Christian Hulteberg, Peter Spégel, Margareta Sandahl, et al.
(2020) ChemSusChem, 13 p.4605-4612
Journal article

Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes

Alicia Gil-Ramírez, Oskar Rosmark, Peter Spégel, Karl Swärd, Gunilla Westergren-Thorsson, et al.
(2020) Scientific Reports, 10
Journal article

Metabolomics Analysis of Nutrient Metabolism in β-Cells

Peter Spégel, Hindrik Mulder
(2020) Journal of Molecular Biology, 432 p.1429-1445
Journal article review

Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Ruchi Jain, Türküler Özgümüş, Troels Mygind Jensen, Elsa du Plessis, Magdalena Keindl, et al.
(2020) Scientific Reports, 10
Journal article

Metabolite profiling paradoxically reveals favorable levels of lipids, markers of oxidative stress and unsaturated fatty acids in a diabetes susceptible group of Middle Eastern immigrants

Mahmoud Al-Majdoub, Peter Spégel, Louise Bennet
(2020) Acta Diabetologica, 57 p.597-603
Journal article

Metabolic Effects of Gastric Bypass Surgery : Is It All About Calories?

Katharina Herzog, Johan Berggren, Mahmoud Al Majdoub, Claudia Balderas Arroyo, Andreas Lindqvist, et al.
(2020) Diabetes, 69 p.2027-2035
Journal article

Alterations in levels of intermediate-chained acylcarnitines associate with weight-gain following reestablishment of euthyroidism in Graves’ disease

Mahmoud Al Majdoub, Mikael Lantz, Peter Spégel
(2019) Endocrine, 63 p.164-166
Journal article

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Jakob G Knudsen, Alexander Hamilton, Reshma Ramracheya, Andrei I Tarasov, Melissa Brereton, et al.
(2019) Cell Metabolism, 29 p.4-442
Journal article

Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles

Mahmoud Al-Majdoub, Katharina Herzog, Bledar Daka, Martin Magnusson, Lennart Råstam, et al.
(2018) Metabolites, 8
Journal article

Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial

N. Safai, T. Suvitaival, A. Ali, P. Spégel, M. Al-Majdoub, et al.
(2018) Diabetic Medicine, 35 p.944-953
Journal article

Screening of stationary phase selectivities for global lipid profiling by ultrahigh performance supercritical fluid chromatography

Said Al Hamimi, Margareta Sandahl, Marina Armeni, Charlotta Turner, Peter Spégel
(2018) Journal of Chromatography A, 1548 p.76-82
Journal article

Novel subgroups of adult-onset diabetes and their association with outcomes : A data-driven cluster analysis of six variables

Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, et al.
(2018) The Lancet Diabetes and Endocrinology, 6 p.361-369
Journal article

Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

Lotta E. Andersson, Liliya Shcherbina, Mahmoud Al-Majdoub, Neelanjan Vishnu, Claudia Balderas Arroyo, et al.
(2018) Diabetes, 67 p.372-384
Journal article

Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response

Jie Xu, Tommy Jönsson, Merichel Plaza, Åsa Håkansson, Martin Antonsson, et al.
(2018) Nutrition Journal, 17
Journal article

The pathogenetic role of β-cell mitochondria in type 2 diabetes

Malin Fex, Lisa M. Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V. Sharoyko, et al.
(2018) Journal of Endocrinology, 236 p.145-149
Journal article review

Identification of lignin oligomers in Kraft lignin using ultra-high-performance liquid chromatography/high-resolution multiple-stage tandem mass spectrometry (UHPLC/HRMSⁿ)

Jens Prothmann, Peter Spégel, Margareta Sandahl, Charlotta Turner
(2018) Analytical and Bioanalytical Chemistry, 410 p.7803-7814
Journal article

Ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for analysis of lignin-derived monomeric compounds in processed lignin samples

Jens Prothmann, Mingzhe Sun, Peter Spégel, Margareta Sandahl, Charlotta Turner
(2017) Analytical and Bioanalytical Chemistry, 409 p.7049-7061
Journal article

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Julie Adam, Reshma Ramracheya, Margarita V. Chibalina, Nicola Ternette, Alexander Hamilton, et al.
(2017) Cell Reports, 20 p.3135-3148
Journal article

Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels

Mahmoud Al-Majdoub, Mikael Lantz, Peter Spégel
(2017) Thyroid : official journal of the American Thyroid Association, 27 p.1109-1117
Journal article

Metabolite profiling of obese individuals before and after a one year weight loss program

N. Geidenstam, M. Al-Majdoub, M. Ekman, P. Spégel, M. Ridderstråle
(2017) International Journal of Obesity, 41 p.1369-1378
Journal article

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

Annika Axelsson, T Mahdi, H A Nenonen, Tania Singh, S Hänzelmann, et al.
(2017) Nature Communications, 8 p.15652-15652
Journal article

