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Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

  • Jason L. Vassy
  • Peter Shrader
  • Anna Jonsson
  • Caroline S. Fox
  • Valeriya Lyssenko
  • Bo Isomaa
  • Leif Groop
  • James B. Meigs
  • Paul Franks
Publishing year: 2011
Language: English
Pages: 76-79
Publication/Series: Diabetes Research and Clinical Practice
Volume: 93
Issue: 2
Document type: Journal article
Publisher: Elsevier

Abstract english

Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend) = 0.03). The trend was similar among Framingham Offspring but was not statistically significant (p = 0.07). The meta-analyzed p value for trend from the two studies was 0.005. Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.


  • Endocrinology and Diabetes
  • Type 2 diabetes mellitus
  • Genetic risk score
  • Family history


  • Diabetes and Endocrinology
  • Genetic and Molecular Epidemiology
  • ISSN: 1872-8227
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49



Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00