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The Association between Dietary Energy Density and Type 2 Diabetes in Europe: Results from the EPIC-InterAct Study

Author:
  • Saskia W. van den Berg
  • Daphne L. van der A
  • Annemieke M. W. Spijkerman
  • Geertruida J. van Woudenbergh
  • Mariken J. Tijhuis
  • Pilar Amiano
  • Eva Ardanaz
  • Joline W. J. Beulens
  • Heiner Boeing
  • Francoise Clavel-Chapelon
  • Francesca L. Crowe
  • Blandine de Lauzon-Guillain
  • Guy Fagherazzi
  • Paul Franks
  • Heinz Freisling
  • Carlos Gonzalez
  • Sara Grioni
  • Jytte Halkjaer
  • Jose Maria Huerta
  • Inge Huybrechts
  • Rudolf Kaaks
  • Kay Tee Khaw
  • Giovanna Masala
  • Peter Nilsson
  • Kim Overvad
  • Salvatore Panico
  • J. Ramon Quiros
  • Olov Rolandsson
  • Carlotta Sacerdote
  • Maria-Jose Sanchez
  • Matthias B. Schulze
  • Nadia Slimani
  • Ellen A. Struijk
  • Anne Tjonneland
  • Rosario Tumino
  • Stephen J. Sharp
  • Claudia Langenberg
  • Nita G. Forouhi
  • Edith J. M. Feskens
  • Elio Riboli
  • Nicholas J. Wareham
Publishing year: 2013
Language: English
Publication/Series: PLoS ONE
Volume: 8
Issue: 5
Document type: Journal article
Publisher: Public Library of Science

Abstract english

Background: Observational studies implicate higher dietary energy density (DED) as a potential risk factor for weight gain and obesity. It has been hypothesized that DED may also be associated with risk of type 2 diabetes (T2D), but limited evidence exists. Therefore, we investigated the association between DED and risk of T2D in a large prospective study with heterogeneity of dietary intake. Methodology/Principal Findings: A case-cohort study was nested within the European Prospective Investigation into Cancer (EPIC) study of 340,234 participants contributing 3.99 million person years of follow-up, identifying 12,403 incident diabetes cases and a random subcohort of 16,835 individuals from 8 European countries. DED was calculated as energy (kcal) from foods (except beverages) divided by the weight (gram) of foods estimated from dietary questionnaires. Prentice-weighted Cox proportional hazard regression models were fitted by country. Risk estimates were pooled by random effects meta-analysis and heterogeneity was evaluated. Estimated mean (sd) DED was 1.5 (0.3) kcal/g among cases and subcohort members, varying across countries (range 1.4-1.7 kcal/g). After adjustment for age, sex, smoking, physical activity, alcohol intake, energy intake from beverages and misreporting of dietary intake, no association was observed between DED and T2D (HR 1.02 (95% CI: 0.93-1.13), which was consistent across countries (l(2) = 2.9%). Conclusions/Significance: In this large European case-cohort study no association between DED of solid and semi-solid foods and risk of T2D was observed. However, despite the fact that there currently is no conclusive evidence for an association between DED and T2DM risk, choosing low energy dense foods should be promoted as they support current WHO recommendations to prevent chronic diseases.

Keywords

  • Other Clinical Medicine
  • Endocrinology and Diabetes

Other

Published
  • Genetic and Molecular Epidemiology
  • Internal Medicine
  • ISSN: 1932-6203
Paul Franks
E-mail: paul [dot] franks [at] med [dot] lu [dot] se

Principal investigator

Genetic and Molecular Epidemiology

+46 40 39 11 49

60-12-021

33

Lund University Diabetes Centre, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00