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

Laila R.B. Santos, Carole Muller, Arnaldo H. de Souza, Hilton K. Takahashi, Peter Spégel, et al.
(2017) Molecular Metabolism, 6 p.535-547
Journal article

Metabolite profiling of LADA challenges the view of a metabolically distinct subtype

Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop, et al.
(2017) Diabetes, 66 p.806-814
Journal article

Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets

Said Alhamimi, LOVISA HEYMAN, Merichel Plaza, Charlotta Turner, Karin Berger, et al.
(2017) Molecular Nutrition and Food Research, 61
Journal article

The impact of Roux-en-Y gastric bypass surgery on normal metabolism in a porcine model

Andreas Lindqvist, Mikael Ekelund, Eliana Garcia-Vaz, Marcus Ståhlman, Stefan Pierzynowski, et al.
(2017) PLoS ONE, 12
Journal article

Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals

M. Al-Majdoub, N. Geidenstam, A. Ali, M. Ridderstråle, P. Storm, et al.
(2017) Diabetes & Metabolism, 43 p.475-479
Journal article (letter)

Glycogen metabolism in the glucose-sensing and supply-driven β-cell

Lotta E. Andersson, Lisa M. Nicholas, Karin Filipsson, Jiangming Sun, Anya Medina Benavente, et al.
(2016) FEBS Letters, 590 p.4242-4251
Journal article (letter)

Discriminative prediction of A-To-I RNA editing events from DNA sequence

Jiangming Sun, Yang De Marinis, Peter Osmark, Pratibha Singh, Annika Bagge, et al.
(2016) PLoS ONE, 11
Journal article

Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance.

Nina Geidenstam, Anders Danielsson, Peter Spégel, Martin Ridderstråle
(2016) Diabetes Research and Clinical Practice, 113 p.187-197
Journal article

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Jelena Stamenkovic, Lotta Andersson, Alice E. Adriaenssens, Annika Bagge, Vladimir Sharoyko, et al.
(2015) Biochemical Journal, 468 p.49-63
Journal article

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.

Lotta Andersson, Berengere Valtat, Annika Bagge, Vladimir Sharoyko, David Nicholls, et al.
(2015) PLoS ONE, 10
Journal article

Unique and Shared Metabolic Regulation in Clonal β-cells and Primary Islets Derived from Rat Revealed by Metabolomics Analysis.

Peter Spégel, Lotta Andersson, Petter Storm, Vladimir Sharoyko, Isabel Göhring, et al.
(2015) Endocrinology, 156 p.1995-2005
Journal article

Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.

Nils Wierup, Andreas Lindqvist, Peter Spégel, Leif Groop, Jan Hedenbro, et al.
(2015) Obesity Surgery, 25 p.180-185
Journal article

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Hedvig Bennet, Alexander Balhuizen, Anya Medina Benavente, Marloes Dekker Nitert, Emilia Ottosson Laakso, et al.
(2015) Peptides, 71 p.113-120
Journal article

Deletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice.

Peter Spégel, Aakash Chawade, Søren Nielsen, Per Kjellbom, Michael Rützler
(2015) Physiological Reports, 3
Journal article

Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.

Nina Geidenstam, Peter Spégel, Hindrik Mulder, Karin Filipsson, Martin Ridderstråle, et al.
(2014) Obesity, 22 p.2388-2395
Journal article

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

Yunzhao Tang, Annika Axelsson, Peter Spégel, Lotta Andersson, Hindrik Mulder, et al.
(2014) Science Translational Medicine, 6 p.139-257
Journal article

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.

Vladimir Sharoyko, Mia Abels, Jiangming Sun, Lisa Nicholas, Ines Mollet, et al.
(2014) Human Molecular Genetics, 23 p.5733-5749
Journal article

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.

Isabel Göhring, Vladimir Sharoyko, Siri Malmgren, Lotta Andersson, Peter Spégel, et al.
(2014) Journal of Biological Chemistry, 289 p.3786-3798
Journal article

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Peter Spégel, Andreas Lindqvist, Monica Sandberg, Nils Wierup
(2014) Regulatory Peptides, 189 p.11-16
Journal article

Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.

Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Eliana Garcia Vaz, Stefan Pierzynowski, et al.
(2014) Diabetes, 63 p.1665-1671
Journal article

Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Anna Zetterqvist, Lisa Berglund, Fabiana Blanco, Eliana Garcia Vaz, Maria Wigren, et al.
(2013) PLoS ONE, 8
Journal article

Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

Peter Spégel, Vladimir Sharoyko, Isabel Göhring, Anders Danielsson, Siri Malmgren, et al.
(2013) Biochemical Journal, 450 p.595-605
Journal article

Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.

Siri Malmgren, Peter Spégel, Anders Danielsson, Cecilia Nagorny, Lotta Andersson, et al.
(2013) Journal of Biological Chemistry, 288 p.11973-11987
Journal article

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans

Andreas Lindqvist, Mikael Ekelund, Hindrik Mulder, Peter Spégel, Leif Groop, et al.
(2013) Journal of Clinical Endocrinology and Metabolism, 98 p.856-861
Journal article

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

Parveen Kumar, Vladimir Sharoyko, Peter Spégel, Urban Gullberg, Hindrik Mulder, et al.
(2013) PLoS ONE, 8
Journal article

Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).

Peter Spégel, Ella Ekholm, Tiinamaija Tuomi, Leif Groop, Hindrik Mulder, et al.
(2012) Diabetes
Journal article

Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design

Anders Danielsson, Thomas Moritz, Hindrik Mulder, Peter Spégel
(2012) Metabolomics, 8 p.50-63
Journal article

NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice.

Darbaz Awla, Anna Zetterqvist, Aree Abdulla, Cristina Camello, Lisa Berglund, et al.
(2012) Gastroenterology, 143 p.1352-1352
Journal article

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines

Peter Spégel, Siri Malmgren, Vladimir Sharoyko, Philip Newsholme, Thomas Köck, et al.
(2011) Biochemical Journal, 435 p.277-284
Journal article

Continuous full filling capillary electrochromatography-electrospraying chromatographic nanoparticles

David Malmstrom, Jakob Axen, Jonas Bergquist, Peter Viberg, Peter Spégel
(2011) Electrophoresis, 32 p.261-267
Journal article

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

Ulrika Krus, Olga Kotova, Peter Spégel, Elna Hallgard, Vladimir Sharoyko, et al.
(2010) Biochemical Journal, 429 p.205-213
Journal article

A distinct metabolic profile at birth identifies children developing type 1 diabetes before 20 years of age

Daria La Torre, Åke Lernmark, Peter Spégel, H. Elding Larsson, Sten Ivarsson, et al.
(2010) Diabetologia, 53 p.261-261
Conference paper: abstract

Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism

Peter Spégel, Anders Danielsson, Karl Bacos, Cecilia Nagorny, Thomas Moritz, et al.
(2010) Metabolomics, 6 p.56-66
Journal article

Development and optimization of a metabolomic method for analysis of adherent cell cultures

Anders Danielsson, Thomas Moritz, Hindrik Mulder, Peter Spégel
(2010) Analytical Biochemistry, 404 p.30-39
Journal article

A lipotoxicity model in the INS-1 832/13 beta cell line and the epigenetic alterations induced by it

Siri Malmgren, Vladimir Sharoyko, David Nicholls, Cecilia Nagorny, Peter Spégel, et al.
(2010) Diabetologia, 53 p.348-348
Conference paper: abstract

Oxidative phosphorylation-dependent insulin secretion in pancreatic beta cells: new insights by disrupting TFB1M

Thomas Köck, Peter Spégel, Vladimir Sharoyko, Charlotte Ling, Hindrik Mulder
(2010) Diabetologia, 53 p.491-491
Conference paper: abstract

Novel Vinylpyridine Based Cationic MIP Monoliths for Enantiomer Separation in CEC

Peter Spégel, Leif Schweitz, Lars I. Andersson, Staffan Nilsson
(2009) Chromatographia, 69 p.277-285
Journal article

Metabolite profiling of clonal (832/13) beta cells after glucose stimulation

Peter Spégel, A. Danielsson, Cecilia Nagorny, Hindrik Mulder
(2009) Diabetologia, 52 p.117-117
Conference paper: abstract

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Valeriya Lyssenko, Cecilia Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, et al.
(2009) Nature Genetics, 41 p.82-88
Journal article

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

Celine Fernandez, Ulrika Krus, Elna Hallgard, Peter Spégel, Cecilia Holm, et al.
(2008) Journal of Proteome Research, 7 p.400-411
Journal article

Continuous full filling capillary electrochromatography: Nanoparticle synthesis and evaluation

Peter Spégel, Peter Viberg, Jonas Carlstedt, Patrik Petersson, Magnus Jornten-Karlsson
(2007) Journal of Chromatography A, 1154 p.379-385
Journal article

Nanoparticle-based capillary electrochromatography

Peter Spégel
(2007)
Dissertation

Reversed phase continuous full filling CEC-ESI-MS

Peter Viberg, Peter Spégel, J. Nilsson, P. Petersson, M. Joernten-Karlsson, et al.
(2007) Chromatographia, 65 p.291-297
Journal article

Continuous full filling capillary electrochromatography: Chromatographic performance and reproducibility

Peter Viberg, Peter Spégel, Jonas Carlstedt, Magnus Jornten-Karlsson, Patrik Petersson
(2007) Journal of Chromatography A, 1154 p.386-389
Journal article

Nanoparticle-based continuous full filling capillary electrochromatography/electrospray ionization-mass spectrometry for separation of neutral compounds

Christian Nilsson, Peter Viberg, Peter Spégel, Magnus Jörnten-Karlsson, Patrik Petersson, et al.
(2006) Analytical Chemistry, 78 p.6088-6095
Journal article

Peter Spégel

Publications